A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis

Molecular Cancer Therapeutics

Volumn 8, Issue 9, 2009, Pages 2586-2596

  Huesca, Mario ^a   Lock, Lisa S ^a   Khine, Aye Aye ^a,b   Viau, Stéphane ^a,c   Peralta, Robert ^a   Cukier, I Howard ^a   Jin, Hongnan ^a   Al Qawasmeh, Raed A ^a,d   Lee, Yoon ^a   Wright, Jim ^a   Young, Aiping ^a  

^a Lorus Therapeutics Inc   (Canada)

^b Novx Systems Inc   (Canada)

^c Trillium Therapeutics Inc   (Canada)

^d UNIVERSITY OF JORDAN   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; KRUPPEL LIKE FACTOR 4; ML 133; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BREAST ADENOCARCINOMA; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL LEVEL; CELL PROLIFERATION; CHELATION; COLON ADENOCARCINOMA; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INDUCTION; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MELANOMA; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN D1; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; HOMEOSTASIS; HT29 CELLS; HUMANS; IMIDAZOLES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; PHENANTHROLINES; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SP1 TRANSCRIPTION FACTOR; UP-REGULATION; ZINC;

EID: 70349492702     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-1104     Document Type: Article

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