Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects

American Journal of Medical Genetics, Part A

Volumn 149, Issue 10, 2009, Pages 2080-2087

  Brandalize, Ana Paula Carneiro ^a,b   Bandinelli, Eliane ^a   Dos Santos, Pollyanna Almeida ^a   Roisenberg, Israel ^a   Schüler Faccini, Lavínia ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Congenital heart disease; Down syndrome; Folic acid; Genetic polymorphisms; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DNA POLYMORPHISM; DOWN SYNDROME; FEMALE; FOLATE METABOLISM; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MTHFR GENE; PRIORITY JOURNAL; RISK FACTOR;

ADULT; CASE-CONTROL STUDIES; CHILD; DOWN SYNDROME; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEART DEFECTS, CONGENITAL; HUMANS; INHERITANCE PATTERNS; MATERNAL AGE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MOTHERS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; RISK FACTORS;

EID: 70349490081     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.32989     Document Type: Article

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