A perspective on testing of existing pharmaceutical excipients for genotoxic impurities

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 2, 2009, Pages 200-204

  Brusick, David J ^a  

^a NONE   (United States)

Author keywords

Ames test; Drug Excipients; Genotoxicity; Impurities; Risk

Indexed keywords

ACRYLAMIDE; AFLATOXIN; BENZENE; BENZO[A]PYRENE; BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; CAFFEIC ACID; CARCINOGEN; CHLOROCRESOL; CHLOROGENIC ACID; DRUG; EXCIPIENT; FLAVONOID; FORMALDEHYDE; FURFURAL; HYDRAZINE; ISOASCORBIC ACID; NITROSAMINE; SACCHARIN SODIUM; SAFROLE; SILICON DIOXIDE; SODIUM CHLORIDE; SUCROSE; TITANIUM DIOXIDE; VANILLIN;

AMES TEST; ARTICLE; CELL ASSAY; DRUG APPROVAL; DRUG IMPURITY; DRUG MARKETING; DRUG RESEARCH; FOOD AND DRUG ADMINISTRATION; FOOD CONTAMINATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; NONHUMAN; PATIENT CARE; PATIENT SAFETY; PRIORITY JOURNAL; PUBLIC HEALTH; RESEARCH SUBJECT; TOXICITY TESTING; UNITED STATES;

DNA, BACTERIAL; DRUG CONTAMINATION; EXCIPIENTS; FOOD CONTAMINATION; HUMANS; MUTAGENICITY TESTS; MUTAGENS; PHARMACEUTICAL PREPARATIONS; PUBLIC HEALTH; RISK ASSESSMENT; SALMONELLA TYPHIMURIUM;

EID: 70349488194     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.07.006     Document Type: Article

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