Final common pathway for tinnitus: Theoretical and clinical implications of neuroanatomical substrates

International Tinnitus Journal

Volumn 15, Issue 1, 2009, Pages 5-50

  Shulman, Abraham ^a,b   Goldstein, Barbara ^a,b   Strashun, Arnold M ^b  

^a Martha Entenmann Tinnitus Research Center   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Affect; Attention; Consciousness; Cross modal integration brain function; Final common pathway; Medial temporal lobe; Neuroanatomical substrates; Paradoxical auditory memory

Indexed keywords

FLUORODEOXYGLUCOSE; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

AMYGDALOID NUCLEUS; ATTENTION; AUDITORY CORTEX; AUDITORY MASKING; AUDITORY STIMULATION; AWARENESS; BASAL GANGLION; BRAIN ASYMMETRY; BRAIN FUNCTION; BRAIN PERFUSION; CEREBELLUM; CINGULATE GYRUS; CLINICAL FEATURE; CLINICAL MEDICINE; CONCEPTUAL FRAMEWORK; CONFERENCE PAPER; CONSCIOUSNESS; CONTRAST ENHANCEMENT; DISABILITY SEVERITY; DISEASE COURSE; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; EMOTION; FEAR; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEARING; HIPPOCAMPUS; HUMAN; IDIOPATHIC DISEASE; INSULA; LEARNING ALGORITHM; LIMBIC CORTEX; MEDIAL LEMNISCUS; MENTAL FUNCTION; MENTAL STRESS; MOLECULAR MECHANICS; NEUROCHEMISTRY; NEUROIMAGING; NEUROPATHOLOGY; NEUROSCIENCE; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL CORTEX; PARABRACHIAL NUCLEUS; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SENSORIMOTOR INTEGRATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOMATOSENSORY SYSTEM; TEMPORAL LOBE; THALAMOCORTICAL TRACT; THALAMUS; TINNITUS; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; WORKING MEMORY;

AFFECT; ALGORITHMS; AROUSAL; ATTENTION; AUDITORY PATHWAYS; AUDITORY PERCEPTION; AWARENESS; BRAIN; BRAIN MAPPING; CEREBRAL CORTEX; DIAGNOSTIC IMAGING; DOMINANCE, CEREBRAL; ELECTROENCEPHALOGRAPHY; HUMANS; MENTAL RECALL; NERVE NET; SENSORY GATING; SENSORY RECEPTOR CELLS; SIGNAL PROCESSING, COMPUTER-ASSISTED; TINNITUS;

EID: 70349486936     PISSN: 09465448     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (257)

1. Shulman A, Strashun A. SPECT of brain and tinnitus neurootological neurologic implications. Presented at the Triologic Society, New York City, January 1993.
2. Shulman A. The final common pathway for tinnitus - the medial temporal lobe system. Int Tinnitus J 1(2):115-126, 1995.
3. Shulman A, Strashun AM, et al. Neurospect cerebral blood flow studies in patients with a central type tinnitus. In Tinnitus. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam: Kugler Publications, 1991: 211-217.
4. Shulman A, Strashun AM, Afriyie M, et al. SPECT imaging of brain and tinnitus - neurotologic neurologic implications. Int Tinnitus J 1(1):13-29, 1995.
5. Shulman A. Speculations and Conclusions: In A. Shulman, J Tonndorf, JM Aran, et al. (eds), Tinnitus Diagnosis/Treatment. Philadelphia: Lea and Febiger, 1991:547.
6. Shulman A, Goldstein B. Tinnitus dyssynchrony-synchrony theory: A translational concept for diagnosis and treatment and a model for the clinical diagnosis of different clinical type(s) of tinnitus. Int Tinnitus J 12(2):101-114, 2006.
7. Shulman A. Subjective Clinical Types of Tinnitus. A System of Nomenclature and Classification. In H Feldmann (ed), Proceedings of the Third International Tinnitus Seminar, Munster, 1987. Karlsruhe: Harsch Verlag, 1987.
8. Shulman A, Aran JM, Tonndorf J, et al. Clinical Types of Tinnitus. In A Shulman, JM Aran, J Tonndorf, et al. (eds), Tinnitus Diagnosis/Treatment. Philadelphia: Lea & Febiger, 1991:323-341, 354-372.
9. Shulman A, Seitz M. Central tinnitus - diagnosis and treatment: Observations of simultaneous auditory brainstem responses with monaural stimulation in the tinnitus patient. Laryngoscope 91:2025-2035, 1981. (Pubitemid 12205819)
10. Shulman A. Medical-Audiologic Tinnitus Patient Protocol. In A Shulman et al. (eds), Tinnitus Diagnosis/Treatment. Philadelphia: Lea & Febiger, 1991:319-321.
11. Descartes R. Principles of Philosophy and Explanation of Emotion; Passions of the Soul. In Meditations on Philosophy. Paris: Abbe Picot Translation, 1644.
12. Descartes R. The Philosophical Writings of Descartes, 3 vols. Trans. J Cottingham, R Stoothoff, D Murdoch, vol.3, including Anthony Kenny. Cambridge, UK: Cambridge University Press, 1988.
13. Frick GS, Strashun A, Aronson F, et al. The scintigraphic appearance at pathophysiologic loci in central type tinnitus; an Tc99m - HMPAO study. J Nucl Med (Suppl) May: 210, 1993.
14. Shulman A, Strashun A. SPECT imaging of brain and tinnitus. Presented at the Fourth International Seminar Inner Ear Medicine and Surgery, Snowmass, CO, July 1994.
15. Shulman A, Strashun A. SPECT Imaging of Brain and Tinnitus. Case Reports. In V Heertum, A Tikofsky (eds), Cerebral SPECT Imaging. New York: Raven Press, 1994: 210-212.
16. Shulman A. Final common pathway tinnitus. Invitation and presentation, University of Würzburg, Germany, January 1995.
17. Shulman A. A final common pathway for tinnitus - the medial temporal lobe system. Presentation, Charles University, Prague, Czech Republic, January 2005.
18. Shulman A, Strashun AM. Descending auditory system/cerebellum/tinnitus. Int Tinnitus J 5(2):92-106, 1999.
19. Arnold W, Bartenstein P, Oestreicher E, et al. Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: A PET study with [18F]deoxyglucose. ORL J Otorhinolaryngol Relat Spec 58:195-199, 1996. (Pubitemid 26305888)
20. Mirz F, Pedersen CB, Ishizu K, et al. Positron emission tomography of cortical centers of tinnitus. Hear Res 134:133-144, 1999.
21. Lockwood AH, Salvi RJ, Coad ML, et al. The functional neuroanatomy of tinnitus. Evidence for limbic system links and neural plasticity. Neurology 50:114-120, 1998.
22. Shulman A, Strashun AM, Avitable MJ, et al. Ultra-high frequency acoustic stimulation and tinnitus control: A positron emission tomography study. Int Tinnitus J 10(2); 113-126, 2004. (Pubitemid 41015942)
23. Shulman A, Goldstein B. Quantitative electroencephalography: Preliminary report - tinnitus. Int Tinnitus J 8(2):77-86, 2002. (Pubitemid 36008803)
24. Shulman A, Avitable MJ, Goldstein B. Quantitative electroencephalography power analysis in subjective idiopathic tinnitus patients, an electrophysiological correlate: A clinical paradigm shift in the understanding of tinnitus. Int Tinnitus J 12(2):121-132, 2006. (Pubitemid 46032581)
25. de Ridder D. Tinnitus : From basic science via non-invasive magnetic stimulation to brain surgery. Presentation at the Twenty-Sixth Annual International Tinnitus Forum, September 20, 2008.
26. Weiler EWJ, Brill K, Tachiki KH. Electroencephalography correlates in tinnitus. Int Tinnitus J 6(1):21-24, 2000.
27. Weiler EWJ, Brill K, Tachiki KH. Quantitative electroencephalography and tinnitus: A case study. Int Tinnitus J 6(2):124-126, 2000. (Pubitemid 32115156)
28. Weiler EWJ, Brill K, Tachiki KH, Schneider D. Neurofeedback and quantitative electroencephalography. Int Tinnitus J 8(1):87-93, 2002.
29. Weisz N, Muller S, Schlee W, et al. The neural code of auditory phantom perception. J Neurosci 27(11):1479-1484, 2007. (Pubitemid 46255446)
30. Weisz N, Dohrmann K, Elbert T. The relevance of spontaneous activity for the coding of the tinnitus sensation. Prog Brain Res 166:61-70, 2007. (Pubitemid 47595305)
31. Weisz N, Muller S, Schlee W, et al. The neural code of auditory phantom perception. J Neurosci 7:1479-1484, 2007. (Pubitemid 46255446)
32. Ashton H, Reid K, Marsh R, et al. High frequency localized "hot spots" in temporal lobes of patients with intractable tinnitus: A quantitative electroencephalographic (QEEG) study. Neurosci Lett 426:23-28, 2007.
33. Levine RA, Benson RR, Talavage TM, et al. Functional magnetic resonance imaging and tinnitus: Preliminary results [abstract]. Assoc Res Otolaryngol 20:65, 1997.
34. Melcher JR, Sigalovsky IS, Guinan JJ Jr, Levine RA. Lateralized tinnitus studied with functional magnetic resonance imaging: Abnormal inferior colliculus activation. J Neurophysiol 83:1058-1072, 2000.
35. Mirz F, Gjedde A, Brahe C, et al. Functional brain imaging of tinnitus-like perception induced by aversive auditory stimuli. NeuroReport 11(3):633-637, 2000. (Pubitemid 30120489)
36. Eggermont JJ, Roberts LE. The neuroscience of tinnitus. Trends Neurosci 27(11):677-682, 2004.
37. Noreña AJ, Eggermont JJ. Changes in spontaneous neural activity immediately after an acoustic trauma: Implications for neural correlates for tinnitus. Hear Res 183:137-153, 2003.
38. Noreña AJ, Eggermont JJ. Enriched acoustic environment after noise trauma reduces hearing loss and prevents cortical map reorganization. J Neurosci 25:699-705, 2005.
39. Eggermont JJ. Correlated neural activity has the driving force for functional changes in auditory cortex. Hear Res 229(1-2):69-80, 2007.
40. Noreña A, Micheyl C, Chéry-Croze S, et al. Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus. Audiol Neurootol 7(6):358-369, 2002. (Pubitemid 36151410)
41. Shulman A. Tinnitus neural substrates. An addendum. Int Tinnitus J 11(1):1-3, 2005.
42. Schoenbaum G, et al. Preface: Linking affect to action. Ann N Y Acad Sci 1121:xi-xiii, 2007.
43. Shulman A, Goldstein B. Subjective idiopathic tinnitus. A review of clinical experience 1979-2005. Otorhinolaryngology 55:23-33, 2005.
44. Shulman A, Goldstein B, Strashun AM. Central nervous system neurodegeneration and tinnitus: A clinical experience: Part I. Diagnosis. Int Tinnitus J 13(2):118-131, 2007.
45. Shulman A, Goldstein B, Strashun AM. Central nervous system neurodegeneration and tinnitus: A clinical experience: Part II. Translational neurovascular theory of neurodegenerative CNS disease. Int Tinnitus J 14(1):43-52, 2008.
46. Shulman A, Strashun AM, Goldstein BA. GABA-A-benzodiazepine-chloride receptor-targeted therapy for tinnitus control: Preliminary report. Int Tinnitus J 8(1):30-36, 2002. (Pubitemid 34701025)
47. Daftary A, Shulman A, Strashun AM, et al. Benzodiazepine receptor distribution in severe disabling tinnitus. Int Tinnitus J 10(1):17-23, 2004. (Pubitemid 38937889)
48. Dobie R. Depression and tinnitus. Otolaryngol Clin North Am 36(2):383-388, 2003.
49. Folmer RL, Griest SE, Martin WH. Obsessive compulsiveness in a population of tinnitus patients. Int Tinnitus J 14(2):127-130, 2008.
50. Wayner DS. A Cognitive Therapy Weekend Workshop for Tinnitus: A Followup Report. In JA Vernon, GE Reich (eds), Proceedings of the Fifth International Tinnitus Seminar. Portland, OR: American Tinnitus Association, 1996:607-610.
51. Sweetow RW. The evolution of cognitive-behavioral therapy as an approach to tinnitus management. Int Tinnitus J 1(2):61-65, 1995.
52. Langguth B, Kleinjung T, et al. Tinnitus severity, depression, and the big five personality traits. Prog Brain Res 166:221-225, 2007. (Pubitemid 47588070)
53. John ER. From synchronous neuronal discharges to subjective awareness? Prog Brain Res 150:143-171, 2005.
54. John ER, Prichep L. The anesthetic cascade. A theory of how anesthesia suppresses consciousness. Anesthesiology 102:447-471, 2005.
55. Carpenter MB. Gross Anatomy of the Brain. In Core Text of Neuroanatomy, 2nd ed. Philadelphia: Lea & Febiger, 1973:22-24.
56. Carpenter MB. The Cerebral Cortex. In Core Text of Neuroanatomy, 2nd ed. Philadelphia: Lea & Febiger, 1973:348-399.
57. Roberts AC, Robbins TW, Weiskrantz L (eds). The Prefrontal Cortex - Executive and Cognitive Functions. Oxford: Oxford University Press, 1998:248.
58. Lee JH, Russ BE, Orr LE, Cohen Y. Prefrontal activity predicts monkey's decisions during an auditory category task. Front Integr Neurosci 2009; 3:16.doi10.33889/neuro.07.016.2009.
59. Luria AR. The Higher Cortical Functions in Man. New York: Basic Books.
60. Janeke B, Cheetam M, Baumgartner P. Virtual reality and the role of the prefrontal cortex in adults and children. Front Neurosci 2009; Doi:10.3389/neuro.01.006.2009.
61. Dolan RJ. Keynote address: Revaluing the orbital prefrontal cortex. Ann N Y Acad Sci 1121:1-9, 2007.
62. Goldman-Rakic PS. Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Knowledge. In F Plum, V Mountcastle (eds), Handbook of Physiology - The Nervous System: V. Bethesda, MD: American Physiological Society.
63. Goldman-Rakic PS, Porrino RR. The primate medio dorsal (MD) nucleus and its projections to the frontal lobe. J Comp Neurol 242:535-560, 1985.
64. Cavada C, et al. The anatomical connections of the macaque monkey orbitofrontal cortex: a review. Cereb Cortex 10(3):220-242, 2000. (Pubitemid 30159290)
65. Barabas H, Pandya DN. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol 286:353-375, 1989.
66. Barabas H. Specialized elements of orbitofrontal cortex in primates. Ann N Y Acad Sci 1121:10-32, 2007.
67. Ghashghaei HT, Hilgetag CC, Barabas H. Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage 34:905-923, 2007. (Pubitemid 46394469)
68. Gallagher M, Holland PC. The amygdala complex: Multiple roles in associative learning and attention. Proc Natl Acad Sci U S A 91:11771-11776.
69. Wang XL, et al. Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc Natl. Acad Sci U S A 101:1368-1373, 2004.
70. Zikopolous B, Barabas H. Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms. J Neurosci 26:7384-17361
71. Holstege G, Bandler R, Saper CB. The emotional motor system. Prog Brain Res 107:3-6, 1996.
72. Petrides M. The orbitofrontal cortex: Novelty, deviation from expectation, and memory. Ann N Y Acad Sci 1121: 33-53, 2007.
73. Milner B. Disorders of learning and memory after temporal lobe lesions in man. Clin Neurosurg 19:421-446, 1972.
74. Squire LR, Zola-Morgan S. The medial temporal lobe system. Science 253:1380-1386, 1991.
75. Meunier M, Bachevalier M, Mishkin M, Murray E. Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J Neurosc 13:5418-5432, 1990. (Pubitemid 24001024)
76. Damasio AR. Descartes' Error. New York. Putnam, 1994.
77. Dickinson A, Balleine B. Motivational control of goal directed action. Anim Learn Behav 22:1-18, 1994. (Pubitemid 24054214)
78. Schultz W, Trembley L, Hollerman JR. Reward processing in primate orbitofrontal cortex and basal ganglia. Cereb Cortex 10(3):272-283, 2000. (Pubitemid 30159294)
79. Cools R, Clark L, Robbins TW. Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance. J Neurosci 24(5):1129-1135, 2004; doi10:1523/JNEUROSCI.4312-03.2004. (Pubitemid 38177020)
80. Bechara A, Damasio H, et al. Dissociation of working memory from decision making within the human prefrontal cortex. J Neurosci 18:428-437, 1998. (Pubitemid 28046800)
81. Iverson SD, Mishkin M. Preservative interference in monkeys following selective lesions in the inferior prefrontal convexity. Exp Brain Res 11:376-386.
82. Baylis LL, Gaffan D. Amygdalectomy and ventromedial prefrontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward. Exp Brain Res 86:617-622, 1991.
83. Thorpe SJ, Rolls ET, Maddison S. The orbitofrontal cortex: Neuronal activity in the behaving monkey. Exp Brain Res 49:93-115, 1983. (Pubitemid 13180756)
84. Trembly L, Schultz W. Relative reward preference in primate orbitofrontal cortex. Nature 398:704-708, 1999. (Pubitemid 29197648)
85. Selmon LD, Goldman-Rakic PS. Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey. J Neurosc 5:776-794, 1985.
86. Haber SN, Lynd EK, et al. Topographic organization of the ventral striatal efferent projections in the rhesus monkey: An autoradiographic tracing study. J Comp Neurol 293:282-298, 1990.
87. Eblen F, Graybiel AM. Highly restricted origin of prefrontal cortical inputs to striatum in the macaque monkey. J Neurosci 15:5999-6013, 1995.
88. Goble TJ, Moller AR, Thompson LT. Acute high-intensity sound exposure alters responses of place cells in hippocampus. Hear Res 253(1-2):52-59, 2009.
89. Ramus SJ, Davis JB, et al. Interactions between the orbitofrontal cortex and the hippocampal memory storage system during the storage of long-term memory. Ann N Y Acad Sci 1121: 216-231, 2007.
90. Eichenbaum H. A cortical-hippocampal system for declarative memory. Nat Rev Neurosci 1:41-50, 2000.
91. Ramus SJ, Eichenbaum H. A Brain System for Declarative Memory. In J Pomerantz (ed), Topics in Integrative Neuroscience: From Cells to Cognition. Cambridge: Cambridge University Press, 2007.
92. Tulving E. What is episodic memory? Curr Direc Psychol Sci 2:67-70, 1993.
93. Graf P, Schachter D. Implicit and explicit memory for new associations in normal and amnesic subjects. J Exp Psychol Learn Mem Cogn 11:501-518, 1985.
94. Murray E, Izquierdo A. Orbitofrontal cortex and amygdala contributions to affect and action in primates. Ann N Y Acad Sci 1121:273-296, 2007.
95. Wikipedia, the free encyclopedia. April 10, 2009, at 21:11 (UTC).
96. Robertson EM, Tormos JM, et al. The role of the dorsolateral prefrontal cortex during sequence learning is specific for spatial information. Cereb Cortex 1(7):628-635, 2001.
97. Procyk E, Goldman-Rakic PS. Modulation of dorsolateral prefrontal delay activity during self-organized behavior. J Neurosc 26:11313-11323, 2006. (Pubitemid 44772161)
98. Pribam KH, Mishkin M, et al. Effects of delayed-response performance of lesions of dorsolateral and ventrolateral frontal medial cortex of baboons. J Comp Physiol Psychol 45:565-575, 1952.
99. Goel V, Vartanian O. Dissociating the roles of right ventral lateral and dorsal lateral prefrontal cortex in generation and maintenance of hypotheses in set shift problems. Cereb Cortex 15(8):1170-1177, 2005. (Pubitemid 41373610)
100. Carpenter MB. The Pons. In Core Text of Neuroanatomy, 3rd ed. Baltimore: Williams & Wilkins, 1985:141-143.
101. Gray H, Goss CM. Anatomy of the Human Body. Philadelphia: Lea & Febiger, 1973:828-829.
102. Clemente, CD. Gross Anatomy of Central Nervous System. In Anatomy of the Human Body, 13th Am. ed. Philadelphia: Lea & Febiger, 1985:957-1047.
103. Rolls ET. Memory systems in the brain. Annu Rev Psychol 51:599-630, 2000.
104. Muhlnickel W, Elbert T, et al. Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci U S A 95:10340-10343, 1998.
105. Lenhardt ML, Shulman A, Goldstein B. The role of the parabrachial nucleus in the natural history of tinnitus and its synchronous activity implications. Int Tinnitus J 13(2):87-89, 2007.
106. Merzenich MM, Brugge JF. Representation of the cochlear partition on the superior plane of the macaque monkey. Brain Res 50:275-296, 1973.
107. Merzenich MM, Colwell SA, Andersen RA. Auditory Forebrain Organization. Thalamocortical and Corticothalamic Connections in the Cat. In CN Woolsey (ed), Cortical Sensory Organization, vol 3. Multiple Auditory Areas. Clifton, NJ: Humana Press, 1982:43-57.
108. Merzenich MM, Recanzone G, et al. Cortical Representational Plasticity. In P Rakic, W Singer (eds), Neurobiology of Neocortex. New York: Wiley, 1988:41-68.
109. Christopher de Charms R, Merzenich MM. Primary cortical representation of sounds by coordination of action potential timing. Nature 381:610-614, 1996.
110. Papez JW. A proposed mechanism of emotion. Arch Neurol Psychiatry 38:725-743, 1937.
111. Squire LR, Lindenhaus E. The Biology of Memory. Stuttgart: Schattauer Verlag, 1990:643-664.
112. Jacobson L, Sapolsky R. The role of the hippocampus in feedback regulation of the hippothalamic-pituitary-adrenal cortex axis. Endocr Rev 12:118, 1991.
113. Lockwood AH, Salvi RJ, et al. The functional neuroanatomy of tinnitus: Evidence for limbic system links and neural plasticity. Neurology 50:114-120, 1998. (Pubitemid 28106029)
114. van Hoesen GW, Pandya DN, Butters N. Cortical afferents to the entorhinal cortex of the rhesus monkey. Science 175(4029):1471-1473, 1972.
115. Meunier M, Cirilli L, Bachevalier J. Responses to affective stimuli in monkeys with entorhinal or perirhinal cortex lesions. J Neurosci 26(29):7718-7722, 2006. (Pubitemid 44315191)
116. Egorov AV, Hamam E, Fransén BN, et al. Graded persistent activity in entorhinal cortex neurons. Nature 420:173-178, 2002.
117. van Marle HJF, Llinas R, Shulman A, et al. Magnetoencephalographic recordings from tinnitus patients during masking procedures. Presented at the Thirteenth International Meeting on Biomagnetism, Germany, 2002. Int Tinnitus J 12(2):121-132, 2006.
118. Jastreboff PJ, Hazell JW, et al. A neurophysiological approach to tinnitus: Clinical implications. Br J Audiol 27:7-17, 1993.
119. Smith CD, Lori NF, Coturo TE, et al. MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans. J Magn Reson Imaging 29:1248-1261, 2009.
120. Disbrow E, Litinas E, Recanzone GH, et al. Thalamocortical Connections of the Parietal Ventral Area (PV) and the Second Somatosensory Area (S2) in Macaque Monkeys. In Thalamus & Related Systems. Cambridge: Cambridge University Press, 2002:289-302.
121. Dehaene S, Changeux J-P. Neural Mechanisms for Access to Consciousness. In M Gazzaniga (ed), The Cognitive Neurosciences III. Cambridge, MA: MIT Press, 2004.
122. Carpenter MB. Gross Anatomy of the Brain. In Core Text of Neuroanatomy, 2nd ed. Philadelphia: Lea & Febiger, 1973: 47-50.
123. Middleton FA, Strick PL. The cerebellum: An overview. Trends Neurosci 21:367-368, 1998.
124. Thompson RF. Classical conditioning. Science 223:291-294, 1986.
125. Desmond JE, Fiez JA. Neuroimaging studies of cerebellum: Language, learning and memory. Trends Cogn Sci 2:355-362, 1995.
126. Schmahmann JD. Dysmetria of thought: Clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci 2:362-371, 1998.
127. Gilman S, Bloedel JR, Lechtenberg R. Disorders of the Cerebellum. The Responses of Cerebellar Neurons. Philadelphia: F. A. Davis Co., 1981:95-99.
128. Pastor MA, Vidaurre C, Fernández-Seara MA, et al. Frequency-specific coupling in the cortico-cerebellar auditory system. J Neurophysiol 100(4):1699-1705, 2008.
129. Ross B, Herdman AT, Pantev C. Stimulus induced desynchronization of human auditory 40-Hz steady-state responses. J Neurophysiol 94:4082-4093, 2005. (Pubitemid 41691770)
130. Middleton FA, Strick PL. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 266:458-461, 1994.
131. Ribary U, Ioannides AA, Singh KD, et al. Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. Proc Natl Acad Sci U S A 88:11037-11041, 1991. (Pubitemid 21915974)
132. Pastor MA, Artieda J, Arbizu J, et al. Activation of human cerebral and cerebellar cortex by auditory stimulation at 40 Hz. J Neurosci 22:10501-10506, 2002. (Pubitemid 35416887)
133. Schmahmann JD, Doyon J, McDonald D, et al. Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space. Neuroimage 10:233-260, 1999. (Pubitemid 29444762)
134. Pastor MA, Artieda J, Arbizu J, et al. Human cerebral activation during steady-state visual-evoked responses. J Neurosci 23:11621-11627, 2003. (Pubitemid 38021289)
135. Schmahmann JD, Pandya DN. Projections to the basis pontis from the superior temporal sulcus and superior temporal region in the rhesus monkey. J Comp Neurol 308:224-248, 1991.
136. Clower DM, West RA, Lynch JC, Strick PL. The inferior parietal lobule is the target of output from the superior colliculus, hippocampus, and cerebellum. J Neurosci 21(16):6283-6291, 2001.
137. Brodal P. The pontocerebellar projection in the rhesus monkey: An experimental study with retrograde axonal transport of horseradish peroxidase. Neuroscience 4: 193-208, 1979. (Pubitemid 9100260)
138. Smotherman M, Kobayasi K, et al. A mechanism for vocal-respiratory coupling in the mammalian parabranchial nucleus. J Neurosci 26(18):4860-44869, 2006. (Pubitemid 44315327)
139. Wallhauser-Franke E. Salicylate evokes c-fos expressionism the brain stem: Implications for tinnitus. Neeuroreport 8:723-728, 1997.
140. Mahlke C, Wallhäusser-Franke E. Evidence for tinnitus-related plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry. Hear Res 195:17-34, 2004. (Pubitemid 39179879)
141. Craig AD. How do you feel? Interoception. The sense of the physiological condition of the body. Nat Rev Neurosci 3:655-666, 2002.
142. Carpenter MB. Gross Anatomy of the Brain. In Core Text of Neuroanatomy, 2nd ed. Philadelphia: Lea & Febiger, 1973:25-26.
143. Kolb B, Whishaw IQ. Fundamentals of Human Neuropsychology, 5th ed. New York: Worth, 2003.
144. Stein BE, Meredith A. The Merging of the Senses. Cambridge, MA: MIT Press, 1993.
145. Shulman A. Final common pathway for tinnitus - update: 2008. Anatomic substrates. Presented at the Thirty-fifth International Neuroequilibriometric Society Congress, Bad Kissingen, Germany, April 10-13, 2008.
146. Mesulam MM, Mufson EJ. The Insula of Reil in Man and Monkey. Architectonics, Connectivity, and Function. In A Peters, EG Jones (eds), Cerebral Cortex. New York: Plenum, 1985:179-226.
147. Cole LJ, Farrell MJ, Duff EP, et al. Pain sensitivity and fMRI pain-related brain activity in Alzheimer's disease. Brain 129(11):2957-2965, 2006. (Pubitemid 44684516)
148. Peyron R, Frot M, Garcia-Larrea L, et al. Role of operculoinsular cortices in human pain processing: Converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials. Neuroimage 17(3):1336-1346, 2002. (Pubitemid 35333854)
149. Lenhardt ML, Shulman A, Goldstein BA. The role of the insula cortex in the final common pathway for tinnitus: Experience using ultra-high-frequency therapy. Int Tinnitus J 14(2):13-17, 2008. (Pubitemid 351898441)
150. Paulus MP, Stein MB. An insular view of anxiety. Biol Psychiatry 60:383-387, 2006.
151. Paulus MP. Decision-making dysfunctions in psychiatry - altered homeostatic processing? Science 318:602-606, 2007.
152. Craig AD. Human feelings: Why are some more aware than others? Trends Cogn Sci 8:239-241, 2004.
153. Carpenter MB. Gross Anatomy of the Brain. In Core Text of Neuroanatomy, 2nd ed. Philadelphia: Lea & Febiger, 1973:34-35.
154. Voorn P, Vanderschurreen LJM, et al. Putting a spin on the dorsal ventral divide of the striatum. Trends Neurosci 27(8):468-474, 2004. (Pubitemid 38951039)
155. Nolte J. The Human Brain: An Introduction to Its Functional Anatomy, 5th ed. St. Louis: Mosby, Inc., 2002:464-484.
156. Noback CR, Strominger NL, et al. The Human Nervous System, 6th ed. New York: Humana Press, 2005:421.
157. Gray H, Goss CM. Central Nervous System. In Anatomy of the Human Body. Philadelphia: Lea & Febiger, 1973:67.
158. O'Doherty J, Dayan P, Schultz J, et al. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 304:452-454, 2004. (Pubitemid 38495943)
159. McCullough LD, Sokolowski JD, Salamone JD. A neurochemical and behavioral investigation of the involvement of nucleus accumbens dopamine in instrumental avoidance. Neuroscience 52:919-925, 1993.
160. Koob GF. Neurobiology of addiction. Toward the development of new therapies and brain stem raphe nuclei. Ann N Y Acad Sci 909:170-185, 2000.
161. Brown P, Molliver ME. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: Relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J Neurosci 20:1952-1963, 2000.
162. O'Donnell P, Lavin A, Enquist LW, et al. Interconnected parallel circuits between rat nucleus accumbens and thalamus revealed by retrograde transynaptic transport of Pseudorabies virus. J Neurosci 17:2143-2167, 1997. (Pubitemid 27106770)
163. Mühlau M, Rauschecker JP, Oestreicher E, et al. Structural brain changes in tinnitus. Cereb Cortex 16(9):1283-1288, 2006. (Pubitemid 44289101)
164. Carpenter MB. Gross Anatomy of the Brain. In Core Text of Neuroanatomy, 3rd ed. Baltimore: Williams & Wilkins, 1985:44-46.
165. Purpura DP. Operations and Processes in the Thalamic and Synaptically Related Neural Systems. In FO Schmitt (ed), The Neurosciences, Second Study Program. New York: Rockefeller University Press, 1970:458-470.
166. Gray H, Goss CM. Anatomy of the Human Body. Philadelphia: Lea & Febiger, 1973:828-829.
167. Brugge JF. An Overview of Central Auditory Processing. In RR Fay, AN Popper (eds), The Mammalian Auditory Pathway: Neurophysiology. Springer Handbook of Auditory Research. Berlin: Springer-Verlag, 1992:1-33.
168. Pandya DN, Yeterian EH. Architecture and Connections of Cortical Association Areas. In A Peters, EG Jones (eds), Cerebral Cortex, vol.4: Association and Auditory Cortices. New York: Plenum Press, 1985:3-61.
169. Aitkin LM. The Auditory Midbrain: Structure and Function in the Central Auditory Pathway. Clifton, NJ: Humana Press, 1986.
170. Brugge JF. Personal correspondence, March 5, 1991.
171. Moller AR. Sensory Systems: Anatomy and Physiology. Amsterdam: Academic Press, 2003.
172. Shulman A, Goldstein B. Subjective Idiopathic tinnitus and palliative care: A plan for diagnosis and treatment. Otolaryngol Clin North Am 42:15-37, 2009.
173. Somjen G. Sensory Coding in the Mammalian Nervous System. New York: Appleton-Century-Crofts, 1972.
174. Haralanov S, Claussen C-F, et al. Computerized ultrasonographic craniocorpography and abnormal psychomotor activity in psychiatric patients. Int Tinnitus J 8(2):72-76, 2002. (Pubitemid 36008802)
175. Kandel E, Schwartz JA. Brain and Behavior. In Principles of Neural Science, 2nd ed. Amsterdam: Elsevier, 1985:3-11.
176. James W. The Principles of Psychology. Cambridge, MA: Harvard University Press, 1981 (originally published in 1890).
177. Baars BJ. A Cognitive Theory of Consciousness. Cambridge: Cambridge University Press, 1988.
178. Baars BJ, Franklin S. How conscious experience and working memory interact. Trends Cogn Sci 7(4), 2003. (Pubitemid 36411824)
179. Hughes JR, John ER. Conventional and quantitative electroencephalography in psychiatry. J Neuropsychiatr Clin Neurosci 11:190-208, 1999.
180. John ER, Prichep L, et al. Neurometrics. Science 293:162-169, 1988.
181. Duffy FH, Jones K, et al. Spectral coherence in normal adults. Clin EEG 26:30-46, 1995.
182. Koenig T, Prichep L, et al. Milisecond by millisecond, year by year: Normative EEG microstates and developmental stages. Neuroimage 16:41-48, 2002. (Pubitemid 34852471)
183. Buzsaki G. Theta oscillations in the hippocampus. Neuron 33:325-340, 2002.
184. Canolty RT, Edwards E, Dalai SS, et al. High gamma power is phase locked to theta oscillations in human neocortex. Science 313:5794-5795, 2006. (Pubitemid 44414034)
185. Crick F. The Astonishing Hypothesis: The Scientific Search for the Soul. Bel Air, CA: Scribner, 1994.
186. Crick F, Koch C. A framework for consciousness. Nat Neurosci 6:119-126, 2003.
187. Aladjalova NA. Infra-slow rhythmic oscillations of the steady potential of the cerebral cortex. Nature 4567:957-959, 1957.
188. Aladjalova NA. Slow Electrical Processes in the Brain. Moscow: Academy of Sciences USA, 1962.
189. Ball GJ, Gloor P, Schaul N. The cortical electromicrophysiology of pathological delta waves in the electroencephalogram of cats. Electroencephalogr Clin Neurophysiol 43:346-361, 1977. (Pubitemid 8185218)
190. Steriade M, Gloor P, Llinas RR, et al. Basic mechanisms of cerebral rhythmic activities. EEG Clin Neurophysiol 76:481-508, 1990.
191. McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Prog Neurobiol 39:337-338, 1992.
192. McCormick DA. Cortical and subcortical generators of normal and abnormal rhythmicity. Int Rev Neurobiol 49:99-113, 2002.
193. Llinas R, Urbano FJ, et al. Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci 28(6):325-333, 2005. (Pubitemid 40775778)
194. Llinas R. The intrinsic properties of mammalian neurons: Insights into central nervous system function. Science 242:1654-1664, 1988. (Pubitemid 19022170)
195. LeDoux JE. Information Flow from Sensation to Emotion Plasticity in the Neural Computation of Stimulus Value. In M Gabriel, J Moore (eds), Learning and Computational Neuroscience: Foundations of Adaptive Networks. Cambridge, MA: Bradford Books, MIT Press, 1990:3-52.
196. LeDoux JE, Cicchetti P, Xagoraris A, Romanski LM. The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. J Neurosci 10(4):1062-1069, 1990.
197. Webster's New World Dictionary, 3rd college ed. Springfield, MA: Merriam-Webster, 1988:88.
198. James W. The Principles of Psychology. New York: Holt, 1890:403-404.
199. Posner MI, Petersen SE. The attention system of the human brain [review]. Annu Rev Neurosci 13:25-42, 1990. (Pubitemid 20100639)
200. Posner MI. Visual Attention. In JF Martha, G. Ratcliff (eds), The Neuropsychology of High Level Vision: Collected Tutorial Essays. Hillsdale, NJ: Lawrence Erlbaum Associates, 1994:217-239.
201. Tsotos, et al. Modeling visual attention via selective tuning. Artif Intell 78:507, 1995.
202. Treisman A, Paterson R. Emergent features, attention and object perception. J Exp Psychol Hum Percept Perform 10:12-31, 1984.
203. La Berge D. Attentional Processing: The Brain's Art of Mindfulness. Cambridge, MA: Harvard University Press, 1995.
204. Perry RJ, Hodges JR. Attention and execution deficits in Alzheimer's disease: A critical review. Brain 122:383-404, 1999.
205. Corbett M, Shulman G. Control of goal directed and stimulus driven attention in brain. Nat Rev Neurosci 3: 201-215, 2002.
206. Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci U S A 103(26):10046-10051, 2006. (Pubitemid 43993620)
207. Otazu GH, Zador AM, et al. Engaging in an auditory task suppresses responses in the auditory cortex. Nat Neurosci 12(5):646-654, 2009.
208. White LK, Helfenstein, Fox NA, et al. Role of attention in the regulation of fear and anxiety. Dev Neurosci 31:309-317, 2009; DOI: 10.1159/000216542.
209. Taylor JG, Fragopanagos N. Modeling the interaction of attention and emotion. Neurol Networks 3(31):1663-1668, 2005.
210. Poghosyan V, Ioannides AA. Attention modulates earliest responses in the primary auditory and visual cortices. Neuron 58(5):802-813, 2008. (Pubitemid 351778468)
211. Dornhoffer J, Danner C, Mennemeier M, et al. Arousal and attention deficits in patients with tinnitus. Int Tinnitus J 12(1):9-16, 2006. (Pubitemid 44784025)
212. Shihui H, Yi J, et al. The role of human parietal cortex in attention networks. Brain 127(3), 650-659, 2004. (Pubitemid 38295478)
213. Fritz J, Shamma S, Klein D, et al. Rapid task-related plasticity of spectrotemporal receptive fields in the primary auditory cortex. Nat Neurosci 6:1216-1223, 2003. (Pubitemid 37346043)
214. Sumbre G, Muto A, et al. Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval. Nature 456:102-106, 2008.
215. Quintana J, Fuster JM. From perception to action: Temporal integrative functions of prefrontal and parietal neurons. Cereb Cortex 9:213-221, 1999. (Pubitemid 29231226)
216. Komura Y, et al. Retrospective and prospective coding for predicted reward in the sensory thalamus. Nature 412:546-549, 2001.
217. Miller EK, Desimone R. Parallel neuronal mechanisms for short-term memory. Science 263:520-522, 1994. (Pubitemid 24082751)
218. Shulman A. Stress model for tinnitus. Presentation at the International Tinnitus Study Group, Washington, DC, September 1992.
219. Shulman A. Stress Model for Tinnitus. In Proceedings of the Twenty-first Scientific Meeting of the NES, vol 22, 1995.
220. Shulman A. Stress model for tinnitus. Neurotol Newslett 3:53, 1998.
221. Elzinga BM, Bremner JD. Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? J Affect Disord 70(1):1-17, 2002.
222. Miller MM, McEwen BS. Establishing an agenda for translational research for PTSD. Ann N Y Acad Sci 1071: 294-312, 2006.
223. Small DM. Cross modal integration - insights from the chemical senses. Trends Neurosci 27(3):120-123, 2004.
224. Calvert GA. Crossmodal processing in the human brain: Insights from functional neuroimaging studies. Cereb Cortex 11:1110-1123, 2001. (Pubitemid 33108238)
225. Gottfried JA, Dolan RJ. The nose smells what the eyes see: Crossmodal visual facilitation of human olfactory perception. Neuron 3:375-396, 2003.
226. Vernon JA. Common Errors in the Use of Masking for Relief of Tinnitus. In A Shulman, et al. (eds), Tinnitus Diagnosis/Treatment. Philadelphia: Lea & Febiger, 1991:5-66.
227. Cameron KA, Yashar CL, Fried I, et al. Human hippocampal neurons predict how well word pairs will be remembered. Trends Cogn Sci 6(5):217-223, 2002.
228. Brewer JB, Moghekar A. Imaging the medial temporal lobe: Exploring new dimensions. Trends Cogn Sci 6(5):217-223, 2002. (Pubitemid 34451014)
229. de Ridder D, Verstraeten E, van der Kelen K, et al. Somatosensory cortex stimulation for deafferentation pain. Acta Neurochir Suppl 97(2):67-74, 2007.
230. de Ridder D, de Mulder G, Verstraeten E, et al. Auditory cortex stimulation for tinnitus. Acta Neurochir Suppl 97(2):451-462, 2007.
231. de Ridder D, de Mulder G, Verstraeten E, et al. Primary and secondary auditory cortex stimulation for intractable tinnitus. ORL J Otorhinolaryngol Relat Spec 68(1):48-54, 2006. (Pubitemid 43339687)
232. van der Loo E, Congedo M, van de Heyning P, de Ridder D. Electrical stimulation of the auditory cortex as a treatment for tinnitus. Frontiers in Human Neuroscience. Conference Abstract, Tenth International Conference on Cognitive Neuroscience, 2008; doi:10.3389/conf.neuro.09.2009.01.315.
233. Petrides M. Lateral prefrontal cortex: Architectonic and functional organization. Phil Trans R Soc B 360:781-795, 2005. (Pubitemid 40885665)
234. Butler CM. Habituation of responses to novel stimuli in monkeys with selective frontal lesions. Science 144:313-315, 1964.
235. John RE, et al. Normative Data Banks and Neurometrics: Basic Concepts. In EEG Handbook. New York: Elsevier, 1987:449-495.
236. Pascual-Marqui RD, Michel CM, Lehmann D. Low resolution electromagnetic tomography: A new method for localizing electrical activity in the brain. Int J Psychophysiol 18:49-65, 1994. (Pubitemid 24344515)
237. Bosch-Bayard J, Valdes-Sosa P, et al. 3D statistical parametric mapping of EEG source spectra by means of variable resolution electromagnetic tomography. Clin Electroencephalogr 32(2):47-61, 2001. (Pubitemid 32463602)
238. Eggermont JJ. Pathophysiology of tinnitus. Prog Brain Res 166:19-35, 2007.
239. Weisz N, Moratti S, Meinzer M, et al. Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography. PLOS Med 2 e153.
240. Weisz N, Hartmann T, Norena A, et al. High frequency tinnitus without hearing loss does not mean absence of deafferentation. Hear Res 222:108-114, 2006. (Pubitemid 44708559)
241. Llinas R, Ribary U, Jeanmonod D, et al. Thalamocortical dysrhythmia. A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci U S A 96:15222-15227, 1999.
242. Nuñez PL, Wingeier BM, Silberstein RB. Spatial temporal structures of human alpha rhythms: Theory, microcurrent sources, multiscale measurements, and global binding of local networks. Hum Brain Map 13:125-164.
243. Bertora GO, Bergmann JM. A new tinnitus model investigated through brain electric tomography - LORETA. Proceedings of the Thirty-fifth Congress of the NES, 2008. http:www.neurotology.org/archives/438.
244. Christiansen SA. Handbook of Emotion and Memory: Current Research and Theory. Hillsdale, NJ: Erlbaum, 1992.
245. Popescu AT, Popa D, Pare D. Coherent gamma oscillations couple the amygdala and striatum during learning. Nat Neurosci 12(6):801-807, 2009.
246. Zachle T, Freund I, et al. Inter- and intraindividual covariations of hemodynamic and oscillatory gamma responses in the human cortex. Front Hum Neurosci 3:8, 2009; doi:10.3389/neuro.09.008.2009.
247. Kayser C, Logothetis NK. Directed interactions between auditory and superior temporal cortices and their role in sensory integration. Front Integr Neurosci 3:7, 2009. doi.10.3389/neuro.07.007.2009.
248. Gibson EJ. Perceptual learning. Annu Rev Psychol 14:29-56, 1963.
249. Law Chi-TAT, Gold JI. Reinforcement learning can account for associative and perceptive learning on a visual-decision task. Nat Neurosci 12(5):655-663, 2009.
250. Langguth B, Hajak G, Kleinjung T, et al. Repetitive transcranial magnetic stimulation and chronic tinnitus. Acta Otolaryngol Suppl 556:102-105, 2006. (Pubitemid 44777338)
251. Kleinjung T, Steffens T, Londero A, Langguth B. Transcranial magnetic stimulation (TMS) for the treatment of chronic tinnitus: Clinical effects. Prog Brain Res 166:359-367, 2007.
252. de Ridder D, van der Loo E, van der Kelen K, et al. Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially? Int J Med Sci 4:242-246, 2007.
253. Kelley AE. Ventral striatal control of appetitive motivation: Role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 27(8):765-776, 2004.
254. Baxter MG, Murray EA. The amygdala and reward. Nat Rev Neurosci 3:563-573, 2002.
255. Ferreira TL, Shammah-Lagnado SJ, Oliveira MG, et al. The indirect amygdala-dorsal striatum pathway mediates conditioned freezing: Insights on emotional memory networks. Neuroscience 153(1):84-94, 2008.
256. Buckley MJ, Mansouri FA, et al. Dissociable components of rule-guided behavior depend on distinct medial and prefrontal science. Science 3:52-58, 2009.
257. Shulman A. Tinnitology, tinnitogenesis, nuclear medicine, and tinnitus patients. Int Tinnitus J 4(2):102-108, 1998. (Pubitemid 29447767)