Pulmonary vascular response to air-breathing exercise in humans following an 8-h exposure to hypoxia

Respiratory Physiology and Neurobiology

Volumn 169, Issue 1, 2009, Pages 11-15

  Herigstad, Mari ^a   Robbins, Peter A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Exercise; Hypoxia; Pulmonary circulation

Indexed keywords

ADULT; ARTERY DILATATION; ARTICLE; BLOOD PRESSURE; BREATHING EXERCISE; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; EUOXIA; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG FUNCTION; LUNG VASOCONSTRICTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REST; SYSTOLE; TRICUSPID VALVE; VASODILATATION;

ADULT; ALTITUDE; ANALYSIS OF VARIANCE; ANOXIA; BLOOD PRESSURE; BREATHING EXERCISES; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HEART RATE; HUMANS; MALE; PULMONARY CIRCULATION; REST; TIDAL VOLUME; TIME FACTORS; YOUNG ADULT;

EID: 70349451558     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2009.08.002     Document Type: Article

References (28)

1. Allemann Y., Sartori C., Lepori M., Pierre S., Melot C., Naeije R., Scherrer U., and Maggiorini M. Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H2013-2016
2. Balanos G.M., Dorrington K.L., and Robbins P.A. Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1. J. Appl. Physiol. 92 (2002) 2501-2507
3. Balanos G.M., Talbot N.P., Dorrington K.L., and Robbins P.A. Human pulmonary vascular response to 4 h of hypercapnia and hypocapnia measured using Doppler echocardiography. J. Appl. Physiol. 94 (2003) 1543-1551
4. Banchero N., Sime F., Peñaloza D., Cruz J., Gamboa R., and Marticorena E. Pulmonary pressure, cardiac output, and arterial oxygen saturation during exercise at high altitude and at sea level. Circ. Res. 33 (1966) 249-262
5. Barratt-Boyes B.G., and Wood E.H. Hemodynamic response of healthy subjects to exercise in the supine position while breathing oxygen. J. Appl. Physiol. 11 1 (1957) 129-135
6. Brusselmans K., Compernolle V., Tjwa M., Wiesener M.S., Maxwell P.H., Collen D., and Carmeliet P. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J. Clin. Invest. 111 (2003) 1519-1527
7. Bushuev V.I., Miasnikova G.Y., Sergueeva A.I., Polyakova L.A., Okhotin D., Gaskin P.R., Debebe Z., Nekhai S., Castro O.L., Prchal J.T., and Gordeuk V.R. Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia. Haematologica 91 (2006) 744-749
8. Currie P.J., Seward J.B., Chan K.L., Fyfe D.A., Hagler D.J., Mair D.D., Reeder G.S., Nishimura R.A., and Tajik A.J. Continuous wave Doppler determination of right ventricular pressure: a simultaneous Doppler-catheterization study in 127 patients. J. Am. Coll. Cardiol. 6 (1985) 750-756
9. Dexter L., Whittenberger J.L., Haynes F.W., Goodale W.T., Gorlin R., and Sawyer C.G. Effect of exercise on circulatory dynamics of normal individuals. J. Appl. Physiol. 3 (1951) 439-453
10. Dorrington K.L., Clar C., Young J.D., Jonas M., Tansley J.G., and Robbins P.A. Time course of the human pulmonary vascular response to 8 hours of isocapnic hypoxia. Am. J. Physiol. 273 (1997) H1126-1134
11. Eldridge M.W., Podolsky A., Richardson R.S., Johnson D.H., Knight D.R., Johnson E.C., Hopkins S.R., Michimata H., Grassi B., Feiner J., Kurdak S.S., Bickler P.E., Wagner P.D., and Severinghaus J.W. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J. Appl. Physiol. 81 (1996) 911-921
12. Groves B.M., Reeves J.T., Sutton J.R., Wagner P.D., Cymerman A., Malconian M.K., Rock P.B., Young P.M., and Houston C.S. Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J. Appl. Physiol. 63 (1987) 521-530
13. Grunig E., Mereles D., Hildebrandt W., Swenson E.R., Kubler W., Kuecherer H., and Bartsch P. Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J. Am. Coll. Cardiol. 35 (2000) 980-987
14. Howard L.S., Barson R.A., Howse B.P., McGill T.R., McIntyre M.E., O'Connor D.F., and Robbins P.A. Chamber for controlling end-tidal gas tensions over sustained periods in humans. J. Appl. Physiol. 78 (1995) 1088-1091
15. Hultgren H.N., Grover R.F., and Hartley L.H. Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation 44 (1971) 759-770
16. Janosi A., Apor P., Hankoczy J., and Kadar A. Pulmonary artery pressure and oxygen consumption measurement during supine bicycle exercise. Chest 93 (1988) 419-421
17. Knaupp W., Khilnani S., Sherwood J., Scharf S., and Steinberg H. Erythropoietin response to acute normobaric hypoxia in humans. J. Appl. Physiol. 73 (1992) 837-840
18. Modesti P.A., Vanni S., Morabito M., Modesti A., Marchetta M., Gamberi T., Sofi F., Savia G., Mancia G., Gensini G.F., and Parati G. Role of endothelin-1 in exposure to high altitude: acute mountain sickness and endothelin-1 (ACME-1) study. Circulation 114 (2006) 1410-1416
19. Morrell N.W., Nijran K.S., Biggs T., and Seed W.A. Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man. Respir. Physiol. 100 (1995) 271-281
20. Semenza G.L. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19 (2004) 176-182
21. Shimoda L.A., Manalo D.J., Sham J.S., Semenza G.L., and Sylvester J.T. Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 281 (2001) L202-208
22. Smith T.G., Brooks J.T., Balanos G.M., Lappin T.R., Layton D.M., Leedham D.L., Liu C., Maxwell P.H., McMullin M.F., McNamara C.J., Percy M.J., Pugh C.W., Ratcliffe P.J., Talbot N.P., Treacy M., and Robbins P.A. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med. 3 (2006) e290
23. Stenmark K.R., Fasules J., Hyde D.M., Voelkel N.F., Henson J., Tucker A., Wilson H., and Reeves J.T. Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. J. Appl. Physiol. 62 (1987) 821-830
24. Syyed R., Reeves J.T., Welsh D., Raeside D., Johnson M.K., and Peacock A.J. The relationship between the components of pulmonary artery pressure remains constant under all conditions in both health and disease. Chest 133 (2008) 633-639
25. Talbot N.P., Balanos G.M., Dorrington K.L., and Robbins P.A. Two temporal components within the human pulmonary vascular response to approximately 2 h of isocapnic hypoxia. J. Appl. Physiol. 98 (2005) 1125-1139
26. Wang G.L., and Semenza G.L. Characterization of Hypoxia-inducible Factor 1 and Regulation of DNA Binding Activity by Hypoxia. J. Biol. Chem. 268 (1993) 21513-21518
27. Yock P.G., and Popp R.L. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 70 (1984) 657-662
28. Yu A.Y., Shimoda L.A., Iyer N.V., Huso D.L., Sun X., McWilliams R., Beaty T., Sham J.S., Wiener C.M., Sylvester J.T., and Semenza G.L. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J. Clin. Invest. 103 (1999) 691-696