Damage control in host-pathogen interactions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 37, 2009, Pages 15525-15526

  Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; BILIVERDIN; CHLOROQUINE; HEME OXYGENASE 1; IBUPROFEN; REACTIVE OXYGEN METABOLITE;

ANTIMICROBIAL ACTIVITY; DISEASE CONTROL; DRUG MECHANISM; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFECTION PREVENTION; INFLUENZA; LIVER FAILURE; MALARIA; MICROBIAL COLONIZATION; MICROORGANISM; MORTALITY; NONHUMAN; NOTE; PLASMODIUM CHABAUDI INFECTION; PRIORITY JOURNAL; VIRUS INFECTION;

ANIMALS; APOPTOSIS; ERYTHROCYTES; HEME; HEME OXYGENASE-1; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; MALARIA; PLASMODIUM; REACTIVE OXYGEN SPECIES;

EID: 70349448075     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908451106     Document Type: Note

References (14)

1. Råberg L, Graham AL, Read AF (2009) Decomposing health: tolerance and resistance to parasites in animals. Philos Trans R Soc London Ser B 364:37-49.
2. Schneider DS, Ayres JS (2008) Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol 8:889-895.
3. Seixas E, et al. (2009) Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci USA 106:15837-15842.
4. Rausher MD (2001) Co-evolution and plant resistance to natural enemies. Nature 411:857-864. (Pubitemid 32588115)
5. Råberg L, Sim D, Read AF (2007) Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science 318:812-814.
6. Ayres JS, Freitag N, Schneider DS (2008) Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics 178:1807-1815.
7. Ayres JS, Schneider DS (2008) A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol 6:2764-2773.
8. Ayres JS, Schneider DS (2009) The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol 7:e1000150.
9. Gordon MD, Ayres JS, Schneider DS, Nusse R (2008) Pathogenesis of Listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog 4:e1000111.
10. Read AF, Graham AL, Råberg L (2008) Animal defenses against infectious agents: Is damage control more important than pathogen control. PLoS Biol 6:e4.
11. Miller LH, Baruch DI, Marsh K, Doumbo OK (2002) The pathogenic basis of malaria. Nature 415:673-679.
12. Balla J, et al. (1993) Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA 90:9285-9289. (Pubitemid 23315768)
13. Pamplona A, et al. (2007) Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med 13:703-710. (Pubitemid 46889755)
14. Figueiredo RT, et al. (2007) Characterization of heme as activator of Toll-like receptor 4. J Biol Chem 282:20221-20229.