메뉴 건너뛰기




Volumn 27, Issue 5, 2009, Pages 321-333

A serum free approach towards the conservation of chondrogenic phenotype during in vitro cell expansion

Author keywords

Chondrocytes and matrix associated autologous chondrocyte implantation; ECM coating; Serum free

Indexed keywords

AGGRECAN; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; PLATELET DERIVED GROWTH FACTOR AB; TRANSCRIPTION FACTOR SOX9;

EID: 70349413092     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190903137595     Document Type: Article
Times cited : (15)

References (51)
  • 1
    • 0038667428 scopus 로고    scopus 로고
    • Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes
    • Barbero A, Ploegert S, Heberer M, Martin I. 2003. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum 48(5):1315-1325.
    • (2003) Arthritis Rheum , vol.48 , Issue.5 , pp. 1315-1325
    • Barbero, A.1    Ploegert, S.2    Heberer, M.3    Martin, I.4
  • 2
    • 23244446145 scopus 로고    scopus 로고
    • Experimental and mathematical study of the influence of growth factors on the growth kinetics of adult human articular chondrocytes
    • Barbero A, Palumberi V, Wagner B, Sader R, Grote MJ, Martin I. 2005. Experimental and mathematical study of the influence of growth factors on the growth kinetics of adult human articular chondrocytes. J Cell Physiol 204(3):830-838.
    • (2005) J Cell Physiol , vol.204 , Issue.3 , pp. 830-838
    • Barbero, A.1    Palumberi, V.2    Wagner, B.3    Sader, R.4    Grote, M.J.5    Martin, I.6
  • 3
    • 33746426202 scopus 로고    scopus 로고
    • Expansion on specific substrates regulates the phenotype and differentiation capacity of human articular chondrocytes
    • Barbero A, Grogan SP, Mainil-Varlet P, Martin I. 2006. Expansion on specific substrates regulates the phenotype and differentiation capacity of human articular chondrocytes. J Cell Biochem 98(5):1140-1149.
    • (2006) J Cell Biochem , vol.98 , Issue.5 , pp. 1140-1149
    • Barbero, A.1    Grogan, S.P.2    Mainil-Varlet, P.3    Martin, I.4
  • 4
    • 18944373370 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study
    • Bartlett W, Skinner JA, Gooding CR, Carrington RW, Flanagan AM, Briggs TW, Bentley G. 2005. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study. J Bone Joint Surg 87(5):640-645.
    • (2005) J Bone Joint Surg , vol.87 , Issue.5 , pp. 640-645
    • Bartlett, W.1    Skinner, J.A.2    Gooding, C.R.3    Carrington, R.W.4    Flanagan, A.M.5    Briggs, T.W.6    Bentley, G.7
  • 5
    • 33746265054 scopus 로고    scopus 로고
    • Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)-5-year follow-up
    • Behrens P, Bitter T, Kurz B, Russlies M. 2006. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)-5-year follow-up. Knee 13(3):194-202.
    • (2006) Knee , vol.13 , Issue.3 , pp. 194-202
    • Behrens, P.1    Bitter, T.2    Kurz, B.3    Russlies, M.4
  • 6
    • 0026515992 scopus 로고
    • Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: The role of insulin-like growth factor-I, insulin, or thyroxine
    • Bohme K, Conscience-Egli M, Tschan T, Winterhalter KH, Bruckner P. 1992. Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: The role of insulin-like growth factor-I, insulin, or thyroxine. J Cell Biol 116(4): 1035-1042.
    • (1992) J Cell Biol , vol.116 , Issue.4 , pp. 1035-1042
    • Bohme, K.1    Conscience-Egli, M.2    Tschan, T.3    Winterhalter, K.H.4    Bruckner, P.5
  • 7
    • 0028031550 scopus 로고
    • Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
    • Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. 1994. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889-895.
    • (1994) N Engl J Med , vol.331 , Issue.14 , pp. 889-895
    • Brittberg, M.1    Lindahl, A.2    Nilsson, A.3    Ohlsson, C.4    Isaksson, O.5    Peterson, L.6
  • 8
    • 2942516395 scopus 로고    scopus 로고
    • Chondrocyte phenotypes on different extracellular matrix monolayers
    • Brodkin KR, Garcia AJ, Levenston ME. 2004. Chondrocyte phenotypes on different extracellular matrix monolayers. Biomaterials 25(28):5929-5938.
    • (2004) Biomaterials , vol.25 , Issue.28 , pp. 5929-5938
    • Brodkin, K.R.1    Garcia, A.J.2    Levenston, M.E.3
  • 9
    • 70349409898 scopus 로고    scopus 로고
    • Serum free medium for chondrocyte cells
    • United States Patent 6617159
    • Cancedda R. 2003. Serum free medium for chondrocyte cells. United States Patent 6617159.
    • (2003)
    • Cancedda, R.1
  • 10
    • 33845189890 scopus 로고    scopus 로고
    • Serum-free cultures of murine adrenal cortical cells
    • Chu Y, Wu BM, McCabe ER, Dunn JC. 2006. Serum-free cultures of murine adrenal cortical cells. J Pediatr Surg 41(12): 2008-2012.
    • (2006) J Pediatr Surg , vol.41 , Issue.12 , pp. 2008-2012
    • Chu, Y.1    Wu, B.M.2    McCabe, E.R.3    Dunn, J.C.4
  • 11
    • 0033835868 scopus 로고    scopus 로고
    • Cellular interactions and signaling in cartilage development
    • DeLise AM, Fischer L, Tuan RS. 2000. Cellular interactions and signaling in cartilage development. Osteoarthr Cartil 8(5): 309-334.
    • (2000) Osteoarthr Cartil , vol.8 , Issue.5 , pp. 309-334
    • DeLise, A.M.1    Fischer, L.2    Tuan, R.S.3
  • 12
    • 36849043173 scopus 로고    scopus 로고
    • Immunophenotypic changes of human articular chondrocytes during monolayer culture reflect bona fide dedifferentiation rather than amplification of progenitor cells
    • Diaz-Romero J, Nesic D, Grogan SP, Heini P, Mainil-Varlet P. 2008. Immunophenotypic changes of human articular chondrocytes during monolayer culture reflect bona fide dedifferentiation rather than amplification of progenitor cells. J Cell Physiol 214(1):75-83.
    • (2008) J Cell Physiol , vol.214 , Issue.1 , pp. 75-83
    • Diaz-Romero, J.1    Nesic, D.2    Grogan, S.P.3    Heini, P.4    Mainil-Varlet, P.5
  • 13
    • 33644506732 scopus 로고    scopus 로고
    • Serum-free hybridoma culture: Ethical, scientific and safety considerations
    • Even MS, Sandusky CB, Barnard ND. 2006. Serum-free hybridoma culture: Ethical, scientific and safety considerations. Trends Biotechnol 24(3):105-108.
    • (2006) Trends Biotechnol , vol.24 , Issue.3 , pp. 105-108
    • Even, M.S.1    Sandusky, C.B.2    Barnard, N.D.3
  • 14
    • 20944451379 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation (ACI) for aged patients: Development of the proper cell expansion conditions for possible therapeutic applications
    • Giannoni P, Pagano A, Maggi E, Arbico R, Randazzo N, Grandizio M, Cancedda R, Dozin B. 2005. Autologous chondrocyte implantation (ACI) for aged patients: Development of the proper cell expansion conditions for possible therapeutic applications. Osteoarthr Cartil 13(7):589-600.
    • (2005) Osteoarthr Cartil , vol.13 , Issue.7 , pp. 589-600
    • Giannoni, P.1    Pagano, A.2    Maggi, E.3    Arbico, R.4    Randazzo, N.5    Grandizio, M.6    Cancedda, R.7    Dozin, B.8
  • 15
    • 33747438871 scopus 로고    scopus 로고
    • Gissel C, DossMX, Hippler-Altenburg R, Hescheler J, Sachinidis A. 2006. Generation and characterization of cardiomyocytes under serum-free conditions. Methods Mol Biol 330:191-219. Glaser JH, Conrad HE. 1984. Properties of chick embryo chondrocytes grown in serum-free medium. J Biol Chem 259(11):6766-6772.
    • Gissel C, DossMX, Hippler-Altenburg R, Hescheler J, Sachinidis A. 2006. Generation and characterization of cardiomyocytes under serum-free conditions. Methods Mol Biol 330:191-219. Glaser JH, Conrad HE. 1984. Properties of chick embryo chondrocytes grown in serum-free medium. J Biol Chem 259(11):6766-6772.
  • 17
    • 0035992496 scopus 로고    scopus 로고
    • Recent advances in TGFbeta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders
    • Grimaud E, Heymann D, Redini F. 2002. Recent advances in TGFbeta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders. Cytokine Growth Factor Rev 13(3):241-257.
    • (2002) Cytokine Growth Factor Rev , vol.13 , Issue.3 , pp. 241-257
    • Grimaud, E.1    Heymann, D.2    Redini, F.3
  • 18
    • 1542495520 scopus 로고    scopus 로고
    • Alternatives to the use of fetal bovine serum: Serum-free cell culture
    • Gstraunthaler G. 2003. Alternatives to the use of fetal bovine serum: Serum-free cell culture. ALTEX 20(4):275-281.
    • (2003) ALTEX , vol.20 , Issue.4 , pp. 275-281
    • Gstraunthaler, G.1
  • 19
    • 0022970695 scopus 로고
    • Development of a new serum-free medium, USC-HC1, for growth and normal phenotype in postembryonic chicken growth plate chondrocytes
    • Hale LV, Hale JE, Kemick ML, Ishikawa Y, Wuthier RE. 1986. Development of a new serum-free medium, USC-HC1, for growth and normal phenotype in postembryonic chicken growth plate chondrocytes. In vitro Cell Dev Biol 22(10):597-603.
    • (1986) In vitro Cell Dev Biol , vol.22 , Issue.10 , pp. 597-603
    • Hale, L.V.1    Hale, J.E.2    Kemick, M.L.3    Ishikawa, Y.4    Wuthier, R.E.5
  • 20
    • 33847067890 scopus 로고    scopus 로고
    • Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium
    • Heber S, Denk L, Hu K, Minuth WW. 2007. Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium. Tissue Eng 13(2):281-292.
    • (2007) Tissue Eng , vol.13 , Issue.2 , pp. 281-292
    • Heber, S.1    Denk, L.2    Hu, K.3    Minuth, W.W.4
  • 21
    • 0032532803 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation and maturation
    • Hickok NJ, Haas AR, Tuan RS. 1998. Regulation of chondrocyte differentiation and maturation. Microsc Res Tech 43(2): 174-190.
    • (1998) Microsc Res Tech , vol.43 , Issue.2 , pp. 174-190
    • Hickok, N.J.1    Haas, A.R.2    Tuan, R.S.3
  • 22
    • 0037354981 scopus 로고    scopus 로고
    • Serum-free culture of murine primordial germ cells and embryonic germ cells
    • Horii T, Nagao Y, Tokunaga T, Imai H. 2003. Serum-free culture of murine primordial germ cells and embryonic germ cells. Theriogenology 59(5-6):1257-1264.
    • (2003) Theriogenology , vol.59 , Issue.5-6 , pp. 1257-1264
    • Horii, T.1    Nagao, Y.2    Tokunaga, T.3    Imai, H.4
  • 23
    • 34547119052 scopus 로고    scopus 로고
    • Expression profiling of dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development
    • James CG, Ulici V, Tuckermann J, Underhill TM, Beier F. 2007. Expression profiling of dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development. BMC Genomics 8:205.
    • (2007) BMC Genomics , vol.8 , pp. 205
    • James, C.G.1    Ulici, V.2    Tuckermann, J.3    Underhill, T.M.4    Beier, F.5
  • 24
    • 31644440253 scopus 로고    scopus 로고
    • Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    • Kaul G, Cucchiarini M, Arntzen D, Zurakowski D, Menger MD, Kohn D, Trippel SB, Madry H. 2006. Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo. J Gene Med 8(1):100-111.
    • (2006) J Gene Med , vol.8 , Issue.1 , pp. 100-111
    • Kaul, G.1    Cucchiarini, M.2    Arntzen, D.3    Zurakowski, D.4    Menger, M.D.5    Kohn, D.6    Trippel, S.B.7    Madry, H.8
  • 25
    • 0030885581 scopus 로고    scopus 로고
    • Platelet derived growth factor stimulates chondrocyte proliferation but prevents endochondral maturation
    • Kieswetter K, Schwartz Z, AldereteM, Dean DD, Boyan BD. 1997. Platelet derived growth factor stimulates chondrocyte proliferation but prevents endochondral maturation. Endocrine 6(3):257-264.
    • (1997) Endocrine , vol.6 , Issue.3 , pp. 257-264
    • Kieswetter, K.1    Schwartz, Z.2    Alderete, M.3    Dean, D.D.4    Boyan, B.D.5
  • 26
    • 0035058082 scopus 로고    scopus 로고
    • Smooth muscle actin expression by human articular chondrocytes and their contraction of a collagen-glycosaminoglycan matrix in vitro
    • Kinner B, Spector M. 2001. Smooth muscle actin expression by human articular chondrocytes and their contraction of a collagen-glycosaminoglycan matrix in vitro. J Orthop Res 19(2):233-241.
    • (2001) J Orthop Res , vol.19 , Issue.2 , pp. 233-241
    • Kinner, B.1    Spector, M.2
  • 27
    • 17644384516 scopus 로고    scopus 로고
    • Subculture of chondrocytes on a collagen type I-coated substrate with suppressed cellular dedifferentiation
    • Kino-Oka M, Yashiki S, Ota Y, Mushiaki Y, Sugawara K, Yamamoto T, Takezawa T, Taya M. 2005. Subculture of chondrocytes on a collagen type I-coated substrate with suppressed cellular dedifferentiation. Tissue Eng 11(3-4):597-608.
    • (2005) Tissue Eng , vol.11 , Issue.3-4 , pp. 597-608
    • Kino-Oka, M.1    Yashiki, S.2    Ota, Y.3    Mushiaki, Y.4    Sugawara, K.5    Yamamoto, T.6    Takezawa, T.7    Taya, M.8
  • 28
    • 0037195522 scopus 로고    scopus 로고
    • Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes
    • Koedam JA, Smink JJ, van Buul-Offers SC. 2002. Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes. Mol Cell Endocrinol 197(1-2):35-44.
    • (2002) Mol Cell Endocrinol , vol.197 , Issue.1-2 , pp. 35-44
    • Koedam, J.A.1    Smink, J.J.2    van Buul-Offers, S.C.3
  • 29
    • 0034777927 scopus 로고    scopus 로고
    • Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor
    • Kolettas E, Muir HI, Barrett JC, Hardingham TE. 2001. Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. Rheumatology 40(10):1146-1156.
    • (2001) Rheumatology , vol.40 , Issue.10 , pp. 1146-1156
    • Kolettas, E.1    Muir, H.I.2    Barrett, J.C.3    Hardingham, T.E.4
  • 30
    • 33847225869 scopus 로고    scopus 로고
    • Krejci P, Krakow D, Mekikian PB, Wilcox WR. 2007. Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage. Pediatr Res 61(3):267-272.
    • Krejci P, Krakow D, Mekikian PB, Wilcox WR. 2007. Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage. Pediatr Res 61(3):267-272.
  • 31
    • 1042266503 scopus 로고    scopus 로고
    • Serum-free growth medium sustains commitment of human articular chondrocyte through maintenance of Sox9 expression
    • Malpeli M, Randazzo N, Cancedda R, Dozin B. 2004. Serum-free growth medium sustains commitment of human articular chondrocyte through maintenance of Sox9 expression. Tissue Eng 10(1-2):145-155.
    • (2004) Tissue Eng , vol.10 , Issue.1-2 , pp. 145-155
    • Malpeli, M.1    Randazzo, N.2    Cancedda, R.3    Dozin, B.4
  • 32
    • 0035988711 scopus 로고    scopus 로고
    • Serum-free medium supplemented with high-concentration FGF2 for cell expansion culture of human ear chondrocytes promotes redifferentiation capacity
    • Mandl EW, van der Veen SW, Verhaar JA, van Osch GJ. 2002. Serum-free medium supplemented with high-concentration FGF2 for cell expansion culture of human ear chondrocytes promotes redifferentiation capacity. Tissue Eng 8(4):573-580.
    • (2002) Tissue Eng , vol.8 , Issue.4 , pp. 573-580
    • Mandl, E.W.1    van der Veen, S.W.2    Verhaar, J.A.3    van Osch, G.J.4
  • 33
    • 1042289611 scopus 로고    scopus 로고
    • Multiplication of human chondrocytes with low seeding densities accelerates cell yield without losing redifferentiation capacity
    • Mandl EW, van der Veen SW, Verhaar JA, van Osch GJ. 2004. Multiplication of human chondrocytes with low seeding densities accelerates cell yield without losing redifferentiation capacity. Tissue Eng 10(1-2):109-118.
    • (2004) Tissue Eng , vol.10 , Issue.1-2 , pp. 109-118
    • Mandl, E.W.1    van der Veen, S.W.2    Verhaar, J.A.3    van Osch, G.J.4
  • 34
    • 30444461215 scopus 로고    scopus 로고
    • Cartilage repair: Generations of autologous chondrocyte transplantation
    • Marlovits S, Zeller P, Singer P, Resinger C, Vecsei V. 2006. Cartilage repair: Generations of autologous chondrocyte transplantation. Eur J Radiol 57(1):24-31.
    • (2006) Eur J Radiol , vol.57 , Issue.1 , pp. 24-31
    • Marlovits, S.1    Zeller, P.2    Singer, P.3    Resinger, C.4    Vecsei, V.5
  • 35
    • 0030885841 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow
    • Martin I, Muraglia A, Campanile G, Cancedda R, Quarto R. 1997. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138(10):4456-4462.
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4456-4462
    • Martin, I.1    Muraglia, A.2    Campanile, G.3    Cancedda, R.4    Quarto, R.5
  • 36
    • 0034838821 scopus 로고    scopus 로고
    • Enhanced cartilage tissue engineering by sequential exposure of chondrocytes to FGF-2 during 2D expansion and BMP-2 during 3D cultivation
    • Martin I, Suetterlin R, Baschong W, Heberer M, Vunjak-Novakovic G, Freed LE. 2001. Enhanced cartilage tissue engineering by sequential exposure of chondrocytes to FGF-2 during 2D expansion and BMP-2 during 3D cultivation. J Cell Biochem 83(1):121-128.
    • (2001) J Cell Biochem , vol.83 , Issue.1 , pp. 121-128
    • Martin, I.1    Suetterlin, R.2    Baschong, W.3    Heberer, M.4    Vunjak-Novakovic, G.5    Freed, L.E.6
  • 38
    • 0033974686 scopus 로고    scopus 로고
    • Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
    • Murakami S, Kan M, McKeehan WL, de Crombrugghe B. 2000. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 97(3):1113-1118.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.3 , pp. 1113-1118
    • Murakami, S.1    Kan, M.2    McKeehan, W.L.3    de Crombrugghe, B.4
  • 39
    • 34247257351 scopus 로고    scopus 로고
    • Serum-free cell culture - the ethical, scientist and economic choice
    • Newman C. 2003. Serum-free cell culture - the ethical, scientist and economic choice. Biomed Sci: 941-942.
    • (2003) Biomed Sci , pp. 941-942
    • Newman, C.1
  • 40
    • 0032509782 scopus 로고    scopus 로고
    • Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites
    • Ribault D, Habib M, Abdel-Majid K, Barbara A, Mitrovic D. 1998. Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites. Mech Ageing Dev 100(1):25-40.
    • (1998) Mech Ageing Dev , vol.100 , Issue.1 , pp. 25-40
    • Ribault, D.1    Habib, M.2    Abdel-Majid, K.3    Barbara, A.4    Mitrovic, D.5
  • 41
    • 0142151440 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation for cartilage repair: Monitoring its success by magnetic resonance imaging and histology
    • Roberts S, McCall IW, Darby AJ, Menage J, Evans H, Harrison PE, Richardson JB. 2003. Autologous chondrocyte implantation for cartilage repair: Monitoring its success by magnetic resonance imaging and histology. Arthritis Res Ther 5(1):R60-R73.
    • (2003) Arthritis Res Ther , vol.5 , Issue.1
    • Roberts, S.1    McCall, I.W.2    Darby, A.J.3    Menage, J.4    Evans, H.5    Harrison, P.E.6    Richardson, J.B.7
  • 42
    • 0036158068 scopus 로고    scopus 로고
    • Temporal expression of CD44 during embryonic chick limb development and modulation of expression with retinoic acid
    • Rousche KT, Knudson CB. 2002. Temporal expression of CD44 during embryonic chick limb development and modulation of expression with retinoic acid. Matrix Biol 21(1):53-62.
    • (2002) Matrix Biol , vol.21 , Issue.1 , pp. 53-62
    • Rousche, K.T.1    Knudson, C.B.2
  • 44
    • 33646125855 scopus 로고    scopus 로고
    • A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair
    • Schmidt MB, Chen EH, Lynch SE. 2006. A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthr Cartil 14(5):403-412.
    • (2006) Osteoarthr Cartil , vol.14 , Issue.5 , pp. 403-412
    • Schmidt, M.B.1    Chen, E.H.2    Lynch, S.E.3
  • 46
    • 0027998282 scopus 로고
    • Immunohistochemical analysis of EGF in epiphyseal growth plate from normal, hypophysectomized, and growth hormonetreated hypophysectomized rats
    • Tajima Y, Kato K, Kashimata M, Hiramatsu M, Utsumi N. 1994. Immunohistochemical analysis of EGF in epiphyseal growth plate from normal, hypophysectomized, and growth hormonetreated hypophysectomized rats. Cell Tissue Res 278(2): 279-282.
    • (1994) Cell Tissue Res , vol.278 , Issue.2 , pp. 279-282
    • Tajima, Y.1    Kato, K.2    Kashimata, M.3    Hiramatsu, M.4    Utsumi, N.5
  • 49
    • 0035881709 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes
    • Zaucke F, Dinser R, Maurer P, Paulsson M. 2001. Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes. Biochem J 358(Pt 1):17-24.
    • (2001) Biochem J , vol.358 , Issue.PART 1 , pp. 17-24
    • Zaucke, F.1    Dinser, R.2    Maurer, P.3    Paulsson, M.4
  • 50
    • 33750019223 scopus 로고    scopus 로고
    • Proteomic analysis for the assessment of different lots of fetal bovine serum as a raw material for cell culture. Part IV. Application of proteomics to the manufacture of biological drugs
    • Zheng X, Baker H, Hancock WS, Fawaz F, McCaman M, Pungor E, Jr. 2006. Proteomic analysis for the assessment of different lots of fetal bovine serum as a raw material for cell culture. Part IV. Application of proteomics to the manufacture of biological drugs. Biotechnol Prog 22(5):1294-1300.
    • (2006) Biotechnol Prog , vol.22 , Issue.5 , pp. 1294-1300
    • Zheng, X.1    Baker, H.2    Hancock, W.S.3    Fawaz, F.4    McCaman, M.5    Pungor Jr., E.6
  • 51
    • 0017723046 scopus 로고
    • Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
    • von der Mark K, Gauss V, von der Mark H, Muller P. 1977. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature 267(5611):531-532.
    • (1977) Nature , vol.267 , Issue.5611 , pp. 531-532
    • von der Mark, K.1    Gauss, V.2    von der Mark, H.3    Muller, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.