Characteristics and impact of sedation, analgesia, and neuromuscular blockage in critical patients undergoing prolonged mechanical ventilation;Características e impacto de la sedación, la analgesia y el bloqueo neuromuscular en los pacientes críticos que recibieron ventilación mecánica prolongada

Medicina Intensiva

Volumn 33, Issue 7, 2009, Pages 311-320

  Tobar, E ^a   Bugedo, G ^b   Andresen, M ^b   Aguirre, M ^b   Lira, M T ^b   Godoy, J ^c   Gonzalez H ^d   Hernandez A ^e   Tomicic, V ^f   Castro, J ^g   Jara, J ^h   Ugarte, H ⁱ  

^a HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c HOSPITAL DR SÓTERO DEL RÍO   (Chile)

^d HOSPITAL SAN JUAN DE DIOS   (Chile)

^e HOSPITAL MILITAR DE SANTIAGO   (Chile)

^f UNIVERSIDAD DEL DESARROLLO   (Chile)

^g HOSPITAL DIPRECA   (Chile)

^h HOSPITAL REGIONAL DE TALCA   (Chile)

ⁱ Hospital de San Pablo   (Chile)

Author keywords

Critical patient; Intensive care units; Neuromuscular blocking agents; Sedation

Indexed keywords

ANALGESIC AGENT; FENTANYL; LORAZEPAM; MIDAZOLAM; MORPHINE; NEUROMUSCULAR BLOCKING AGENT; PROPOFOL; SEDATIVE AGENT;

ACUTE LUNG INJURY; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ANALGESIA; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CHILE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROMUSCULAR BLOCKING; OBSERVATIONAL STUDY; RATING SCALE; SEDATION; SEPSIS;

AGED; ANALGESIA; COHORT STUDIES; CONSCIOUS SEDATION; CRITICAL ILLNESS; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE BLOCK; RESPIRATION, ARTIFICIAL;

EID: 70349411499     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2009.04.001     Document Type: Article

References (40)

1. Burchardi H. Aims of sedation/analgesia. Minerva Anestesiol 70 (2004) 137-143
2. Kress J.P., and Hall J.B. Sedation in the mechanically ventilated patient. Crit Care Med 34 (2006) 2541-2546
3. Kollef M.H., Levy N.T., Ahrens T.S., Schaiff R., Prentice D., and Sherman G. The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest 114 (1998) 541-548
4. Schweickert W.D., Gehlbach B.K., Pohlman A.S., Hall J.B., and Kress J.P. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 32 (2004) 1272-1276
5. Arroliga A., Frutos-Vivar F., Hall J., Esteban A., Apezteguia C., Soto L., et al. Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation. Chest 128 (2005) 496-506
6. Cook D.J., Walter S.D., Cook R.J., Griffith L.E., Guyatt G.H., Leasa D., et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129 (1998) 433-440
7. Pandharipande P., Shintani A., Peterson J., Pun B.T., Wilkinson G.R., Dittus R.S., et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104 (2006) 21-26
8. Pandharipande P., Cotton B.A., Shintani A., Thompson J., Pun B.T., Morris Jr. J.A., et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 65 (2008) 34-41
9. Garnacho-Montero J., Madrazo-Osuna J., García-Garmendia J.L., Ortiz-Leyba C., Jiménez-Jiménez F.J., Barrero-Almodovar A., et al. Critical illness polyneuropathy: Risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 27 (2001) 1288-1296
10. Schweickert W.D., and Hall J. ICU-acquired weakness. Chest 131 (2007) 1541-1549
11. Brattebo G., Hofoss D., Flaatten H., Muri A.K., Gjerde S., and Plsek P.E. Effect of a scoring system and protocol for sedation on duration of patients' need for ventilator support in a surgical intensive care unit. BMJ 324 (2002) 1386-1389
12. Burns S.M., Earven S., Fisher C., Lewis R., Merrell P., Schubart J.R., et al. Implementation of an institutional program to improve clinical and financial outcomes of mechanically ventilated patients: One-year outcomes and lessons learned. Crit Care Med 31 (2003) 2752-2763
13. Holcomb B.W., Wheeler A.P., and Ely E.W. New ways to reduce unnecessary variation and improve outcomes in the intensive care unit. Curr Opin Crit Care 7 (2001) 304-311
14. Mascia M.F., Koch M., and Medicis J.J. Pharmacoeconomic impact of rational use guidelines on the provision of analgesia, sedation, and neuromuscular blockade in critical care. Crit Care Med 28 (2000) 2300-2306
15. Brook A.D., Ahrens T.S., Schaiff R., Prentice D., Sherman G., Shannon W., et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med 27 (1999) 2609-2615
16. Kress J.P., Pohlman A.S., O'Connor M.F., and Hall J.B. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342 (2000) 1471-1477
17. De Jonghe B., Bastuji-Garin S., Fangio P., Lacherade J.C., Jabot J., Appere-de-Vecchi C., et al. Sedation algorithm in critically ill patients without acute brain injury. Crit Care Med 33 (2005) 120-127
18. Murdoch S., and Cohen A. Intensive care sedation: A review of current British practice. Intensive Care Med 26 (2000) 922-928
19. Soliman H.M., Melot C., and Vincent J.L. Sedative and analgesic practice in the intensive care unit: The results of a European survey. Br J Anaesth 87 (2001) 186-192
20. Martin J., Franck M., Fischer M., and Spies C. Sedation and analgesia in German intensive care units: How is it done in reality? Results of a patient-based survey of analgesia and sedation. Intensive Care Med 32 (2006) 1137-1142
21. Mehta S., Burry L., Fischer S., Martínez-Motta J.C., Hallett D., Bowman D., et al. Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med 34 (2006) 374-380
22. Payen J.F., Chanques G., Mantz J., Hercule C., Auriant I., Leguillou J.L., et al. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: A prospective multicenter patient-based study. Anesthesiology 106 (2007) 687-695
23. Nasraway Jr. S.A. Use of sedative medications in the intensive care unit. Semin Respir Crit Care Med 22 (2001) 165-174
24. Estebanez-Montiel M.B., Alonso-Fernández M.A., Sandiumenge A., and Jiménez-Martin M.J. Prolonged sedation in intensive care units. Med Intensiva 32 (2008) 19-30
25. Sandiumenge A. Recommendations of the Analgesia and Sedation Group of SEMICYUC for sedation/analgesia and neuromuscular blocking in the critical patient. Presentation. Med Intensiva 32 (2008) 1-2
26. Tobar A.E., Lanas M.A., Pino P.S., Aspée L.P., Rivas V.S., Prat R.D., et al. Protocol based sedation versus conventional treatment in critically ill patients on mechanical ventilation. Rev Med Chil 136 (2008) 711-718
27. Spina S.P., and Ensom M.H. Clinical pharmacokinetic monitoring of midazolam in critically ill patients. Pharmacotherapy 27 (2007) 389-398
28. Bremer F., Reulbach U., Schwilden H., and Schuttler J. Midazolam therapeutic drug monitoring in intensive care sedation: A 5-year survey. Ther Drug Monit 26 (2004) 643-649
29. Riker R.R., Picard J.T., and Fraser G.L. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med 27 (1999) 1325-1329
30. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31 (2003) 1250-1256
31. Bernard G.R., Artigas A., Brigham K.L., Carlet J., Falke K., Hudson L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149 (1994) 818-824
32. Knaus W.A., Draper E.A., Wagner D.P., and Zimmerman J.E. APACHE II: A severity of disease classification system. Crit Care Med 13 (1985) 818-829
33. Nasraway Jr. S.A., Jacobi J., Murray M.J., and Lumb P.D. Sedation, analgesia, and neuromuscular blockade of the critically ill adult: Revised clinical practice guidelines for 2002. Crit Care Med 30 (2002) 117-118
34. Arroliga A.C., Thompson B.T., Ancukiewicz M., Gonzales J.P., Guntupalli K.K., Park P.K., et al. Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med 36 (2008) 1083-1088
35. Esteban A., Fernández-Segoviano P., Frutos-Vivar F., Aramburu J., Nájera L., Ferguson N., et al. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 141 (2004) 440-445
36. Peñuelas O., Esteban A., Frutos-Vivar F., and Aramburu J. Validez de los criterios diagnósticos del síndrome de distrés respiratorio agudo. Med Intensiva 30 (2006) 212-217
37. Forel J.M., Roch A., Marin V., Michelet P., Demory D., Blache J.L., et al. Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med 34 (2006) 2749-2757
38. Romero C.M., Cornejo R.A., Gálvez L.R., Llanos O.P., Tobar E.A., Berasaín M.A., et al. Extended prone position ventilation in severe acute respiratory distress syndrome: A pilot feasibility study. J Crit Care 24 (2009) 81-88
39. Murray M.J., Brull S.J., and Bolton C.F. Brief review: Non depolarizing neuromuscular blocking drugs and critical illness myopathy. Can J Anaesth 53 (2006) 1148-1156
40. Ely E.W., Shintani A., Truman B., Speroff T., Gordon S.M., Harrell Jr. F.E., et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291 (2004) 1753-1762