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Volumn 10, Issue 15, 2009, Pages 2545-2554

Besifloxacin, a new ophthalmic fluoroquinolone for the treatment of bacterial conjunctivitis

Author keywords

Bacterial conjunctivitis; Bacterial resistance; Besifloxacin ophthalmic suspension 0.6 ; Besivance ; Fluoroquinolone

Indexed keywords

AZITHROMYCIN; BESIFLOXACIN; BESIVANCE; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; GATIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TOBRAMYCIN; UNCLASSIFIED DRUG;

EID: 70349397427     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656560903213413     Document Type: Review
Times cited : (18)

References (49)
  • 1
    • 39349090858 scopus 로고    scopus 로고
    • Acute bacterial conjunctivitis
    • Hovding G. Acute bacterial conjunctivitis. Acta Ophthalmol 2008;86:5-17
    • (2008) Acta Ophthalmol , vol.86 , pp. 5-17
    • Hovding, G.1
  • 2
    • 34548225098 scopus 로고    scopus 로고
    • Management strategies for acute infective conjunctivitis in primary care: A systematic review
    • DOI 10.1517/14656566.8.12.1903
    • Rose P. Management strategies for acute infective conjunctivitis in primary care: a systematic review. Expert Opin Pharmacother 2007;8:1903-1921 (Pubitemid 47316148)
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.12 , pp. 1903-1921
    • Rose, P.1
  • 3
    • 0023980233 scopus 로고
    • The red eye. Infectious conjunctivitis, keratitis, endophthalmitis, and periocular cellulitis
    • Wilhelmus KR. The red eye. Infectious conjunctivitis, keratitis, endophthalmitis, and periocular cellulitis. Infect Syndr Head Neck 1988;2:99-116
    • (1988) Infect Syndr Head Neck , vol.2 , pp. 99-116
    • Wilhelmus, K.R.1
  • 5
    • 33745029542 scopus 로고    scopus 로고
    • Antibiotics versus placebo for acute bacterial conjunctivitis
    • CD001211
    • Sheikh A, Hurwitz B. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev 2006;2:CD001211
    • (2006) Cochrane Database Syst Rev , vol.2
    • Sheikh, A.1    Hurwitz, B.2
  • 7
    • 34247539126 scopus 로고    scopus 로고
    • Exclusion of students with conjunctivitis from school: Policies of state departments of health
    • Ohnsman CM. Exclusion of students with conjunctivitis from school: policies of state departments of health. J Pediatr Ophthalmol Strabismus 2007;44:101-105
    • (2007) J Pediatr Ophthalmol Strabismus , vol.44 , pp. 101-105
    • Ohnsman, C.M.1
  • 9
    • 1542603083 scopus 로고    scopus 로고
    • Fluoroquinolones: Mechanism of action, classification, and development of resistance
    • Blondeau JM. Fluoroquinolones: mechanism of action, classification, and development of resistance. Surv Ophthalmol 2004;49(Suppl 2):S73-8
    • (2004) Surv Ophthalmol , vol.49 , Issue.SUPPL. 2
    • Blondeau, J.M.1
  • 10
    • 3242730154 scopus 로고    scopus 로고
    • Fourth-generation fluoroquinolones: New topical agents in the war on ocular bacterial infections
    • Mah FS. Fourth-generation fluoroquinolones: new topical agents in the war on ocular bacterial infections. Curr Opin Ophthalmol 2004;15:316-320
    • (2004) Curr Opin Ophthalmol , vol.15 , pp. 316-320
    • Mah, F.S.1
  • 11
    • 61749103182 scopus 로고    scopus 로고
    • Review of third- And fourth-generation fluoroquinolones in ophthalmology: In vitro and in vivo efficacy
    • Scoper SV. Review of third- and fourth-generation fluoroquinolones in ophthalmology: in vitro and in vivo efficacy. Adv Ther 2008;25:979-994
    • (2008) Adv Ther , vol.25 , pp. 979-994
    • Scoper, S.V.1
  • 12
    • 43949112605 scopus 로고    scopus 로고
    • Ocular TRUST: Nationwide antimicrobial susceptibility patterns in ocular isolates
    • Asbell PA, Colby KA, Deng S, et al. Ocular TRUST: nationwide antimicrobial susceptibility patterns in ocular isolates. Am J Ophthalmol 2008;145:951-958
    • (2008) Am J Ophthalmol , vol.145 , pp. 951-958
    • Asbell, P.A.1    Colby, K.A.2    Deng, S.3
  • 13
    • 42949133281 scopus 로고    scopus 로고
    • Increasing prevalence of methicillin resistance in serious ocular infections caused by Staphylococcus aureus in the United States: 2000 to 2005
    • Asbell PA, Sahm DF, Shaw M, et al. Increasing prevalence of methicillin resistance in serious ocular infections caused by Staphylococcus aureus in the United States: 2000 to 2005. J Cataract Refract Surg 2008;34:814-818
    • (2008) J Cataract Refract Surg , vol.34 , pp. 814-818
    • Asbell, P.A.1    Sahm, D.F.2    Shaw, M.3
  • 14
    • 33947686663 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus infections of the eye and orbit
    • an American Ophthalmological Society thesis
    • Blomquist PH. Methicillin-resistant Staphylococcus aureus infections of the eye and orbit (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 2006;104:322-345
    • (2006) Trans Am Ophthalmol Soc , vol.104 , pp. 322-345
    • Blomquist, P.H.1
  • 15
    • 0037865212 scopus 로고    scopus 로고
    • Immunomodulatory effects of quinolones
    • Dalhoff A, Shalit I. Immunomodulatory effects of quinolones. Lancet Infect Dis 2003;3:359-371
    • (2003) Lancet Infect Dis , vol.3 , pp. 359-371
    • Dalhoff, A.1    Shalit, I.2
  • 16
    • 1542708136 scopus 로고    scopus 로고
    • Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones
    • Hwang DG. Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones. Surv Ophthalmol 2004;49(Suppl 2):S79-83
    • (2004) Surv Ophthalmol , vol.49 , Issue.SUPPL. 2
    • Hwang, D.G.1
  • 18
    • 37349094346 scopus 로고    scopus 로고
    • Update on bacterial conjunctivitis in South Florida
    • Cavuoto K, Zutshi D, Karp CL, et al. Update on bacterial conjunctivitis in South Florida. Ophthalmology 2008;115:51-56
    • (2008) Ophthalmology , vol.115 , pp. 51-56
    • Cavuoto, K.1    Zutshi, D.2    Karp, C.L.3
  • 19
    • 33645869540 scopus 로고    scopus 로고
    • In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates
    • Miller D, Flynn PM, Scott IU, et al. In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates. Arch Ophthalmol 2006;124:479-483
    • (2006) Arch Ophthalmol , vol.124 , pp. 479-483
    • Miller, D.1    Flynn, P.M.2    Scott, I.U.3
  • 20
    • 33745235120 scopus 로고    scopus 로고
    • Pharmacodynamics: Relation to antimicrobial resistance
    • Rybak MJ. Pharmacodynamics: relation to antimicrobial resistance. Am J Infect Control 2006;34:S38-45
    • (2006) Am J Infect Control , vol.34
    • Rybak, M.J.1
  • 21
    • 24944432186 scopus 로고    scopus 로고
    • Clinical and bacterial characteristics of acute bacterial conjunctivitis in children in the antibiotic resistance era
    • DOI 10.1097/01.inf.0000178066.24569.98
    • Buznach N, Dagan R, Greenberg D. Clinical and bacterial characteristics of acute bacterial conjunctivitis in children in the antibiotic resistance era. Pediatr Infect Dis J 2005;24:823-828 (Pubitemid 41324892)
    • (2005) Pediatric Infectious Disease Journal , vol.24 , Issue.9 , pp. 823-828
    • Buznach, N.1    Dagan, R.2    Greenberg, D.3
  • 22
    • 34547354966 scopus 로고    scopus 로고
    • Resistance to ocular antibiotics: An overview
    • Brown L. Resistance to ocular antibiotics: an overview. Clin Exp Optom 2007;90:258-262
    • (2007) Clin Exp Optom , vol.90 , pp. 258-262
    • Brown, L.1
  • 23
    • 34250800221 scopus 로고    scopus 로고
    • Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use
    • Ward KW, Lepage J-F, Driot J-Y. Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use. J Ocul Pharmacol Ther 2007;23:243-256
    • (2007) J Ocul Pharmacol Ther , vol.23 , pp. 243-256
    • Ward, K.W.1    Lepage, J.-F.2    Driot, J.-Y.3
  • 24
    • 21844477302 scopus 로고    scopus 로고
    • Mechanisms of resistance to quinolones
    • Jacoby GA. Mechanisms of resistance to quinolones. Clin Infect Dis 2005;41(Suppl 2):S120-6
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 2
    • Jacoby, G.A.1
  • 25
    • 60649093308 scopus 로고    scopus 로고
    • Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli
    • Cambau E, Matrat S, Pan XS, et al. Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother 2009;63:443-450
    • (2009) J Antimicrob Chemother , vol.63 , pp. 443-450
    • Cambau, E.1    Matrat, S.2    Pan, X.S.3
  • 26
    • 0036146667 scopus 로고    scopus 로고
    • Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones
    • Yague G, Morris JE, Pan X-S, et al. Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones. Antimicrob Agents Chemother 2002;46:413-419
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 413-419
    • Yague, G.1    Morris, J.E.2    Pan, X.-S.3
  • 27
    • 57649115466 scopus 로고    scopus 로고
    • Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells
    • Zhang J-Z, Cavet ME, Ward KW. Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells. Curr Eye Res 2008;33:923-932
    • (2008) Curr Eye Res , vol.33 , pp. 923-932
    • Zhang, J.-Z.1    Cavet, M.E.2    Ward, K.W.3
  • 28
    • 37549031303 scopus 로고    scopus 로고
    • Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes
    • Zhang J-Z, Ward KW. Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes. J Antimicrob Chemother 2008;61:111-116
    • (2008) J Antimicrob Chemother , vol.61 , pp. 111-116
    • Zhang, J.-Z.1    Ward, K.W.2
  • 29
    • 34648843446 scopus 로고    scopus 로고
    • Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis
    • Protzko E, Bowman L, Abelson M, et al. Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis. Invest Ophthalmol Vis Sci 2007;48:3425-3429
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3425-3429
    • Protzko, E.1    Bowman, L.2    Abelson, M.3
  • 30
    • 0032926818 scopus 로고    scopus 로고
    • Antiseptics and disinfectants: Activity, action, and resistance
    • McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev 1999;12:147-179 (Pubitemid 29055958)
    • (1999) Clinical Microbiology Reviews , vol.12 , Issue.1 , pp. 147-179
    • Mcdonnell, G.1    Russell, A.D.2
  • 31
    • 34247869622 scopus 로고    scopus 로고
    • Antimicrobial efficacy of gatifloxacin and moxifloxacin with and without benzalkonium chloride compared with ciprofloxacin and levofloxacin against methicillin-resistant Staphylococcus aureus
    • Blondeau JM, Borsos S, Hesje CK. Antimicrobial efficacy of gatifloxacin and moxifloxacin with and without benzalkonium chloride compared with ciprofloxacin and levofloxacin against methicillin-resistant Staphylococcus aureus. J Chemother 2007;19:146-151 (Pubitemid 46697733)
    • (2007) Journal of Chemotherapy , vol.19 , Issue.2 , pp. 146-151
    • Blondeau, J.M.1    Borsos, S.2    Hesje, C.K.3
  • 32
    • 67749108274 scopus 로고    scopus 로고
    • Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria
    • Haas W, Pillar CM, Zurenko GE, et al. Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 2009;53:3552-3560
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3552-3560
    • Haas, W.1    Pillar, C.M.2    Zurenko, G.E.3
  • 34
    • 70349390881 scopus 로고    scopus 로고
    • Bactericidal activity of besifloxacin and other ophthalmic antibacterials against recent ocular isolates
    • e-abstract 2675
    • Haas W, Brunner LS, Pillar C, Morris TW. Bactericidal activity of besifloxacin and other ophthalmic antibacterials against recent ocular isolates. Invest Ophthalmol Vis Sci 2009;50:e-abstract 2675
    • (2009) Invest Ophthalmol Vis Sci , vol.50
    • Haas, W.1    Brunner, L.S.2    Pillar, C.3    Morris, T.W.4
  • 35
    • 70349401910 scopus 로고    scopus 로고
    • Nonclinical ocular and systemic pharmacokinetics of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use
    • e-abstract 4273
    • Proksch J, Driot J-Y, Ward KW. Nonclinical ocular and systemic pharmacokinetics of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use. Invest Ophthalmol Vis Sci 2007;48:e-abstract 4273
    • (2007) Invest Ophthalmol Vis Sci , vol.48
    • Proksch, J.1    Driot, J.-Y.2    Ward, K.W.3
  • 36
    • 68549092580 scopus 로고    scopus 로고
    • Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans
    • Proksch JW, Granvil CP, Siou-mermet R, et al. Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans. J Ocul Pharmacol Ther 2009;25:335-344
    • (2009) J Ocul Pharmacol Ther , vol.25 , pp. 335-344
    • Proksch, J.W.1    Granvil, C.P.2    Siou-mermet, R.3
  • 37
    • 3342984904 scopus 로고    scopus 로고
    • In vitro activities of mutant prevention concentration-targeted concentrations of fluoroquinolones against Staphylococcus aureus in a pharmacodynamic model
    • Allen GP, Kaatz GW, Rybak MJ. In vitro activities of mutant prevention concentration-targeted concentrations of fluoroquinolones against Staphylococcus aureus in a pharmacodynamic model. Int J Antimicrob Agents 2004;24:150-160
    • (2004) Int J Antimicrob Agents , vol.24 , pp. 150-160
    • Allen, G.P.1    Kaatz, G.W.2    Rybak, M.J.3
  • 38
    • 3343024520 scopus 로고    scopus 로고
    • Comparison of minimal inhibitory and mutant prevention drug concentrations of 4 fluoroquinolones against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus
    • DOI 10.1016/j.ijantimicag.2004.02.021, PII S092485790400161X
    • Metzler K, Hansen GM, Hedlin P, et al. Comparison of minimal inhibitory and mutant prevention drug concentrations of 4 fluoroquinolones against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus. Int J Antimicrob Agents 2004;24:161-167 (Pubitemid 38993695)
    • (2004) International Journal of Antimicrobial Agents , vol.24 , Issue.2 , pp. 161-167
    • Metzler, K.1    Hansen, G.M.2    Hedlin, P.3    Harding, E.4    Drlica, K.5    Blondeau, J.M.6
  • 40
    • 70349408309 scopus 로고    scopus 로고
    • Besifloxacin, moxifloxacin, and gatifloxacin ocular tissue AUC/MIC ratios for fluoroquinolone-resistant organisms
    • e-abstract 2673
    • Proksch JW, Chappa AK, Haas W, Morris TW. Besifloxacin, moxifloxacin, and gatifloxacin ocular tissue AUC/MIC ratios for fluoroquinolone-resistant organisms. Invest Ophthalmol Vis Sci 2009;50:e-abstract 2673
    • (2009) Invest Ophthalmol Vis Sci , vol.50
    • Proksch, J.W.1    Chappa, A.K.2    Haas, W.3    Morris, T.W.4
  • 41
    • 67649400450 scopus 로고    scopus 로고
    • Phase III efficacy and safety study of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis
    • Tepedino ME, Heller WH, Usner DW, et al. Phase III efficacy and safety study of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis. Curr Med Res Opin 2009;25:1159-1169
    • (2009) Curr Med Res Opin , vol.25 , pp. 1159-1169
    • Tepedino, M.E.1    Heller, W.H.2    Usner, D.W.3
  • 42
    • 64849100973 scopus 로고    scopus 로고
    • Besifloxacin ophthalmic suspension 0.6% in patients with bacterial conjunctivitis: A multicenter, prospective, randomized, double-masked, vehicle-controlled, 5-day efficacy and safety study
    • Karpecki P, DePaolis M, Hunter JA, et al. Besifloxacin ophthalmic suspension 0.6% in patients with bacterial conjunctivitis: a multicenter, prospective, randomized, double-masked, vehicle-controlled, 5-day efficacy and safety study. Clin Ther 2009;31:514-526
    • (2009) Clin Ther , vol.31 , pp. 514-526
    • Karpecki, P.1    Depaolis, M.2    Hunter, J.A.3
  • 43
    • 69349091130 scopus 로고    scopus 로고
    • Efficacy and safety of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5% for treating bacterial conjunctivitis
    • Epub 2009 July 28
    • McDonald MB, Protzko EE, Brunner LS, et al. Efficacy and safety of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5% for treating bacterial conjunctivitis. Ophthalmology 2009. [Epub 2009 July 28]
    • (2009) Ophthalmology
    • McDonald, M.B.1    Protzko, E.E.2    Brunner, L.S.3
  • 44
    • 0026052336 scopus 로고
    • Antibacterial effectiveness of ciprofloxacin 0.3% ophthalmic solution in the treatment of bacterial conjunctivitis
    • Leibowitz HM. Antibacterial effectiveness of ciprofloxacin 0.3% ophthalmic solution in the treatment of bacterial conjunctivitis. Am J Ophthalmol 1991;112(Suppl 4):29-33S
    • (1991) Am J Ophthalmol , vol.112 , Issue.SUPPL. 4
    • Leibowitz, H.M.1
  • 45
    • 70349381314 scopus 로고    scopus 로고
    • Clinical efficacy of besifloxacin ophthalmic suspension; integrated microbiological analysis of 3 trials for topical treatment of bacterial conjunctivitis
    • e-abstract 5945
    • Morris TW, Hass W, Brunner LS, et al. Clinical efficacy of besifloxacin ophthalmic suspension; integrated microbiological analysis of 3 trials for topical treatment of bacterial conjunctivitis. Invest Ophthalmol Vis Sci 2009;50:e-abstract 5945
    • (2009) Invest Ophthalmol Vis Sci , vol.50
    • Morris, T.W.1    Hass, W.2    Brunner, L.S.3
  • 47
    • 70349389182 scopus 로고    scopus 로고
    • Besifloxacin ophthalmic suspension 0.6% is safe and well tolerated in the treatment of bacterial conjunctivitis
    • e-abstract 2674
    • Paterno MR, Comstock TL, Lynch JA, Usner DW. Besifloxacin ophthalmic suspension 0.6% is safe and well tolerated in the treatment of bacterial conjunctivitis. Invest Ophthalmol Vis Sci 2009;50:e-abstract 2674
    • (2009) Invest Ophthalmol Vis Sci , vol.50
    • Paterno, M.R.1    Comstock, T.L.2    Lynch, J.A.3    Usner, D.W.4
  • 49
    • 77951912170 scopus 로고    scopus 로고
    • Rochester, NY: Bausch & Lomb, Inc.
    • Besivance [package insert]. Rochester, NY: Bausch & Lomb, Inc.
    • Besivance [Package Insert]


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