Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes

Clinical Science

Volumn 117, Issue 6, 2009, Pages 229-236

  Mahal, Sharleet ^a   Strain, W David ^a   Martinez Perez, M Elena ^b   Thom, Simon A M ^a   Chaturvedi, Nish ^a   Hughes, Alan D ^a  

^a Faculty of Medicine   (United Kingdom)

^b Ciudad Universitaria   (Mexico)

Author keywords

Arteriole; Blood pressure; Diabetes; Ethnicity; Microvasculature; Retina

Indexed keywords

GLUCOSE; INSULIN; LIPID;

ADULT; AFRICAN CARIBBEAN; AGED; ARTERY DIAMETER; ARTICLE; BLOOD PRESSURE MONITORING; CLINICAL ASSESSMENT; DISEASE DURATION; ETHNIC DIFFERENCE; ETHNIC GROUP; EUROPEAN; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RETINA BLOOD VESSEL; SYSTOLIC BLOOD PRESSURE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ARTERIOLES; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LONDON; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; RETINAL VESSELS; RISK FACTORS; VENULES;

EID: 70349389598     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080538     Document Type: Article

References (51)

1. Fong, D. S., Aiello, L., Gardner, T. W., King, G. L., Blankenship, G., Cavallerano, J. D., Ferris, III, F. L. and Klein, R. (2003) Diabetic retinopathy. Diabetes Care 26, 226-229
2. Bek, T. and Helgesen, A. (2001) The regional distribution of diabetic retinopathy lesions may reflect risk factors for progression of the disease. Acta Ophthalmol. Scand. 79, 501-505
3. Fong, D. S., Aiello, L., Gardner, T. W., King, G. L., Blankenship, G., Cavallerano, J. D., Ferris, III, F. L. and Klein, R. (2004) Retinopathy in diabetes. Diabetes Care 27 (Suppl. 1), S84-S87
4. Kohner, E. M. (1997) Diabetic retinopathy and high blood pressure: defining the risk. Am. J. Hypertens. 10, 181S-183S
5. UK Prospective Diabetes Study Group (1998) Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br. Med. J. 317, 703-713
6. Heagerty, A. M., Aalkjaer, C., Bund, S. J., Korsgaard, N. and Mulvany, M. J. (1993) Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 21, 391-397
7. Izzard, A. S., Rizzoni, D., Agabiti-Rosei, E. and Heagerty, A. M. (2005) Small artery structure and hypertension: adaptive changes and target organ damage. J. Hypertens. 23, 247-250
8. Folkow, B. (1982) Physiological aspects of primary hypertension. Physiol. Rev. 62, 347-504
9. James, M. A., Tullett, J., Hemsley, A. G. and Shore, A. C. (2006) Effects of aging and hypertension on the microcirculation. Hypertension 47, 968-974
10. Porta, M., Grosso, A. and Veglio, F. (2005) Hypertensive retinopathy: there's more than meets the eye. J. Hypertens. 23, 683-696
11. Stanton, A. V., Mullaney, P., Mee, F., O'Brien, E. T. and O'Malley, K. (1995) A method of quantifying retinal microvascular alterations associated with blood pressure and age. J. Hypertens. 13, 41-48
12. Wong, T. Y., Wang, J. J., Rochtchina, E., Klein, R. and Mitchell, P. (2004) Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study. Am. J. Ophthalmol. 137, 1050-1055
13. Hughes, A. D., Martinez-Perez, E., Jabbar, A. S., Hassan, A., Witt, N.W., Mistry, P. D., Chapman, N., Stanton, A. V., Beevers, G., Pedrinelli, R. et al. (2006) Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J. Hypertens. 24, 889-894
14. Wiernsperger, N. F. (2001) In defense of microvascular constriction in diabetes. Clin. Hemorheol. Microcirc. 25, 55-62
15. Keen, H. (2000) Therapeutic objectives and their practical achievement in type 2 diabetes. J. Diabetes Complications 14, 180-184
16. Chaturvedi, N., McKeigue, P. M. and Marmot, M. G. (1994) Relationship of glucose intolerance to coronary risk in Afro-Caribbeans compared with Europeans. Diabetologia 37, 765-772
17. Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H. M. and Byrd-Holt, D. D. (1998) Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 21, 518-524
18. Harris, M. I., Klein, R., Cowie, C. C., Rowland, M. and Byrd-Holt, D. D. (1998) Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes? A U.S. population study. Diabetes Care 21, 1230-1235
19. Klein, R., Sharrett, A. R., Klein, B. E., Moss, S. E., Folsom, A. R., Wong, T. Y., Brancati, F. L., Hubbard, L. D. and Couper, D. (2002) The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes: the atherosclerosis risk in communities study. Ophthalmology 109, 1225-1234
20. McDonough, J. R., Garrison, G. E. and Hames, C. G. (1964) Blood pressure and hypertensive disease among Negroes and whites. Ann. Intern. Med. 61 (Suppl. 6), 208-228
21. Schneckloth, R. E., Stuart, K. L. and Moore, F. E. (1962) Arterial pressure and hypertensive disease in a West Indian Negro population. Report of a survey in St Kitts, West Indies. Am. Heart J. 63, 607-628
22. Wong, T. Y., Klein, R., Islam, F. M., Cotch, M. F., Folsom, A. R., Klein, B. E., Sharrett, A. R. and Shea, S. (2006) Diabetic retinopathy in a multi-ethnic cohort in the United States. Am. J. Ophthalmol. 141, 446-455
23. Sharp, P. S., Chaturvedi, N., Wormald, R., McKeigue, P. M., Marmot, M. G. and Young, S. M. (1995) Hypertensive retinopathy in Afro-Caribbeans and Europeans. Prevalence and risk factor relationships. Hypertension 25, 1322-1325
24. Wong, T. Y., Klein, R., Duncan, B. B., Nieto, F. J., Klein, B. E., Couper, D. J., Hubbard, L. D. and Sharrett, A. R. (2003) Racial differences in the prevalence of hypertensive retinopathy. Hypertension 41, 1086-1091
25. Strain, W. D., Chaturvedi, N., Nihoyannopoulos, P., Bulpitt, C. J., Rajkumar, C. and Shore, A. C. (2005) Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans. Diabetologia 48, 2269-2277
26. Strain, W. D., Chaturvedi, N. and Shore, A. (2005) Ethnic differences in microvascular structure and function. J. Hypertens. 23, 1434-1435
27. Strain, W. D., Chaturvedi, N., Leggetter, S., Nihoyannopoulos, P., Rajkumar, C., Bulpitt, C. J. and Shore, A. C. (2005) Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage. J. Hypertens. 23, 133-140
28. Chaturvedi, N. and McKeigue, P. M. (1994) Methods for epidemiological surveys of ethnic minority groups. J. Epidemiol. Community Health 48, 107-111
29. Martinez-Perez, M. E., Hughes, A. D., Stanton, A. V., Thom, S. A., Chapman, N., Bharath, A. A. and Parker, K. H. (2002) Retinal vascular tree morphology: a semi-automatic quantification. IEEE Trans. Biomed. Eng. 49, 912-917
30. Martinez-Perez, M. E. (2001) Computer Analysis of the Geometry of the Retinal Vasculature, Ph.D, Thesis, Imperial College London, London, U.K.
31. Hubbard, L. D., Brothers, R. J., King, W. N., Clegg, L. X., Klein, R., Cooper, L. S., Sharrett, A. R., Davis, M. D. and Cai, J. (1999) Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 106, 2269-2280
32. Wong, T. Y., Knudtson, M. D., Klein, R., Klein, B. E., Meuer, S. M. and Hubbard, L. D. (2004) Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 111, 1183-1190
33. King, L. A., Stanton, A. V., Sever, P. S., Thom, S. A. and Hughes, A. D. (1996) Arteriolar length-diameter (L:D) ratio: a geometric parameter of the retinal vasculature diagnostic of hypertension. J. Hum. Hypertens. 10, 417-418
34. Witt, N., Wong, T. Y., Hughes, A. D., Chaturvedi, N., Klein, B. E., Evans, R., McNamara, M., Thom, S. A. and Klein, R. (2006) Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension 47, 975-981
35. Pose-Reino, A., Gomez-Ulla, F., Hayik, B., Rodriguez-Fernandez, M., Carreira-Nouche, M. J., Mosquera-Gonzalez, A., Gonzalez-Penedo, M. and Gude, F. (2005) Computerized measurement of retinal blood vessel calibre: description, validation and use to determine the influence of ageing and hypertension. J. Hypertens. 23, 843-850
36. Hemminki, V., Kahonen, M., Tuomisto, M. T., Turjanmaa, V. and Uusitalo, H. (2007) Determination of retinal blood vessel diameters and arteriovenous ratios in systemic hypertension: comparison of different calculation formulae. Graefes Arch. Clin. Exp. Ophthalmol. 245, 8-17
37. Stanton, A. V., Wasan, B., Cerutti, A., Ford, S., Marsh, R., Sever, P. P., Thom, S. A. and Hughes, A. D. (1995) Vascular network changes in the retina with age and hypertension. J. Hypertens. 13, 1724-1728
38. Bland, J. M. and Altman, D. G. (1999) Measuring agreement in method comparison studies. Stat. Methods Med. Res. 8, 135-160
39. Lin, L. I. (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45, 255-268
40. Chapman, N., Witt, N., Gao, X., Bharath, A. A., Stanton, A. V., Thom, S. A. and Hughes, A. D. (2001) Computer algorithms for the automated measurement of retinal arteriolar diameters. Br. J. Ophthalmol. 85, 74-79
41. Klein, R., Klein, B. E., Moss, S. E.,Wong, T. Y., Hubbard, L., Cruickshanks, K. J. and Palta, M. (2003) Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology 110, 2118-2125
42. Nguyen, T. T.,Wang, J. J., Sharrett, A. R., Islam, F. M., Klein, R., Klein, B. E., Cotch, M. F. and Wong, T. Y. (2008) Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care 31, 544-549
43. Scheie, H. G. (1953) Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. Arch. Ophthalmol. 49, 117-138
44. Wong, T. Y., Klein, R., Klein, B. E., Tielsch, J. M., Hubbard, L. and Nieto, F. J. (2001) Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Surv. Ophthalmol. 46, 59-80
45. Wong, T. Y., Hubbard, L. D., Klein, R., Marino, E. K., Kronmal, R., Sharrett, A. R., Siscovick, D. S., Burke, G. and Tielsch, J. M. (2002) Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study. Br. J. Ophthalmol. 86, 1007-1013
46. Wang, J. J., Mitchell, P., Leung, H., Rochtchina, E., Wong, T. Y. and Klein, R. (2003) Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension 42, 534-541
47. Wong, T. Y., Klein, R., Sharrett, A. R., Manolio, T. A., Hubbard, L. D., Marino, E. K., Kuller, L., Burke, G., Tracy, R. P., Polak, J. F. et al. (2003) The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study. Ophthalmology 110, 658-666
48. Tillin, T., Evans, R. M., Witt, N. W., Sharp, P. S., McKeigue, P. M., Chaturvedi, N. and Hughes, A. D. (2008) Ethnic differences in retinal microvascular structure. Diabetologia 51, 1719-1722
49. Rizzoni, D., Porteri, E., Guelfi, D., Muiesan, M. L., Valentini, U., Cimino, A., Girelli, A., Rodella, L., Bianchi, R., Sleiman, I. and Rosei, E. A. (2001) Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus. Circulation 103, 1238-1244
50. Schofield, I., Malik, R., Izzard, A., Austin, C. and Heagerty, A. (2002) Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia. Circulation 106, 3037-3043
51. Rochtchina, E., Wang, J. J., Taylor, B., Wong, T. Y. and Mitchell, P. (2008) Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation? The Sydney Childhood Eye Study. Invest. Ophthalmol. Visual Sci. 49, 1362-1366