Structure-reactivity relationships for β-galactosidase (Escherichia coli, lac Z). 4. Mechanism for reaction of nucleophiles with the galactosyl- enzyme intermediates of E461G and E461Q β-galactosidases

Biochemistry

Volumn 35, Issue 38, 1996, Pages 12387-12401

  Richard, John P ^a   Huber, Reuben E ^b   Heo, Christine ^a   Amyes, Tina L ^a   Lin, Sue ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BACTERIAL ENZYME; BETA GALACTOSIDASE; BUTYRIC ACID; CYANIDE; GALACTOSE; MUTANT PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ACETATES; AZIDES; BETA-GALACTOSIDASE; ESCHERICHIA COLI; FORMATES; GALACTOSE; GALACTOSIDES; KINETICS; MODELS, CHEMICAL; NITROPHENYLGALACTOSIDES; POINT MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0029844698     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961029b     Document Type: Article

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