Heme oxygenase-1 induced by aprotinin inhibits vascular smooth muscle cell proliferation through cell cycle arrest in hypertensive rats

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 4, 2009, Pages 309-313

  Hyoung, Chul Choi ^a   Kwang, Youn Lee ^a   Dong, Hyup Lee ^a   Young, Jin Kang ^a  

^a Yeungnam University College of Medicine   (South Korea)

Author keywords

Aprotinin; Cell cycle arrest; Heme oxygenase 1; Hypertension; Proliferation

Indexed keywords

APROTININ; CYCLIN D; HEME OXYGENASE 1; PROTEIN P21; PROTOPORPHYRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; GENETIC TRANSFECTION; MALE; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; VASCULAR SMOOTH MUSCLE;

EID: 70349378682     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.4.309     Document Type: Article

References (24)

1. Bidstrup BP, Royston D, Sapsford RN, Taylor KM. Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). J Thorac Cardiovasc Surg 97: 364-372, 1989.
2. Chang T, Wu L, Wang R. Inhibition of vascular smooth muscle cell proliferation by chronic hemin treatment. Am J Physiol Heart Circ Physiol 295: H999-H1007, 2008.
3. Dong Y, Chi SL, Borowsky AD, Fan Y, Weiss RH. Cytosolic p21Waf1/Cip1 increases cell cycle transit in vascular smooth muscle cells. Cell Signal 16: 263-269, 2004.
4. Duckers HJ, Boehm M, True al., Yet SF, San H, Park JL, Clinton Webb R, Lee ME, Nabel GJ, Nabel EG. Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med 7: 693-698, 2001.
5. Dulic V, Lees E, Reed SI. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257: 1958-1961, 1992.
6. Englberger L, Kipfer B, Berdat PA, Nydegger UE, Carrel TP. Aprotinin in coronary operation with cardiopulmonary bypass: does "low-dose" aprotinin inhibit the inflammatory response? Ann Thorac Surg 73: 1897-1904, 2002.
7. Hunter T. Braking the cycle. Cell 75: 839-841, 1993.
8. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38: 581-587, 2001.
9. Jeon EM, Choi HC, Lee KY, Chang KC, Kang YJ. Hemin inhibits hypertensive rat vascular smooth muscle cell proliferation through regulation of cyclin D and p21. Arch Pharm Res 32: 375-382, 2009.
10. Lee DH, Choi HC, Lee KY, Kang YJ. Aprotinin inhibits vascular smooth muscle cell inflammation and proliferation via induction of HO-1. Korean J Physiol Pharmacol 13: 123-130, 2009.
11. Levy JH. Pharmacologic preservation of the hemostatic system during cardiac surgery. Ann Thorac Surg 72: S1814-1820, 2001.
12. Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354: 353-365, 2006.
13. McEvoy MD, Taylor AG, Zavadzkas JA, Mains IM, Ford RL, Stroud RE, Jeffords LB, Beck CU, Reeves ST, Spinale FG. Aprotinin exerts differential and dose-dependent effects on myocardial contractility, oxidative stress, and cytokine release after ischemia-reperfusion. Ann Thorac Surg 86: 568-575, 2008.
14. Ndisang JF, Wu L, Zhao W, Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101: 3893-3900, 2003.
15. Ndisang JF, Zhao W, Wang R. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40: 315-321, 2002.
16. Ngaage DL, Cale AR, Cowen ME, Griffin S, Guvendik L. Aprotinin in primary cardiac surgery: operative outcome of propensity score-matched study. Ann Thorac Surg 86: 1195-1202, 2008.
17. Peyton KJ, Reyna SV, Chapman GB, Ensenat D, Liu XM, Wang H, Schafer AI, Durante W. Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood 99: 4443-4448, 2002.
18. Resink TJ, Scott-Burden T, Baur U, Bühler FR. Increased proliferation fate and phosphoinositide turnover in cultured smooth muscle cells from spontaneously hypertensive rats. J Hypertens Suppl 5: S145-148, 1987.
19. Sherr CJ. Cancer cell cycles. Science 274: 1672-1677, 1996.
20. Sherr CJ. Mammalian G1 cyclins. Cell 73: 1059-1065, 1993.
21. Taillé C, Ahmolki A, Benhamed M, Zedda C, Mégret J, Berger P, Leséche G, Fadel E, Yamaguchi T, Marthan R, Aubier M, Boczkowski J. Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. J Biol Chem 278: 27160-27168, 2003.
22. Tanner FC, Greutert H, Barandier C, Frischknecht K, Lüscher TF. Different cell cycle regulation of vascular smooth muscle in genetic hypertension. Hypertension 42: 184-188, 2003.
23. Wang R, Shamloul R, Wang X, Meng Q, Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension 48: 685-692, 2006.
24. Westaby S. Aprotinin in perspective. Ann Thorac Surg 55: 1033-1041, 1993.