-
2
-
-
0034090264
-
Hepatocellular carcinoma
-
Okuda K: Hepatocellular carcinoma. J Hepatol 32: 225-237, 2000.
-
(2000)
J Hepatol
, vol.32
, pp. 225-237
-
-
Okuda, K.1
-
3
-
-
0345643514
-
Regulation of matrix metalloproteinase expression in tumor invasion
-
Westermarck J and Kahari VM: Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13: 781-792, 1999.
-
(1999)
FASEB J
, vol.13
, pp. 781-792
-
-
Westermarck, J.1
Kahari, V.M.2
-
4
-
-
0031050890
-
Differences in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinoma
-
Okazaki I, Wada N, Nakano M, Saito A, Takasaki K, Doi M, Kameyama K, Otani Y, Kubochi K, Niioka M, Watanabe T and Maruyama K: Differences in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinoma. Hepatology 25: 580-584, 1997.
-
(1997)
Hepatology
, vol.25
, pp. 580-584
-
-
Okazaki, I.1
Wada, N.2
Nakano, M.3
Saito, A.4
Takasaki, K.5
Doi, M.6
Kameyama, K.7
Otani, Y.8
Kubochi, K.9
Niioka, M.10
Watanabe, T.11
Maruyama, K.12
-
5
-
-
0030970553
-
Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma
-
Yamamoto H, Itoh F, Adachi Y, Sakamoto H, Adachi M, Hinoda Y and Imai K: Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma. Gastroenterology 112: 1290-1296, 1997.
-
(1997)
Gastroenterology
, vol.112
, pp. 1290-1296
-
-
Yamamoto, H.1
Itoh, F.2
Adachi, Y.3
Sakamoto, H.4
Adachi, M.5
Hinoda, Y.6
Imai, K.7
-
6
-
-
0029741786
-
Overexpression of matrix metalloproteinase 9 gene in heopatocellular carcinoma with invasive potential
-
Arii S, Mise M, Harada T, Furutani M, Ishigami S, Niwano M, Mizumoto M, Fukumoto M and Imamura M: Overexpression of matrix metalloproteinase 9 gene in heopatocellular carcinoma with invasive potential. Hepatology 24: 316-322, 1996.
-
(1996)
Hepatology
, vol.24
, pp. 316-322
-
-
Arii, S.1
Mise, M.2
Harada, T.3
Furutani, M.4
Ishigami, S.5
Niwano, M.6
Mizumoto, M.7
Fukumoto, M.8
Imamura, M.9
-
7
-
-
10544236907
-
Cellular distribution of 92-kD type IV collagenase/gelatinase B in human hepatocellular carcinoma
-
Ashida K, Nakatsukasa H, Higashi T, Ohguchi S, Hino N, Nouso K, Urabe Y, Yoshida K, Kinugasa N and Tsujii T: Cellular distribution of 92-kD type IV collagenase/gelatinase B in human hepatocellular carcinoma. Am J Pathol 149: 1803-1811, 1996.
-
(1996)
Am J Pathol
, vol.149
, pp. 1803-1811
-
-
Ashida, K.1
Nakatsukasa, H.2
Higashi, T.3
Ohguchi, S.4
Hino, N.5
Nouso, K.6
Urabe, Y.7
Yoshida, K.8
Kinugasa, N.9
Tsujii, T.10
-
8
-
-
0032006647
-
Membrane-type matrix metalloproteinase-1 (MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas
-
Harada T, Arii S, Mise M, Imamura T, Higashitsuji H, Furutani M, Niwano M, Ishigami S, Fukumoto M, Seiki M, Sato H and Imamura M: Membrane-type matrix metalloproteinase-1 (MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas. J Hepatol 28: 231-239, 1998.
-
(1998)
J Hepatol
, vol.28
, pp. 231-239
-
-
Harada, T.1
Arii, S.2
Mise, M.3
Imamura, T.4
Higashitsuji, H.5
Furutani, M.6
Niwano, M.7
Ishigami, S.8
Fukumoto, M.9
Seiki, M.10
Sato, H.11
Imamura, M.12
-
9
-
-
0033709612
-
Involvement of the Ets-1 gene in overexpression matrilysin in human hepatocellular carcinoma
-
Ozaki I, Mizuta T, Zhao G, Yotsumoto H, Hara T, Kajihara S, Hisatomi A, Sakai T and Yamamoto K: Involvement of the Ets-1 gene in overexpression matrilysin in human hepatocellular carcinoma. Cancer Res 60: 6519-6525, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 6519-6525
-
-
Ozaki, I.1
Mizuta, T.2
Zhao, G.3
Yotsumoto, H.4
Hara, T.5
Kajihara, S.6
Hisatomi, A.7
Sakai, T.8
Yamamoto, K.9
-
10
-
-
0346895108
-
Induction of matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1
-
Ozaki I, Mizuta T, Zhao G, Zhang H, Yoshimura T, Kawazoe S, Eguchi Y, Yasutake T, Hisatomi A, Sakai T and Yamamoto K: Induction of matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1. Hepatol Res 27: 288-300, 2003.
-
(2003)
Hepatol Res
, vol.27
, pp. 288-300
-
-
Ozaki, I.1
Mizuta, T.2
Zhao, G.3
Zhang, H.4
Yoshimura, T.5
Kawazoe, S.6
Eguchi, Y.7
Yasutake, T.8
Hisatomi, A.9
Sakai, T.10
Yamamoto, K.11
-
11
-
-
0033559305
-
Vitamin K-dependent biosynthesis of γ-carboxylglutamic acid
-
Furie B, Bouchard BA and Furie BC: Vitamin K-dependent biosynthesis of γ-carboxylglutamic acid. Blood 93: 1798-1808, 1999.
-
(1999)
Blood
, vol.93
, pp. 1798-1808
-
-
Furie, B.1
Bouchard, B.A.2
Furie, B.C.3
-
12
-
-
0031263668
-
The roles of vitamin D and vitamin K in bone health and osteoporosis prevention
-
Shearer MJ: The roles of vitamin D and vitamin K in bone health and osteoporosis prevention. Proc Nutr Soc 56: 915-937, 1997.
-
(1997)
Proc Nutr Soc
, vol.56
, pp. 915-937
-
-
Shearer, M.J.1
-
13
-
-
0028618303
-
Novel role of vitamin K2: A potent inducer of differentiation of various human myeloid leukemia cell lines
-
Sakai I, Hashimoto S, Yoda M, Hida T, Ohsawa S, Nakajo S, and Nakaya K: Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell lines. Biochem Biophys Res Commun 205: 1305-1310, 1994.
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 1305-1310
-
-
Sakai, I.1
Hashimoto, S.2
Yoda, M.3
Hida, T.4
Ohsawa, S.5
Nakajo, S.6
Nakaya, K.7
-
14
-
-
0027516607
-
Comparison of antitumor activity of vitamins K1, K2, K3 on human tumor cells by two (MTT and SRB) assays
-
Wu FYH, Liao WC and Chang HM: Comparison of antitumor activity of vitamins K1, K2, K3 on human tumor cells by two (MTT and SRB) assays. Life Sci 52: 1797-1804, 1993.
-
(1993)
Life Sci
, vol.52
, pp. 1797-1804
-
-
Wu, F.Y.H.1
Liao, W.C.2
Chang, H.M.3
-
15
-
-
0028868944
-
Growth inhibition of hepatoma cells induced by vitamin K and its analog
-
Nishikawa Y, Carr BI, Wang M, Kars S, Finn F, Dowd P, Zheng ZB, Kerns J and Naganathan S: Growth inhibition of hepatoma cells induced by vitamin K and its analog. J Biol Chem 270: 28304-28310, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 28304-28310
-
-
Nishikawa, Y.1
Carr, B.I.2
Wang, M.3
Kars, S.4
Finn, F.5
Dowd, P.6
Zheng, Z.B.7
Kerns, J.8
Naganathan, S.9
-
16
-
-
32544446614
-
The effect of menatetrenone, a vitamin K2 analog, on recurrence and survival in patients with hepatocellular carcinoma after curative treatment: A pilot study
-
Mizuta T, Ozaki I, Eguchi Y, Yasutake T, Kawazoe S, Fujimoto K and Yamamoto K: The effect of menatetrenone, a vitamin K2 analog, on recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer 106: 867-872, 2006.
-
(2006)
Cancer
, vol.106
, pp. 867-872
-
-
Mizuta, T.1
Ozaki, I.2
Eguchi, Y.3
Yasutake, T.4
Kawazoe, S.5
Fujimoto, K.6
Yamamoto, K.7
-
17
-
-
3142708765
-
Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver
-
Habu D, Shiomi S, Tamori A, Takeda T, Tanaka T, Kubo S and Nishiguchi S: Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. JAMA 292: 358-367, 2004.
-
(2004)
JAMA
, vol.292
, pp. 358-367
-
-
Habu, D.1
Shiomi, S.2
Tamori, A.3
Takeda, T.4
Tanaka, T.5
Kubo, S.6
Nishiguchi, S.7
-
18
-
-
3042697863
-
Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation
-
Otsuka M, Kato N, Shao RX, Hoshida Y, Ijichi H, Koike Y, Taniguchi H, Moriyama M, Shiratori Y, Kawabe T and Omata M: Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology 40: 243-251, 2004.
-
(2004)
Hepatology
, vol.40
, pp. 243-251
-
-
Otsuka, M.1
Kato, N.2
Shao, R.X.3
Hoshida, Y.4
Ijichi, H.5
Koike, Y.6
Taniguchi, H.7
Moriyama, M.8
Shiratori, Y.9
Kawabe, T.10
Omata, M.11
-
19
-
-
20144389070
-
Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression
-
Yoshiji H, Kuriyama S, Noguchi R, Yoshii J, Ikenaka Y, Yanase K, Namisaki T, Kitade M, Yamazaki M, Masaki T and Fukui H: Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression. J Hepatol 42: 687-693, 2005.
-
(2005)
J Hepatol
, vol.42
, pp. 687-693
-
-
Yoshiji, H.1
Kuriyama, S.2
Noguchi, R.3
Yoshii, J.4
Ikenaka, Y.5
Yanase, K.6
Namisaki, T.7
Kitade, M.8
Yamazaki, M.9
Masaki, T.10
Fukui, H.11
-
20
-
-
34249314048
-
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: In vitro and in vivo experiments
-
Sakakima Y, Hayakawa A, Nagasaka T and Nakao A: Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments. J Hepatol 47: 83-92, 2007.
-
(2007)
J Hepatol
, vol.47
, pp. 83-92
-
-
Sakakima, Y.1
Hayakawa, A.2
Nagasaka, T.3
Nakao, A.4
-
21
-
-
0031570725
-
Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels
-
Leber TM and Balkwill FR: Zymography: a single-step staining method for quantitation of proteolytic activity on substrate gels. Anal Biochem 249: 24-28, 1997.
-
(1997)
Anal Biochem
, vol.249
, pp. 24-28
-
-
Leber, T.M.1
Balkwill, F.R.2
-
22
-
-
0027076118
-
Effect of phorbol ester and cytokines on matrix metalloproteinases and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines
-
Mckay AR, Ballin M, Pelina MD, Farina AR, Nason AM, Hartzler JL and Thorgeirsson UP: Effect of phorbol ester and cytokines on matrix metalloproteinases and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines. Invasion Metastasis 18: 168-184, 1992.
-
(1992)
Invasion Metastasis
, vol.18
, pp. 168-184
-
-
Mckay, A.R.1
Ballin, M.2
Pelina, M.D.3
Farina, A.R.4
Nason, A.M.5
Hartzler, J.L.6
Thorgeirsson, U.P.7
-
23
-
-
0029789182
-
Protein kinase C isozymes differentially regulate promoters containing PEA3/12-O-tetradecanoyl-13-actate response element motifs
-
Reifel-Miller AE, Conarty DM, Valasek KM, Iversen PW, Burns DJ and Birch KA: Protein kinase C isozymes differentially regulate promoters containing PEA3/12-O-tetradecanoyl-13-actate response element motifs. J Biol Chem 271: 21666-21671, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 21666-21671
-
-
Reifel-Miller, A.E.1
Conarty, D.M.2
Valasek, K.M.3
Iversen, P.W.4
Burns, D.J.5
Birch, K.A.6
-
24
-
-
34247537075
-
Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor κB activation
-
Ozaki I, Zhang H, Mizuta T, Ide Y, Eguchi Y, Yasutake T, Sakamaki T, Pestell RG and Yamamoto K: Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor κB activation. Clin Cancer Res 13: 2236-2245, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2236-2245
-
-
Ozaki, I.1
Zhang, H.2
Mizuta, T.3
Ide, Y.4
Eguchi, Y.5
Yasutake, T.6
Sakamaki, T.7
Pestell, R.G.8
Yamamoto, K.9
-
25
-
-
0033571108
-
The anti-inflammatory sequiterpene lactone parthenoide inhibits NF-kappa B by tarteting the I kappa B kinase complex
-
Hehner SP, Hofmann TG, Droge W and Schmitz ML: The anti-inflammatory sequiterpene lactone parthenoide inhibits NF-kappa B by tarteting the I kappa B kinase complex. J Immunol 163: 5617-5623, 1999.
-
(1999)
J Immunol
, vol.163
, pp. 5617-5623
-
-
Hehner, S.P.1
Hofmann, T.G.2
Droge, W.3
Schmitz, M.L.4
-
26
-
-
0036888314
-
K vitamins, PTP antagonism, and cell growth arrest
-
Carr BI, Wang Z and Kar S: K vitamins, PTP antagonism, and cell growth arrest. J Cell Physiol 193: 263-274, 2002.
-
(2002)
J Cell Physiol
, vol.193
, pp. 263-274
-
-
Carr, B.I.1
Wang, Z.2
Kar, S.3
-
27
-
-
33644850413
-
Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cell line
-
Tokita H, Tsuchida A, Miyazawa K, Ohyashiki K, Katayanagi S, Sudo H, Enomoto M, Takagi Y and Aoki T: Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cell line. Int J Mol Med 17: 235-243, 2006.
-
(2006)
Int J Mol Med
, vol.17
, pp. 235-243
-
-
Tokita, H.1
Tsuchida, A.2
Miyazawa, K.3
Ohyashiki, K.4
Katayanagi, S.5
Sudo, H.6
Enomoto, M.7
Takagi, Y.8
Aoki, T.9
-
28
-
-
33744495081
-
The mechanisms of vitamin K2-induced apoptosis of myeloma cells
-
Tsukioka T, Miura Y, Otsuki T, Nishimura Y, Hyodoh F, Wada H and Sugihara T: The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 91: 613-619, 2006.
-
(2006)
Haematologica
, vol.91
, pp. 613-619
-
-
Tsukioka, T.1
Miura, Y.2
Otsuki, T.3
Nishimura, Y.4
Hyodoh, F.5
Wada, H.6
Sugihara, T.7
-
29
-
-
21644456378
-
Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines
-
Yokoyama T, Miyazawa K, Yoshida T and Ohyashiki K: Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. Int J Oncol 26: 33-40, 2005.
-
(2005)
Int J Oncol
, vol.26
, pp. 33-40
-
-
Yokoyama, T.1
Miyazawa, K.2
Yoshida, T.3
Ohyashiki, K.4
-
30
-
-
33747436183
-
Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells
-
Sibayama-Imazu T, Sonoda I, Sakairi S, Aiuchi T, Ann W, Nakajo S, Itabe H and Nakaya K: Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells. Apoptosis 11: 1535-1543, 2006.
-
(2006)
Apoptosis
, vol.11
, pp. 1535-1543
-
-
Sibayama-Imazu, T.1
Sonoda, I.2
Sakairi, S.3
Aiuchi, T.4
Ann, W.5
Nakajo, S.6
Itabe, H.7
Nakaya, K.8
-
31
-
-
0033595590
-
Nuclear factor κB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblast
-
Bond M, Baker AH and Newby AC: Nuclear factor κB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblast. Biochem Biophys Res Commun 264: 561-567, 1999.
-
(1999)
Biochem Biophys Res Commun
, vol.264
, pp. 561-567
-
-
Bond, M.1
Baker, A.H.2
Newby, A.C.3
-
32
-
-
0043172368
-
Stimulation of MMP-7(matrilysin) by Helicobacter pylori in human gastric epithelial cells: Role in epithelial cell migration
-
Wroblewski LE, Noble PJM, Pagliocca A, Pritchard DM, Hart A, Campbell F, Dodson AR, Dockray GJ and Varro A: Stimulation of MMP-7(matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J Cell Sci 116: 3017-3026, 2003.
-
(2003)
J Cell Sci
, vol.116
, pp. 3017-3026
-
-
Wroblewski, L.E.1
Noble, P.J.M.2
Pagliocca, A.3
Pritchard, D.M.4
Hart, A.5
Campbell, F.6
Dodson, A.R.7
Dockray, G.J.8
Varro, A.9
-
33
-
-
33846686308
-
Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells
-
Kanamori T, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Kojima S and Moriwaki H: Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells. Cancer Sci 98: 431-437, 2007.
-
(2007)
Cancer Sci
, vol.98
, pp. 431-437
-
-
Kanamori, T.1
Shimizu, M.2
Okuno, M.3
Matsushima-Nishiwaki, R.4
Tsurumi, H.5
Kojima, S.6
Moriwaki, H.7
-
34
-
-
0029032249
-
The regulation of AP-1 activity by mitogen-activated protein kinases
-
Karin M: The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270: 16483-16486, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 16483-16486
-
-
Karin, M.1
-
35
-
-
0028811653
-
Protein kinase C; structure, function and regulation
-
Newton AC: Protein kinase C; structure, function and regulation. J Biol Chem 270: 28495-28498, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 28495-28498
-
-
Newton, A.C.1
-
36
-
-
0142106971
-
Protein kinase C: A target for anticancer drugs?
-
Mackay HJ and Tweleves CJ: Protein kinase C: a target for anticancer drugs? Endocrine-Related Cancer 10: 389-396, 2003.
-
(2003)
Endocrine-Related Cancer
, vol.10
, pp. 389-396
-
-
Mackay, H.J.1
Tweleves, C.J.2
-
37
-
-
33747097252
-
Protein kinases and phosphatases as therapeutic targets in cancer
-
Ventura JJ and Nebreda AR: Protein kinases and phosphatases as therapeutic targets in cancer. Clin Trans Oncol 8: 153-160, 2006.
-
(2006)
Clin Trans Oncol
, vol.8
, pp. 153-160
-
-
Ventura, J.J.1
Nebreda, A.R.2
-
38
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R and Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 5: 835-844, 2006.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
39
-
-
0031027503
-
A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis
-
Saxena SP, Fan T, Li M and Israels ED: A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis. J Clin Invest 99: 602-607, 1997.
-
(1997)
J Clin Invest
, vol.99
, pp. 602-607
-
-
Saxena, S.P.1
Fan, T.2
Li, M.3
Israels, E.D.4
|