Control of the skin scarring response

Anais da Academia Brasileira de Ciencias

Volumn 81, Issue 3, 2009, Pages 623-629

  Ferreira, Lydia M ^a   Gragnani, Alfredo ^a   Furtado, Fabianne ^a   Hochman, Bernardo ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Fibroblasts; Keloid; Keratinocytes; Plastic surgery; Skin; Tissue engineering; Wound healing

Indexed keywords

EID: 70349308478     PISSN: 00013765     EISSN: 16782690     Source Type: Journal    
DOI: 10.1590/S0001-37652009000300024     Document Type: Article

References (75)

1. Allen JA, Armstrong JE and Roddie IC. 1973. The regional distribution of emotional sweating in man. J Physiol 235: 749-759.
2. Altun V, Hakvoort TE, van Zuijlen PP, van der Kwast TH and Prens EP. 2001. Nerve outgrowth and neuropeptide expression during the remodeling of human burn wound scars. A 7-month follow-up study of 22 patients. Burns 27(7): 717-722.
3. Barros J and Barros M. 1996. Cicatrizes hipertróficas y homeopatía. Gac Homeop Caracas 4(2): 73-78.
4. Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, Faulkner E, Gould C, Gemmen E and Dall T. 2006. The burden of skin diseases: 2004. A joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol 55: 490-500.
5. Bock O and Mrowietz U. 2002. Keloids. A fibroproliferative disorder of unknown etiology. Hautarzt 53(8): 515-523.
6. Bock O, Schmid-Ott G, Malewski P and Mrowietz U. 2006. Quality of life of patients with keloid and hypetrophic scarring. Arch Dermatol Res 297(10): 433-438.
7. Bombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA, Heimbach DM, Rivara FP and Honari S. 2003. What is the prevalence of hypertrophic scarring following burns? Burns 29(4): 299-302.
8. Campaner AB, Ferreira LM, Gragnani A, Bruder JM, Cusick JL and Morgan JR. 2006. Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring.J Invest Dermatol 126: 1168-1176.
9. Canary PCV, Fillippo R, Pinto LHP and Aidar S. 1990. Papel da radioterapia no tratamento de quelóides: análise retrospectiva de 267 casos. Rev Bras Cir 80(5): 291-295.
10. Clayman MA, Clayman SM and Mozingo DW. 2006. The use of collagen-glycosaminoglycan copolymer (Integra) for the repair of hypertrophic scars and keloids. J Burn Care Res 27: 404-409.
11. Crowe R, Parkhouse N, McGrouther D and Burnstock G. 1994. Neuropeptide-containing nerves in painful hypertrophic human scar tissue. Br J Dermatol 130: 444-452.
12. Davies K, Nduka C and Moir G. 2004. Nurse-led management of hypertrophic and keloid scars. Nurs Times 100(5): 40-44.
13. Dhabhar FS and McEwen BS. 1999. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci USA 96: 1059-1064.
14. Duarte IS, Gragnani A and Ferreira LM. 2004. Dimethyl sulfoxide and oxidative stress on cultures on culture of human keratinocytes. Can J Plast Surg 12: 13-16.
15. Esteves Jr I, Ferreira LM and Liebano RE. 2004. Peptídeo relacionado ao gene da calcitonina por iontoforese na viabilidade de retalho cutâneo randômico em ratos. Acta Cir Bras 19: 626-629.
16. Ferreira LM. 2004. Cirurgia plástica: uma abordagem antroposófica. Rev Soc Bras Plast 19: 37-40.
17. Finch PW, Cunha Gr, Rubin JS, Wong J and Ron D. 1995. Pattern of queratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development sugests a role in mediating morphogenetic mesenchymal-epithelial interactions. Dev Dyn 203: 223-240.
18. Gauthier Y. 1996. Stress and skin: experimental approach. Pathol Biol (Paris) 44: 882-887.
19. Glaser R, Kiecolt-Glaser JK, Marucha PT, MacCallum RC, Laskowski BF and Malarkey WB. 1999. Stress-related changes in proinflammatory cytokine production in wounds. Arch Gen Psychiatry 56: 450-456.
20. Gragnani A, Morgan JR and Ferreira LM. 2002. Differentiation and barrier formation of a cultured composite skin graft. J Burn Care Rehabil 23: 126-131.
21. GragnaniA, MorganJR andFerreira LM. 2004. Experimental model of cultured skin graft. Acta Cir Bras 19(Suppl 1): 4-10.
22. Gragnani A, Keira SM, Hochman B and Ferreira LM. 2007a. Cicatrização - Fibroplasia e fatores de crescimento. In: Schor N, Ferreira LM (Eds), Guia de Cirurgia Plástica, Barueri: Manole, São Paulo, SP, Brasil, p. 49-53.
23. Gragnani A, Sobral CS and Ferreira LM. 2007b. Thermolysin in human cultured keratinocyte isolation. Braz J Biol 67: 105-109.
24. Gragnani A, Ipolito MZ, Sobral CS, Brunialti MK, Salomão R and Ferreira LM. 2008. Flow cytometry of human primary epidermal and follicular keratinocytes. Eplasty 19: 8-14.
25. Grützkau A, Henz BM, Kirchhof L, Luger T and Artuc M. 2000. Alpha-Melanocyte stimulating hormone acts as a selective inducer of secretory functions in human mast cells. Biochem Biophys Res Commun 278: 14-19.
26. Hochman B and Ferreira LM. 2007. Quelóide. In: Schor N and Ferreira LM (Eds), Guia de Cirurgia Plástica, Barueri: Manole. São Paulo, SP, Brasil, Cirurgia Plástica, p. 65-74.
27. Hochman B, Ferreira LM, Vilas Bôas FC and Mariano M. 2004. Hamster (Mesocricetus auratus) cheek pouch as an experimental model to investigate hu man skin and keloid heterologous graft. Acta Cir Bras 19(Suppl 1): 79-88.
28. Hochman B, Vilas Bôas FC, Mariano M and Ferreira LM. 2005. Keloid heterograft in the hamster (Mesocricetus saturate) cheek pouch. Acta Cir Bras 20(3): 200-212.
29. Hochman B, Locali RF, Matsuoka PK and Ferreira LM. 2008a. Intralesional triamcinolone acetonide for keloid treatment: a systematic review. Aesthetic Plast Surg 32: 705-709.
30. Hochman B, Nahas FX, Sobral CS, Arias V, Locali RF, Juliano Y and Ferreira LM. 2008b. Nerve fibers: a possible role in keloid pathogenesis. Br J Dermatol 158: 651-652.
31. Ishizuka CK, Itamoto KY, Hochman B and Ferreira LM. 2007. Cicatriz hipertrófica. In: Schor N and Ferreira LM (Eds), Guia de Cirurgia Plástica, Barueri: Manole, São Paulo, SP, Brasil, p. 55-63.
32. Jafferany M. 2007. Psychodermatology: a guide to understanding common psychocutaneous disorders. Prim Care Companion J Clin Psychiatry 9(3): 203-213.
33. Keira SM, Ferreira LM, Gragnani A, Duarte IS and Barbosa J. 2004. Experimental model for collagen estimation in cell culture. Acta Cir Bras 19(Suppl 1): 17-22.
34. Kim LR, Whelpdale K, Zurowski M and Pomeranz B. 1998. Sympathetic denervation impairs epidermal healing in cutaneous wounds. Wound Rep Reg 6(3): 194-201.
35. Kimyai-Asadi A and Usman A. 2001. The role of psychological stress in skin disease. J Cutan Med Surg 5(2): 140-145.
36. Komarcevic A, Pejakov L and Komarcevic M. 2000. New views on the physiology of wound healing. Med Pregl 53(9-10): 479-483.
37. Kono M, Nagata H, Umemura S, Kawana S and Osamura RY. 2001. In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 15: 2297-2299.
38. Koo J and Lebwohl A. 2001. Psycho dermatology: the mind and skin connection. Am Fam Physician 64: 1873-1878.
39. KRAUSE K, SCHNITGER A, FIMMEL S, GLASS E AND Zouboulis CC. 2007. Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands. Horm Metab Res 39(2): 166-170.
40. Leigh IM, Lane EB and Watt FM. 1994. The Keratinocyte Handbook. Cambridge: University Press, 566 p.
41. Liang Z, Engrav LH, Muangman P, Muffley LA, Zhu KQ, Carrougher GJL, Underwood RA and Gibran NS. 2004. Nerve quantification in female red Duroc pig (FRDP) scar compared to human hypertrophic scar. Burns 30: 57-64.
42. Lotti T, Hautmann G and Panconesi E. 1995. Neuropeptides in skin. J Am Acad Dermatol 33: 482-496.
43. Manuskiatti W and Fitzpatrick RE. 2002. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorou racil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138: 1149-1155.
44. Morgan JR and Yarmush ML. 1997. Bioengineered skin substitutes. Sci Med 4(4): 6-15.
45. Muir IFK. 1990. On the nature of keloid and hypertrophic scars. Br J Plast Surg 43: 61-69.
46. NIESSEN FB, ANDRIESSEN MP, SCHALKWIJK J, VISSER L and Timens W. 2001. Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars. J Pathol 94: 207-216.
47. O'Sullivan ST, O'Shaughnessy M and O'Connor TP. 1996. Aetiology and management of hypertrophic scars and keloids. Ann R Coll Surg Engl 78(3Pt1): 168-175.
48. Parkhouse N, Crowe R, McGrouther DA and Burnstock G. 1992. Painful hypertrophic scarring and neuropeptides [letter]. Lancet 340: 1410.
49. Pintér E, Helyes Z, PethöG andSzolcsányi J. 1997. Noradrenergic and peptidergic sympathetic regulation of cutaneous microcirculation in the rat. Eur J Pharmacol 325: 57-64.
50. Placik OJ and Lewis VL Jr. 1992. Immunologic associations of keloids. Surg Gynecol Obstet 175(2): 185-193.
51. Rahban SR and Garner WL. 2003. Fibroproliferative scars. Clin Plast Surg 30: 77-89.
52. Ramos ML, Gragnani A and Ferreira LM. 2008. Is there an ideal animal model to study hypertrophic scar ring? J Burn Care Res 29: 363-368.
53. Rossi LA, Barruffini RCP, Garcia TR and Chianca TCM. 1998. Queimaduras: características dos casos tratados em um hospital escola em Ribeirão Preto (SP), Brasil. Rev Panam Salud Pública 4(6): 401-404.
54. Rusciani L, Paradisi A, Alfano C, Chiummariello S and Rusciani A. 2006. Cryotherapy in the treatment of keloids. J Drugs Dermatol 5(7): 591-595.
55. Sauerstein K, Klede M, Hilliges M and Schmelz M. 2000. Electrically evoked neuropeptide release and neurogenic inflammation differ between rat and human skin. J Physiol 529: 803-810.
56. Schmelz M and Petersen LJ. 2001. Neurogenic inflammation in human and rodent skin. News Physiol Sci 16: 33-37.
57. Slominski A and Wortsman J. 2000. Neuroendocrinology of the skin. Endocr Rev 21(5): 457-487.
58. Slominski A, Paus R and Schadendorf D. 1993. Melanocytes as "sensory" and regulatory cells in the epidermis. J Theor Biol 164: 103-120.
59. Slominski A, Tobin DJ, Shibahara S and Wortsman J. 2004. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84: 1155-1228.
60. Slominski A, Zbytek B, Pisarchik A, Slominski RM, Zmijewski MA and Wortsman J. 2006a. CRH functions as a growth factor/cytokine in the skin. J Cell Physiol 206: 780-791.
61. Slominski A, Zbytek B, Zmijewski M, Slominski RM, Kauser S, Wortsman J and Tobin DJ. 2006b. Corticotropin releasing hormone and the skin. Front Biosci 11: 2230-2248.
62. Sobral CS, Gragnani A, Morgan J and Ferreira LM. 2007a. Inhibition of proliferation of Pseudomonas aeruginosa by KGF in an experimental burn model using human cultured keratinocytes. Burns 33: 613-620.
63. Sobral CS, Gragnani A, Cao X, Morgan JR and Ferreira LM. 2007b. Human keratinocytes cultured on collagen matrix used as an experimental burn model. J Burns Wounds 30: 37.
64. Storm H, Myre K, Rostrup M, Stokland O, Lien MD and Raeder JC. 2002. Skin conductance correlates with perioperative stress. Acta Anaesthesiol Scand 46: 887-895.
65. Teich Alasia S, Castagnoli C, Calcagni M and Stella M. 1996. The influence of progress in the treatment of severe burns on the quality of life. Acta Chir Plast 38(4): 119-121.
66. Tompkins RG and Burke JF. 1996. Alternative Wound Coverings. In: Hendon DN (Ed), Total Burn Care, Philadelphia: W.B. Saunders Company, Philadelphia, USA, p. 164-172.
67. Toyoda M and Morohashi M. 2001. Pathogenesis of acne. Med Electron Microsc 34: 29-40.
68. Toyoda M, Luo Y, Makino T, Matsui C and Morohashi M. 1999. Calcitonin Gene-Relates Peptide upregulates melanogenesis and enhances melanocyte dendricity via induction of keratinocyte-derived melanotrophic factors. J Invest Dermatol Symp Proc 4(2): 116-125.
69. Toyoda M, Nakamura M, Makino T, Kagoura M and Morohashi M. 2002. Sebaceous glands in acne patients express high levels of neutral endopeptidase. Exp Dermatol 11(3): 241-247.
70. Tredget EE, Nedelec B, Scott PG and Ghahary A. 1997. Hypertrophic scars, keloids and contractures. Surg Clin North Am 77: 701-731.
71. Weiss DS, Kirsner R and Eaglstein WH. 1990. Electrical Stimulation and Wound Healing. Arch Dermatol 126: 222-225.
72. Youn SW, Kin DS, Cho HJ, Jeon SE, Bae IH, Yoon HJ and Park KC. 2004. Cellular senescence induced loss of stem cell proportion in skin in vitro. J Dermatol Sci 35: 113-123.
73. Zancanaro C, Merigo F, Crescimanno C, Orlandini S and Osculati A. 1999. Immunohistochemical evidence suggests intrinsic regulatory activity of human eccrine sweat glands. J Anat 194: 433-444.
74. Ziegler CG, Krug AW, Zouboulis CC and Bornstein SR. 2007. Corticotropin releasing hormone and its function in the skin. Horm Metab Res 39(2): 106-109.
75. Zouboulis CC, Seltmann H, Hiroi N, Chen W, Young M, Oeff M, Scherbaum WA, Orfanos CE, McCann SM and Bornstein SR. 2002. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci USA 99: 7148-7153.