Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A

Journal of Nutrition

Volumn 139, Issue 10, 2009, Pages 2000-2006

  Escaron, Anne L ^a   Green, Michael H ^b   Howe, Julie A ^a,c   Tanumihardjo, Sherry A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTOPE; LACTATE DEHYDROGENASE; RETINOL; RETINOL ACETATE; RETINYL ACETATE C2 13; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; COMBUSTION; COMPARTMENT MODEL; DIAGNOSTIC ACCURACY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER BIOPSY; MALE; MASS SPECTROMETRY; MATHEMATICAL MODEL; NONHUMAN; PUBLIC HEALTH; RETINOL INTOXICATION; RHESUS MONKEY; SERUM; TECHNIQUE;

ANIMALS; CARBON ISOTOPES; HYPERVITAMINOSIS A; MACACA MULATTA; MODELS, BIOLOGICAL; NUTRITIONAL REQUIREMENTS; VITAMIN A;

MACACA MULATTA; PRIMATES;

EID: 70349306423     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.111922     Document Type: Article

References (60)

1. Furr HC, Green MH, Haskell MJ, Mokhtar N, Nestel P, Newton S, Ribaya-Mercado JD, Tang G, Tanumihardjo S, et al. Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans. Public Health Nutr. 2005;8:596-607. (Pubitemid 41565424)
2. Ribaya-Mercado JD, Solomons NW, Medrano Y, Bulux J, Dolnikowski GG, Russell RM, Wallace CB. Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. Am J Clin Nutr. 2004;80:1291-1298 (Pubitemid 41350691)
3. 4]retinyl acetate in human subjects with estimated low or high total body stores of vitamin A. Am J Clin Nutr. 1998;68:90-95
4. Penniston KL, Tanumihardjo SA. Vitamin A in dietary supplements and fortified foods: too much of a good thing? J Am Diet Assoc. 2003;103:1185-1187
5. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006;83:191-201. (Pubitemid 44713178)
6. Penniston KL, Tanumihardjo SA. Subtoxic hepatic vitamin A concentrations in captive rhesus monkeys (Macaca mulatta). J Nutr. 2001;131:2904-2909 (Pubitemid 33063121)
7. Penniston KL, Thayer JC, Tanumihardjo SA. Serum vitamin A esters are high in captive rhesus (Macaca mulatta) and marmoset (Callithrix jacchus) monkeys. J Nutr. 2003;133:4202-4206
8. Baskerville M. Old World monkeys. In: Poole T, editor. The UFAW handbook on the care and management of laboratory animals. Malden (MA): Blackwell Science; 1999. p. 611-628
9. O'Toole BA, Fradkin R, Warkany J, Wilson JG, Mann GV. Vitamin A deficiency and reproduction in rhesus monkeys. J Nutr. 1974;104:1513-1524
10. Penniston KL, Tanumihardjo SA. Vitamin A intake of captive rhesus monkeys exceeds National Research Council Recommendations. Am J Primatol. 2006;68:1114-1119
11. 4-retinyl acetate and gas chromatography/combustion/ isotope ratio mass spectrometry. J Nutr. 2000;130:2844-2849
12. 4-retinyl acetate and gas chromatography-combustion isotope ratio mass spectrometry to vitamin A assessment in the human. FASEB J 2001;15:A256.
13. Guo ZK, Luke AH, Lee WP, Schoeller D. Compound-specific carbon isotope ratio determination of enriched cholesterol. Anal Chem. 1993;65:1954-1959 (Pubitemid 23978345)
14. Bier DM. Stable isotopes in biosciences, their measurement and models for amino acid metabolism. Eur J Pediatr. 1997;156 Suppl 1:S2-8.
15. Ho CC, de Moura FF, Kim S-H, Clifford AJ. Excentral cleavage of β-carotene in vivo in a healthy man. Am J Clin Nutr. 2007;85:770-777
16. Dueker SR, Lin Y, Buchholz BA, Schneider PD, Lamé MW, Segall HJ, Vogel JS, Clifford AJ. Long-term kinetic study of beta-carotene, using accelerator mass spectrometry in an adult volunteer. J Lipid Res. 2000;41:1790-1800 (Pubitemid 30839720)
17. Krause RF. Liver lipids in a case of hypervitaminosis A. Am J Clin Nutr. 1965;16:455-457
18. Muenter MD, Perry HO, Ludwig J. Chronic vitamin A intoxication in adults. Hepatic, neurologic and dermatologic complications. Am J Med. 1971;50:129-136
19. Russell RM, Boyer JL, Bagheri SA, Hruban Z. Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites. N Engl J Med. 1974;291:435-440
20. Mallia A, Smith J, Goodman D. Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat. J Lipid Res. 1975;16:180-188
21. Tanumihardjo SA. Assessing vitamin A status: past, present and future. J Nutr. 2004;134:S290-3.
22. Goodman KJ, Brenna JT. High sensitivity tracer detection using high-precision gas chromatography-combustion isotope ratio mass spectrometry and highly enriched [U-13C]-labeled precursors. Anal Chem. 1992;64:1088-1095
23. Amedee-Manesme O, Furr HC, Olson JA. The correlation between liver vitamin A concentrations in micro- (needle biopsy) and macrosamples of human liver specimens obtained at autopsy. Am J Clin Nutr. 1984;39:315-319
24. Mills JP, Terasawa E, Tanumihardjo SA. Excessive preformed vitamin A intake by mothers amplifies early fetal liver retinyl ester storage in captive Old World monkeys. Comp Med. 2007;57:505-511 (Pubitemid 351773345)
25. NRC. Nutrient requirements of nonhuman primates. 2nd ed. Washington, DC: National Academies Press; 2003.
26. 2-retinyl acetate. J Labelled Comp Radiopharm. 2001;44:365-372
27. Sabatier M, Arnaud MJ, Kastenmayer P, Rytz A, Barclay DV. Meal effect on magnesium bioavailability from mineral water in healthy women. Am J Clin Nutr. 2002;75:65-71. (Pubitemid 34008022)
28. 13C natural abundance in serum retinol acts as a biomarker for increases in dietary provitamin A. Exp Biol Med. 2009;234:140-147
29. Tanumihardjo SA, Howe JA. Twice the amount of α-carotene isolated from carrots is as effective as β-carotene in maintaining the vitamin A status of Mongolian gerbils. J Nutr. 2005;135:2622-2626
30. Bausch J, Rietz P. Method for the assessment of vitamin A liver stores. Acta Vitaminol Enzymol. 1977;31:99-112. (Pubitemid 8305707)
31. Allen LE, Green MH, Green JB. Correspondence re: SE Dew et al., Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes. Cancer Res. 53:2965-9, 1993.
32. Cancer Res. 1994;54:3319-3320
33. Brenna JT, Corso TN, Tobias HJ, Caimi RJ. High-precision continuous-flow isotope ratio mass spectrometry. Mass Spectrom Rev. 1997;16:227-258 (Pubitemid 127599641)
34. Green MH, Green JB, Lewis KC. Variation in retinol utilization rate with vitamin A status in the rat. J Nutr. 1987;117:694-703.
35. Cifelli CJ, Green JB, Green MH. Use of model-based compartmental analysis to study vitamin A kinetics and metabolism. Vitam Horm. 2007;75:161-195
36. Bourne GH, editor. The rhesus monkey. New York: Academic Press; 1975.
37. Green MH, Green JB. The application of compartmental analysis to research in nutrition. Annu Rev Nutr. 1990;10:41-61. (Pubitemid 20223383)
38. Gibson RS. Principles of nutritional assessment. New York: Oxford University Press; 1990.
39. Olson JA. Serum levels of vitamin A and carotenoids as reflectors of nutritional status. J Natl Cancer Inst. 1984;73:1439-1444
40. MedlinePlus. Comprehensive metabolic panel. In: Medical encyclopedia [cited 2009 26 Jul]. Available from: http://www.nlm.nih.gov/medlineplus/ency/ article/003468.htm).
41. MedlinePlus. Triglyceride level. In: Medical encyclopedia [cited 2009 26 Jul]. Available from http://www.nlm.nih.gov/medlineplus/ency/article/003493.htm.
42. MedlinePlus. Serum iron. In: Medical encyclopedia [cited 2009 26 Jul]. Available from http://www.nlm.nih.gov/medlineplus/ency/article/003488.htm.
43. Snedecor GW, Cochran WG. Statistical methods. 8th ed. Ames (IA): Iowa State University Press; 1989.
44. Cifelli CJ, Green JB, Wang Z, Yin S, Russell RM, Tang G, Green MH. Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. J Nutr. 2008;138:971-977 (Pubitemid 351571600)
45. Kleiber M. Body size and metabolism. Hilgardia. 1932;6:315-353
46. Mills JP, Penniston KL, Tanumihardjo SA. Extra-hepatic vitamin A concentrations in captive Rhesus (Macaca mulatta) and Marmoset (Callithrix jacchus) monkeys fed excess vitamin A. Int J Vitam Nutr Res. 2005;75:126-132
47. Higashi N, Senoo H. Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules - a comparative study. Anat Rec. 2003;271A:240-248
48. Furr HC, Amedee-Manesme O, Clifford AJ, Bergen HR III, Jones AD, Anderson DP, Olson JA. Vitamin A concentrations in liver determined by isotope dilution assay with tetradeuterated vitamin A and by biopsy in generally healthy adult humans. Am J Clin Nutr. 1989;49:713-716 (Pubitemid 19107295)
49. Haskell MJ, Handelman GJ, Peerson JM, Jones AD, Rabbi MA, Awal MA, Wahed MA, Mahalanabis D, Brown KH. Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients. Am J Clin Nutr. 1997;66:67-74. (Pubitemid 27278901)
50. Wake K. Development of vitamin A-rich lipid droplets in multivesicular bodies of rat liver stellate cells. J Cell Biol. 1974;63:683-691
51. Wake K. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol. 1980;66:303-353 (Pubitemid 10028209)
52. Sauberlich HE, Hodges RE, Wallace DL, Kolder H, Canham JE, Hood J, Raica N Jr, Lowry LK. Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam Horm. 1974;32:251-275
53. Hicks VA, Gunning DB, Olson JA. Metabolism, plasma transport and biliary excretion of radioactive vitamin A and its metabolites as a function of liver reserves of vitamin A in the rat. J Nutr. 1984;114:1327-1333
54. 4]retinyl acetate among preschool-aged, Peruvian children. Am J Clin Nutr. 2003;77:681-686
55. Tang G, Qin J, Hao LY, Yin SA, Russell RM. Use of a short-term isotope-dilution method for determining the vitamin A status of children. Am J Clin Nutr. 2002;76:413-418 (Pubitemid 34804065)
56. Haskell MJ, Mazumder RN, Peerson JM, Jones AD, Wahed MA, Mahalanabis D, Brown KH. Use of the deuterated-retinol-dilution technique to assess total-body vitamin A stores of adult volunteers consuming different amounts of vitamin A. Am J Clin Nutr. 1999;70:874-880 (Pubitemid 29512913)
57. Ribaya-Mercado JD, Solon FS, Fermin LS, Dolnikowski GG, Blumberg JB, Solon FS. Dietary vitamin A intakes of Filipino elders with adequate or low liver vitamin A concentrations as assessed by the deuterated-retinol-dilution method: implications for dietary requirements. Am J Clin Nutr. 2004;79:633-641
58. Vitamin A Tracer Task Force. Appropriate uses of vitamin A tracer (stable isotope) methodology. Washington, DC: ILSI Human Nutrition Institute; 2004.
59. Knight JA. Liver function tests: their role in the diagnosis of hepatobiliary diseases. J Infus Nurs. 2005;28:108-117 (Pubitemid 40393082)
60. Haskell M, Ribaya-Mercado JD. Vitamin A Tracer Task Force. Handbook on vitamin A tracer dilution methods to assess status and evaluate intervention programs. Technical monograph 5. Washington, DC: HarvestPlus; 2005.