Use of Model-Based Compartmental Analysis to Study Vitamin A Kinetics and Metabolism

Vitamins and Hormones

Volumn 75, Issue , 2007, Pages 161-195

  Cifelli, Christopher J ^a   Green, Joanne Balmer ^a   Green, Michael H ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOL;

ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BODY FLUID COMPARTMENT; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY; RAT; REVIEW; STATISTICAL MODEL;

ANIMALS; BODY FLUID COMPARTMENTS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; ORGAN SPECIFICITY; RATS; VITAMIN A;

EID: 33947118627     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(06)75007-5     Document Type: Review

References (82)

1. Adams W.R., and Green M.H. Prediction of liver vitamin A in rats by an oral isotope dilution technique. J. Nutr. 124 (1994) 1265-1270
2. Adams W.R., Smith J.E., and Green M.H. Effects of N-(4-hydroxyphenyl)retinamide on vitamin A metabolism in rats. Proc. Soc. Exp. Biol. Med. 208 (1995) 178-185
3. Adiels M., Packard C., Caslake M.J., Stewart P., Soro A., Westerbacka J., Wennberg B., Olofsson S.O., Taskinen M.R., and Boren J. A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions. J. Lipid Res. 46 (2005) 58-67
4. Anonymous. "Turnover" of vitamin A. Nutr. Rev. 35 (1977) 310-313
5. Berman M., and Weiss M.F. "SAAM 27." (1978) DHEW Publication No. (NIH) 78-180. Washington, DC
6. In: Berman M., Grundy S.M., and Howard B.V. (Eds). "Lipoprotein Kinetics and Modeling." (1982), Academic Press, New York
7. Biesalski H.K., and Nohr D. Importance of vitamin-A for lung function and development. Mol. Aspects Med. 24 (2003) 431-440
8. Birge S.J., Peck W.A., Berman M., and Whedon G.D. Study of calcium absorption in man: A kinetic analysis and physiologic model. J. Clin. Invest. 48 (1969) 1705-1713
9. Blaner W.S., Smith J.E., Dell R.B., and Goodman D.S. Spatial distribution of retinol-binding protein and retinyl palmitate hydrolase activity in normal and vitamin A-deficient rat liver. J. Nutr. 115 (1985) 856-864
10. Blomhoff R., Rasmussen M., Nilsson A., Norum K.R., Berg T., Blaner W.S., Kato M., Mertz J.R., Goodman D.S., Ericksson U., and Peterson P.A. Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. J. Biol. Chem. 260 (1985) 13560-13565
11. Blomhoff R., Nenseter M.S., Green M.H., and Berg T. A multicompartmental model of fluid-phase endocytosis in rabbit liver parenchymal cells. Biochem. J. 262 (1989) 605-610
12. Blomhoff R., Green M.H., Green J.B., Berg T., and Norum K.R. Vitamin A metabolism: New perspectives on absorption, transport, and storage. Physiol. Rev. 71 (1991) 951-990
13. Carney S.M., Underwood B.A., and Loerch J.D. Effects of zinc and vitamin A deficient diets on the hepatic mobilization and urinary excretion of vitamin A in rats. J. Nutr. 106 (1976) 1773-1781
14. Carson E.R., Cobelli C., and Finkelstein L. "The Mathematical Modeling of Metabolic and Endocrine Systems: Model Formulation, Identification, and Validation." (1983), John Wiley and Sons, New York
15. Christensen E.I., Moskaug J.O., Vorum H., Jacobsen C., Gundersen T.E., Nykaer A., Blomhoff R., Wilnow T.E., and Muestrup S.K. Evidence for an essential role of megalin in transepithelial transport of retinol. J. Am. Soc. Nephrol. 10 (1999) 685-695
16. Cifelli C.J., Green J.B., and Green M.H. Dietary retinoic acid alters vitamin A kinetics in both the whole body and in specific organs of rats with low vitamin A status. J. Nutr. 135 (2005) 746-752
17. Coburn S.P., Townsend D.W., Ericson K.L., Reynolds R.D., Ziegler P.J., Costill D.L., Mahuren J.D., Schaltenbrand W.E., Pauly T.A., Wang Y., Fink W.J., Pearson D.R., et al. Modeling short (7 hour)- and long (6 week)-term kinetics of vitamin B-6 metabolism with stable isotopes in humans. In: Novotny J.A., Green M.H., and Boston R.C. (Eds). "Mathematical Modeling in Nutrition and the Health Sciences" (2003), Kluwer Academic/Plenum Publishers, New York 173-192
18. DiStefano III J.J., and Landaw E.M. Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations. Am. J. Physiol. 246 (1984) R651-R664
19. Dowling J.E., and Wald G. The biological function of vitamin A acid. Proc. Natl. Acad. Sci. USA 46 (1960) 587-608
20. Duncan T.E., Green J.B., and Green M.H. Liver vitamin A levels in rats are predicted by a modified isotope dilution technique. J. Nutr. 123 (1993) 933-939
21. Foster D.M., and Boston R.C. The use of computers in compartmental analysis: The SAAM and CONSAM programs. In: Robertson J.S. (Ed). "Compartmental Distribution of Radiotracers" (1983), CRC Press, Boca Raton 73-142
22. Foster D.M., Aamodt R.L., Henkin R.I., and Berman M. Zinc metabolism in humans: A kinetic model. Am. J. Physiol. 237 (1979) R340-R349
23. Furr H.C., Green M.H., Haskell M., Mokhtar N., Nestel P., Newton S., Ribaya-Mercado J.D., Tang G., Tanumihardjo S., and Wasantwisut E. Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans. Public Health Nutr. 8 (2005) 596-607
24. Gieng S.H. Kinetic analysis and dynamics of inflammation-induced hyporetinolemia in the rat. (2006), The Pennsylvania State University, University Park, PA Doctoral dissertation
25. Gieng S.H., Patel D., Green M.H., Green J.B., and Rosales F.J. Model-based compartmental analysis indicates a reduced mobilization of hepatic vitamin A during inflammation in rats. FASEB J. 19 (2005) A442 (abs. 279.9)
26. Green M.H. Introduction to modeling. J. Nutr. 122 (1992) 690-694
27. Green M.H., and Green J.B. Multicompartmental analysis of whole body retinol dynamics in vitamin A-sufficient rats. Fed. Proc. 46 (1987) 1011 (abs. 4047)
28. Green M.H., and Green J.B. The application of compartmental analysis to research in nutrition. Annu. Rev. Nutr. 10 (1990) 41-61
29. Green M.H., and Green J.B. Experimental and kinetic methods for studying vitamin A dynamics in vivo. Meth. Enzymol. 190 (1990) 304-317
30. Green M.H., and Green J.B. Vitamin A intake and status influence retinol balance, utilization and dynamics in rats. J. Nutr. 124 (1994) 2477-2485
31. Green M.H., and Green J.B. Dynamics and control of plasma retinol. In: Blomhoff R. (Ed). "Vitamin A in Health and Disease" (1994), Marcel Dekker, Inc., New York 119-133
32. Green M.H., and Green J.B. Quantitative and conceptual contributions of mathematical modeling to current views on vitamin A metabolism, biochemistry, and nutrition. Adv. Food Nutr. Res. 40 (1996) 3-24
33. Green M.H., and Green J.B. The use of model-based compartmental analysis to study vitamin A metabolism in a non-steady state. In: Novotny J.A., Green M.H., and Boston R.C. (Eds). "Mathematical Modeling in Nutrition and the Health Sciences" (2003), Kluwer Academic/Plenum Publishers, New York 159-172
34. Green M.H., and Green J.B. Contributions of mathematical modeling to understanding whole-body vitamin A metabolism and to the assessment of vitamin A status. Sight Life Newsletter 2 (2005) 4-10
35. Green M.H., and Green J.B. The application of model-based compartmental analysis to the study of the kinetic behavior of vitamin A in vitamin A-sufficient rats: Validation of a theoretical model. In: Hargrove J.L., and Berdanier C.D. (Eds). "Mathematical Modeling in Nutrition and Toxicology" (2005), Mathematical Biology Press, Athens 175-187
36. Green M.H., Uhl L., and Green J.B. A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores. J. Lipid Res. 26 (1985) 806-818
37. Green M.H., Green J.B., and Lewis K.C. Variation in retinol utilization rate with vitamin A status in the rat. J. Nutr. 117 (1987) 694-703
38. Green M.H., Green J.B., and Lewis K.C. Model-based compartmental analysis of retinol kinetics in organs of rats at different levels of vitamin A status. In: Livrea M., and Packer L. (Eds). "Retinoids: Progress in Research and Clinical Applications" (1992), Marcel Dekker, New York 185-204
39. Green M.H., Green J.B., Berg T., Nourm K.R., and Blomhoff R. Vitamin A metabolism in rat liver: A kinetic model. Am. J. Physiol. 264 (1993) G509-G521
40. Gudas L., Sporn M.B., and Roberts A.B. Cellular biology and biochemistry of the retinoids. In: Sporn M.B., Roberts A.B., and Goodman D.S. (Eds). "The Retinoids". 2nd ed. (1994), Raven Press, New York 444-520
41. Hargrove J.L. "Dynamic Modeling in the Health Sciences." (1998), Springer-Verlag, New York
42. Harrison E.H., and Gad M.Z. Hydrolysis of retinyl palmitate by enzymes of rat pancreas and liver. Differentiation of bile salt-dependent and bile salt-independent, neutral retinyl ester hydrolases in rat liver. J. Biol. Chem. 264 (1989) 17142-17147
43. Hicks V.A., Gunning D.B., and Olson J.A. Metabolism, plasma transport and biliary excretion of radioactive vitamin A and its metabolites as a function of liver reserves of vitamin A in the rat. J. Nutr. 114 (1984) 1327-1333
44. Jang J.-T., Green J.B., Beard J.L., and Green M.H. Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats. J. Nutr. 130 (2000) 1291-1296
45. Kelley S.K., and Green M.H. Plasma retinol is a major determinant of vitamin A utilization in rats. J. Nutr. 128 (1998) 1767-1773
46. Kelley S.K., Nilsson C.B., Green M.H., Green J.B., and Håkansson H. Use of model-based compartmental analysis to study effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A kinetics in rats. Toxicol. Sci. 44 (1998) 1-13
47. Kelley S.K., Nilsson C.B., Green M.H., Green J.B., and Håkansson H. Mobilization of vitamin A stores in rats after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin: A kinetic analysis. Toxicol. Sci. 55 (2000) 478-484
48. Lamb A.J., Apiwatanaporn P., and Olson J.A. Induction of rapid, synchronous vitamin A deficiency in the rat. J. Nutr. 104 (1974) 1140-1148
49. Landaw E.M., and DiStefano III J.J. Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations. Am. J. Physiol. 246 (1984) R665-R677
50. Lewis K.C. Multicompartmental tracer kinetic analysis of retinol metabolism in rats with low vitamin A status (1987), The Pennsylvania State University, University Park, PA Doctoral dissertation
51. Lewis K.C., Green M.H., and Underwood B.A. Vitamin A turnover in rats as influenced by vitamin A status. J. Nutr. 111 (1981) 1135-1144
52. Lewis K.C., Green M.H., Green J.B., and Zech L.A. Retinol metabolism in rats with low vitamin A status: A compartmental model. J. Lipid Res. 31 (1990) 1535-1548
53. Livera G., Rouiller-Fabre V., Pairault C., Levacher C., and Habert R. Regulation and perturbation of testicular functions by vitamin A. Reproduction 124 (2002) 173-180
54. Lyne A., Boston R., Pettigrew K., and Zech L. EMSA: A SAAM service for the estimation of population parameters based on model fits to identically replicated experiments. Comput. Methods Program Biomed. 38 (1992) 117-151
55. Malmendier C.L., Delcroix C., and Berman M. Interrelations in the oxidative metabolism of free fatty acids, glucose, and glycerol in normal and hyperlipemic patients. A compartmental model. J. Clin. Invest. 54 (1974) 461-476
56. Moore-Colyer M.J., Morrow H.J., and Longland A.C. Mathematical modelling of digesta passage rate, mean retention time and in vivo apparent digestibility of two different lengths of hay and big-bale grass silage in ponies. Br. J. Nutr. 90 (2003) 109-118
57. In: Novotny J.A., Green M.H., and Boston R.C. (Eds). "Mathematical Modeling in Nutrition and the Health Sciences." (2003), Kluwer Academic/Plenum Publishers, New York
58. Olson J.A., Rojanapo W., and Lamb A.J. The effect of vitamin A status on the differentiation and function of goblet cells in the rat intestine. Ann. NY Acad. Sci. 359 (1981) 181-191
59. Pinna K., Woodhouse L.R., Sutherland B., Shames D.M., and King J.C. Exchangeable zinc pool masses and turnover are maintained in healthy men with low zinc intakes. J. Nutr. 131 (2001) 2288-2294
60. Raila J., Willnow T.E., and Schweigert F.J. Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis. J. Nutr. 135 (2005) 2512-2516
61. Redgrave T.G., Ly H.L., Quintao E.C.R., Ramberg C.F., and Boston R.C. Clearance from plasma of triacylglycerol and cholesteryl ester after intravenous injection of chylomicron-like lipid emulsions in rats and man. Biochem. J. 290 (1993) 843-847
62. Rietz P., Vuilleumier J.P., Weber F., and Wiss O. Determination of the vitamin A bodypool of rats by an isotopic dilution method. Experientia 29 (1973) 168-170
63. Rietz P., Wiss O., and Weber F. Metabolism of vitamin A and the determination of vitamin A status. Vitam. Horm. 32 (1974) 237-249
64. In: Robertson J.S. (Ed). "Compartmental Distribution of Radiotracers." (1983), CRC Press, Boca Raton
65. Ross A.C. Retinoid production and catabolism: Role of diet in regulating retinol esterification and retinoic acid oxidation. J. Nutr. 133 (2003) 291S-296S
66. Ross A.C. Hepatic metabolism of vitamin A. In: Zakim D., and Boyer T. (Eds). "Hepatology: A Textbook of Liver Disease" (2003), Saunders, Philadelphia 149-168
67. Ross A.C., and Zolfaghari R. Regulation of hepatic retinol metabolism: Perspectives from studies on vitamin A status. J. Nutr. 134 (2004) 269S-275S
68. Sauberlich H.E., Hodges R.E., Wallace D.L., Kolder H., Canham J.E., Hood J., Raica Jr. N., and Lowry L.K. Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam. Horm. 32 (1974) 251-275
69. Sewell H.B., Mitchell Jr. G.E., Little C.O., and Hayes B.W. Mobilization of liver vitamin A in rats. Int. Z. Vitaminforsch. 37 (1967) 301-306
70. Soprano D.R., and Soprano K.J. Role of RARs and RXRs in mediating the molecular mechanism of action of vitamin A. In: Zemplenic J., and Daniel H. (Eds). "Molecular Nutrition" (2003), CABI Publishing, Cambridge 135-149
71. Soprano D.R., Soprano K.J., and Goodman D.S. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. J. Lipid Res. 27 (1986) 166-171
72. Stefanovski D., Moate P.J., and Boston R.C. WinSAAM: A Windows-based compartmental modeling system. Metabolism 52 (2003) 1153-1166
73. Sundaresan P.R. Rate of metabolism of retinol in retinoic acid-maintained rats after a single dose of radioactive retinol. J. Nutr. 107 (1977) 70-78
74. Tang G., Qin J., Dolnikowski G.G., and Russell R.M. Short-term (intestinal) and long-term (postintestinal) conversion of β-carotene to retinol in adults as assessed by a stable-isotope reference method. Am. J. Clin. Nutr. 78 (2003) 259-266
75. von Reinersdorff D., Green M.H., and Green J.B. Development of a compartmental model describing the dynamics of vitamin A metabolism in men. Adv. Exp. Biol. Med. 445 (1998) 207-223
76. Wald G. Molecular basis of visual excitation. Science 162 (1968) 230-239
77. Wastney M.E., Angelus P., Barnes R.M., and Subramanian K.N. Zinc kinetics in preterm infants: A compartmental model based on stable isotope data. Am. J. Physiol. 271 (1996) R1452-R1459
78. Wastney M.E., Pattterson B.H., Linares O.A., Greif P.C., and Boston R.C. "Investigating Biological Systems Using Modeling: Strategies and Software." (1999), Academic Press, San Diego
79. WinSAAM: The Simulation, Analysis and Modeling Software. http://www.WinSAAM.com
80. Wolbach S.B., and Howe P.R. Tissue changes following deprivation of fat soluble A vitamin. J. Exp. Med. 42 (1925) 453-457
81. Zile M., Bunge E.C., and DeLuca H.F. Effect of vitamin A deficiency on intestinal cell proliferation. J. Nutr. 107 (1977) 552-560
82. Zile M.H. Vitamin A homeostasis endangered by environmental pollutants. Proc. Soc. Exp. Biol. Med. 201 (1992) 141-153