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Volumn 21, Issue 5, 2009, Pages 239-245

Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial

Author keywords

Alcohol; Bipolar disorder; Caffeine; Clinical trial; N acetyl cysteine; Smoking; Substance use

Indexed keywords

ACETYLCYSTEINE; CAFFEINE; PLACEBO;

EID: 70349304388     PISSN: 09242708     EISSN: 16015215     Source Type: Journal    
DOI: 10.1111/j.1601-5215.2009.00415.x     Document Type: Article
Times cited : (11)

References (37)
  • 1
    • 21244483048 scopus 로고    scopus 로고
    • The management of bipolar disorder in primary care: A review of existing and emerging therapies
    • DOI 10.1111/j.1440-1819.2005.01365.x
    • Berk M, Dodd S, Berk L. The management of bipolar disorder in primary care: a review of existing and emerging therapies. Psychiatry Clin Neurosci 2005 59 : 229 239. (Pubitemid 40897192)
    • (2005) Psychiatry and Clinical Neurosciences , vol.59 , Issue.3 , pp. 229-239
    • Berk, M.1    Dodd, S.2    Berk, L.3
  • 2
    • 0025226205 scopus 로고
    • Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.
    • Regier DA, Farmer ME, Rae DS et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 1990 264 : 2511 2518.
    • (1990) JAMA , vol.264 , pp. 2511-2518
    • Regier, D.A.1    Farmer, M.E.2    Rae, D.S.3
  • 3
    • 0032749294 scopus 로고    scopus 로고
    • A history of substance abuse complicates remission from acute mania in bipolar disorder
    • Goldberg JF, Garno JL, Leon AC, Kocsis JH, Portera L. A history of substance abuse complicates remission from acute mania in bipolar disorder. J Clin Psychiatry 1999 60 : 733 740.
    • (1999) J Clin Psychiatry , vol.60 , pp. 733-740
    • Goldberg, J.F.1    Garno, J.L.2    Leon, A.C.3    Kocsis, J.H.4    Portera, L.5
  • 4
    • 0027519498 scopus 로고
    • Drug-induced hepatic disorders. Incidence, management and avoidance.
    • Dossing M, Sonne J. Drug-induced hepatic disorders. Incidence, management and avoidance. Drug Saf 1993 9 : 441 449.
    • (1993) Drug Saf , vol.9 , pp. 441-449
    • Dossing, M.1    Sonne, J.2
  • 6
    • 58749094797 scopus 로고    scopus 로고
    • Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: A comparative study with amphetamine and diazepam
    • Castro AA, Moretti M, Casagrande TS et al. Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: a comparative study with amphetamine and diazepam. Pharmacol Biochem Behav 2009 91 : 636 642.
    • (2009) Pharmacol Biochem Behav , vol.91 , pp. 636-642
    • Castro, A.A.1    Moretti, M.2    Casagrande, T.S.3
  • 9
    • 34250318164 scopus 로고    scopus 로고
    • Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects
    • Machado-Vieira R, Andreazza AC, Viale CI et al. Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett 2007 421 : 33 36.
    • (2007) Neurosci Lett , vol.421 , pp. 33-36
    • MacHado-Vieira, R.1    Andreazza, A.C.2    Viale, C.I.3
  • 10
    • 33846889102 scopus 로고    scopus 로고
    • Serum S100B and antioxidant enzymes in bipolar patients
    • Andreazza AC, Cassini C, Rosa AR et al. Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res 2007 41 : 523 529.
    • (2007) J Psychiatr Res , vol.41 , pp. 523-529
    • Andreazza, A.C.1    Cassini, C.2    Rosa, A.R.3
  • 11
    • 33845866091 scopus 로고    scopus 로고
    • Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report
    • Frey BN, Andreazza AC, Kunz M et al. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog Neuropsychopharmacol Biol Psychiatry 2007 31 : 283 285.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 283-285
    • Frey, B.N.1    Andreazza, A.C.2    Kunz, M.3
  • 12
    • 33846817069 scopus 로고    scopus 로고
    • Assessment of malondialdehyde levels in schizophrenia: A meta-analysis and some methodological considerations
    • Grignon S, Chianetta JM. Assessment of malondialdehyde levels in schizophrenia: a meta-analysis and some methodological considerations. Prog Neuropsychopharmacol Biol Psychiatry 2007 31 : 365 369.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 365-369
    • Grignon, S.1    Chianetta, J.M.2
  • 13
    • 58549093744 scopus 로고    scopus 로고
    • Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: A positive correlation
    • Gama CS, Berk M, Andreazza AC, Kapczinski F, Belmonte-de-Abreu P. Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation. Rev Bras Psiquiatr 2008 30 : 337 340.
    • (2008) Rev Bras Psiquiatr , vol.30 , pp. 337-340
    • Gama, C.S.1    Berk, M.2    Andreazza, A.C.3    Kapczinski, F.4    Belmonte-De-Abreu, P.5
  • 14
    • 33646479818 scopus 로고    scopus 로고
    • Silva Belmonte-de-Abreu P. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: A study of patients treated with haloperidol or clozapine.
    • Gama CS, Salvador M, Andreazza AC, Kapczinski F, Silva Belmonte-de-Abreu P. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine. Prog Neuropsychopharmacol Biol Psychiatry 2006 30 : 512 515.
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , pp. 512-515
    • Gama, C.S.1    Salvador, M.2    Andreazza, A.C.3    Kapczinski, F.4
  • 15
    • 40849114503 scopus 로고    scopus 로고
    • Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males
    • Gama CS, Salvador M, Andreazza AC et al. Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males. Neurosci Lett 2008 433 : 270 273.
    • (2008) Neurosci Lett , vol.433 , pp. 270-273
    • Gama, C.S.1    Salvador, M.2    Andreazza, A.C.3
  • 16
    • 36549053586 scopus 로고    scopus 로고
    • Drug addiction as a pathology of staged neuroplasticity
    • Kalivas PW, O'Brien C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 2008 33 : 166 180.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 166-180
    • Kalivas, P.W.1    O'Brien, C.2
  • 17
    • 27144492384 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in bipolar disorder: Evidence from magnetic resonance spectroscopy research
    • Stork C, Renshaw PF. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005 10 : 900 919.
    • (2005) Mol Psychiatry , vol.10 , pp. 900-919
    • Stork, C.1    Renshaw, P.F.2
  • 18
    • 38349032561 scopus 로고    scopus 로고
    • Lack of changes in the concentration of thiobarbituric acid-reactive substances (TBARS) and in the activities of erythrocyte antioxidant enzymes in alcohol-dependent patients after detoxification
    • Wozniak B, Musialkiewicz D, Wozniak A et al. Lack of changes in the concentration of thiobarbituric acid-reactive substances (TBARS) and in the activities of erythrocyte antioxidant enzymes in alcohol-dependent patients after detoxification. Med Sci Monit 2008 14 : CR32 CR36.
    • (2008) Med Sci Monit , vol.14
    • Wozniak, B.1    Musialkiewicz, D.2    Wozniak, A.3
  • 19
    • 0037743546 scopus 로고    scopus 로고
    • Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    • Baker DA, McFarland K, Lake RW et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neuroscience 2003 6 : 743 749.
    • (2003) Nat Neuroscience , vol.6 , pp. 743-749
    • Baker, D.A.1    McFarland, K.2    Lake, R.W.3
  • 20
    • 21844443565 scopus 로고    scopus 로고
    • Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    • Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 2005 25 : 6389 6393.
    • (2005) J Neurosci , vol.25 , pp. 6389-6393
    • Moran, M.M.1    McFarland, K.2    Melendez, R.I.3    Kalivas, P.W.4    Seamans, J.K.5
  • 21
    • 0037693859 scopus 로고    scopus 로고
    • Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior
    • McFarland K, Lapish CC, Kalivas PW. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 2003 23 : 3531 3537.
    • (2003) J Neurosci , vol.23 , pp. 3531-3537
    • McFarland, K.1    Lapish, C.C.2    Kalivas, P.W.3
  • 22
    • 38449086396 scopus 로고    scopus 로고
    • Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine
    • Madayag A, Lobner D, Kau KS et al. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci 2007 27 : 13968 13976.
    • (2007) J Neurosci , vol.27 , pp. 13968-13976
    • Madayag, A.1    Lobner, D.2    Kau, K.S.3
  • 23
    • 37849026004 scopus 로고    scopus 로고
    • N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking
    • Zhou W, Kalivas PW. N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biol Psychiatry 2008 63 : 338 340.
    • (2008) Biol Psychiatry , vol.63 , pp. 338-340
    • Zhou, W.1    Kalivas, P.W.2
  • 24
    • 34548150512 scopus 로고    scopus 로고
    • N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: A pilot study
    • Grant JE, Kim SW, Odlaug BL. N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study. Biol Psychiatry 2007 62 : 652 657.
    • (2007) Biol Psychiatry , vol.62 , pp. 652-657
    • Grant, J.E.1    Kim, S.W.2    Odlaug, B.L.3
  • 25
    • 0024512008 scopus 로고
    • Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration
    • Burgunder JM, Varriale A, Lauterburg BH. Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 1989 36 : 127 131.
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 127-131
    • Burgunder, J.M.1    Varriale, A.2    Lauterburg, B.H.3
  • 26
    • 0025959339 scopus 로고
    • Clinical pharmokinetics of N-acetylcysteine
    • Holdiness MR. Clinical pharmokinetics of N-acetylcysteine. Clincal Pharmokinetics 1991 20 : 123 134.
    • (1991) Clincal Pharmokinetics , vol.20 , pp. 123-134
    • Holdiness, M.R.1
  • 27
    • 38949218189 scopus 로고    scopus 로고
    • N-acetylcysteine treatment inhibits depletion of brain glutathione levels in rats: Implications for schizophrenia.
    • Dean O, van den Buuse M, Copolov DL, Berk M, Bush AI. N-acetylcysteine treatment inhibits depletion of brain glutathione levels in rats: implications for schizophrenia. Int J Neuropsychopharmacol 2004 7 : S262.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 262
    • Dean, O.1    Van Den Buuse, M.2    Copolov, D.L.3    Berk, M.4    Bush, A.I.5
  • 28
    • 0034601439 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis
    • Andreassen OA, Dedeoglu A, Klivenyi P, Beal MF, Bush AI. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. NeuroReport 2000 11 : 2491 2493.
    • (2000) NeuroReport , vol.11 , pp. 2491-2493
    • Andreassen, O.A.1    Dedeoglu, A.2    Klivenyi, P.3    Beal, M.F.4    Bush, A.I.5
  • 29
    • 0029040463 scopus 로고
    • Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis
    • Louwerse ES, Weverling GJ, Bossuyt PM, Meyjes FE, de Jong JM. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol 1995 52 : 559 564.
    • (1995) Arch Neurol , vol.52 , pp. 559-564
    • Louwerse, E.S.1    Weverling, G.J.2    Bossuyt, P.M.3    Meyjes, F.E.4    De Jong, J.M.5
  • 31
    • 0033043959 scopus 로고    scopus 로고
    • In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage
    • Koppal T, Drake J, Butterfield DA. In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage. Biochimica et Biophysica Acta 1999 1453 : 407 411.
    • (1999) Biochimica et Biophysica Acta , vol.1453 , pp. 407-411
    • Koppal, T.1    Drake, J.2    Butterfield, D.A.3
  • 32
    • 0028169881 scopus 로고
    • N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro
    • Mayer M, Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A 1994 91 : 7496 7500.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7496-7500
    • Mayer, M.1    Noble, M.2
  • 33
    • 0029175712 scopus 로고
    • Redox regulation of activation of NF-kappa B transcription factor complex: Effects of N-acetylcysteine
    • Staal FJ, Anderson MT, Herzenberg LA. Redox regulation of activation of NF-kappa B transcription factor complex: effects of N-acetylcysteine. Methods Enzymol 1995 252 : 168 174.
    • (1995) Methods Enzymol , vol.252 , pp. 168-174
    • Staal, F.J.1    Anderson, M.T.2    Herzenberg, L.A.3
  • 34
    • 0028916027 scopus 로고
    • N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells
    • Ferrari G, Yan CY, Greene LA. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 1995 15 : 2857 2866.
    • (1995) J Neurosci , vol.15 , pp. 2857-2866
    • Ferrari, G.1    Yan, C.Y.2    Greene, L.A.3
  • 35
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O et al. N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry 2008 64 : 361 368.
    • (2008) Biol Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 36
    • 49749109893 scopus 로고    scopus 로고
    • N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial
    • Berk M, Copolov DL, Dean O et al. N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008 64 : 468 475.
    • (2008) Biol Psychiatry , vol.64 , pp. 468-475
    • Berk, M.1    Copolov, D.L.2    Dean, O.3
  • 37
    • 0003412410 scopus 로고
    • Rockville, MD. U.S. National Institute of Health, Psychopharmacology Research Branch
    • Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD : U.S. National Institute of Health, Psychopharmacology Research Branch, 1976.
    • (1976) ECDEU Assessment Manual for Psychopharmacology.
    • Guy, W.1


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