Small molecule dnak modulators targeting the β-domain

Chemical Biology and Drug Design

Volumn 74, Issue 4, 2009, Pages 349-357

  Cellitti, Jason ^a   Zhang, Ziming ^a   Wang, Si ^a   Wu, Bainan ^a   Yuan, Hongbin ^a   Hasegawa, Patty ^b   Guiney, Donald G ^b   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Allostery; Chaperone; DnaK; Drug discovery; NMR

Indexed keywords

[4 (2 HYDROXYETHYL)PIPERAZIN 1 YL](THIOPHEN 2 YL)METHANONE; AMIDE; ANTIINFECTIVE AGENT; N (1H INDOL 5 YL)THIOPHENE 2 CARBOXAMIDE; N (2 HYDROXYBENZYL)THIOPHENE 2 CARBOXAMIDE; N (2,6 DICHLOROBENZYL)THIOPHENE 2 CARBOXAMIDE; N (3,4 DICHLOROBENZYL)THIOPHENE 2 CARBOXAMIDE; N (3,5 DICHLOROBENZYL)THIOPHENE 2 CARBOXAMIDE; N (BENZO[B]THIOPHEN 7 YLMETHYL)THIOPHENE 2 CARBOXAMIDE; N (NAPHTHALEN 1 YLMETHYL)THIOPHENE 2 CARBOXAMIDE; N (QUINAZOLIN 2 YL)THIOPHENE 2 CARBOXAMIDE; PROTEIN DNAK; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; ISOTHERMAL TITRATION CALORIMETRY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; YERSINIA PSEUDOTUBERCULOSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; ESCHERICHIA COLI PROTEINS; HSP70 HEAT-SHOCK PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); YERSINIA PSEUDOTUBERCULOSIS;

EID: 70349292883     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00869.x     Document Type: Article

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