Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding

Synapse

Volumn 63, Issue 11, 2009, Pages 972-981

  Yang, Andrew Rong Song Tzeng ^a   Heon, Soo Yi ^a   Mamczarz, Jacek ^a   June Jr , Harry L ^a   Hwang, Bang H ^b   June Sr , Harry L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Alcohol intake; Alcohol preference; Anxiety; Central nucleus of the amygdala; Substance P mRNA

Indexed keywords

ALCOHOL; CARCINOEMBRYONIC ANTIGEN; MESSENGER RNA; SUBSTANCE P; SUCROSE;

ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; AUTORADIOGRAPHY; CAUDATE NUCLEUS; CONTROLLED STUDY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROANATOMY; NONHUMAN; PRIORITY JOURNAL; RAT;

ALCOHOLISM; AMYGDALA; ANIMALS; ANXIETY; AUTORADIOGRAPHY; BEHAVIOR, ADDICTIVE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; IN SITU HYBRIDIZATION; MALE; MOTIVATION; RATS; RNA, MESSENGER; SUBSTANCE P;

EID: 70349289968     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20677     Document Type: Article

References (64)

1. Acsady L, Katona I, Gulyas AI, Shigemoto R, Freund TF. 1997. Immunostaining for substance P receptor labels GABAergic cells with distinct termination patterns in the hippocampus. J Comp Neurol 378:320-336. (Pubitemid 27061459)
2. Bychkov EP, Lebedev AA, Dambinova SA. 2001. Effect of substance P on ethanol consumption in subchronically alcoholized rats in the limited scheduled access paradigm (Russian). Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 51:120-122.
3. Carletti R, Corsi M, Melotto S, Caberlotto L. 2005. Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. Eur J Neurosci 21:1712-1718. (Pubitemid 40646616)
4. Chen LW, Cao R, Liu HL, Ju G, Chan YS. 2003. The striatal GABA-ergic neurons expressing substance P receptors in the basal ganglia of mice. Neuroscience 119:919-925. (Pubitemid 36776443)
5. Dam TV, Martinelli B, Quirion R. 1990. Autoradiographic distribution of brain neurokinin-1/substance P receptors using a highly selective ligand [3H]-[Sar9,Met(O2)11]-substance P. Brain Res 531:333-337.
6. Ehlers CL, Chaplin RI, Wall TL, Lumeng L, Li TK, Owens MJ, Nemeroff CB. 1992. Corticotropin releasing factor (CRF): Studies in alcohol preferring and non-preferring rats. Psychopharmacology (Berl) 106:359-364.
7. Eiler WJ II, Seyoum R, Foster KL, Mailey C, June HL. 2003. D1 dopamine receptor regulates alcohol-motivated behaviors in the bed nucleus of the stria terminalis in alcohol-preferring (P) rats. Synapse 48:45-56. (Pubitemid 36249891)
8. Emson PC, Jessell T, Paxinos G, Cuello AC. 1978. Substance P in the amygdaloid complex, bed nucleus and stria terminalis of the rat brain. Brain Res 149:97-105. (Pubitemid 8350026)
9. File SE. 1997. Anxiolytic action of a neurokinin 1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav 58:747-752.
10. Foster KL, McKay PF, Seyoum R, Milbourne D, Yin W, Sarma PV, Cook JM, June HL. 2004. GABAA and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors. Neuropsychophamarcology 29:269-284. (Pubitemid 38175146)
11. Funk CK, Koob GF. 2007. A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Res 1155:172-178.
12. Funk CK, O'Dell LE, Crawford EF, Koob GF. 2006. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci 26:11324-11332.
13. George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. 2008. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319:1536-1539.
14. Harlan RE, Garcia MM, Krause JE. 1989. Cellular localization of substance P- and neurokinin A-encoding preprotachykinin mRNA in the female rat brain. J Comp Neurol 287:179-212.
15. Hasenohrl RU, Jentjens O, De Souza Silva MA, Tomaz C, Huston JP. 1998. Anxiolytic-like action of neurokinin substance P administered systemically or into the nucleus basalis magnocellularis region. Eur J Pharmacol 354:123-133. (Pubitemid 28401444)
16. Heilig M, Koob GF, Ekman R, Britton KT. 1994. Corticotropin-releasing factor and neuropeptide Y: Role in emotional integration. Trends Neurosci 17:80-85. (Pubitemid 24033179)
17. Hwang BH, Guntz JM. 1997. Downregulation of corticotropin-releasing factor mRNA, but not vasopressin mRNA in the paraventricular hypothalamic nucleus of rats following nutritional stress. Brain Res Bull 43:509-514.
18. Hwang BH, Stewart RB, Lumeng L, Li TK. 2001. The down-regulation of corticotropin releasing factor gene expression in the central nucleus of the amygdala is associated with high alcohol preference and anxiety in alcohol-preferring (P) rats. Soc Neurosci Abstr 27:732.11.
19. Hwang BH, Suzuki R, Lumeng L, Li TK, McBride W. 2004a.Characteristic distribution of neuropeptide Y (NPY) mRNA in the discrete brain regions: Absence of NPY mRNA in the medial habenular nucleus of alcohol-preferring (P) rats. In: Proceedings of Seventh International NPY meeting, Coimbra, Portugal, February 3-7, 2004. p 88.
20. Hwang BH, Stewart R, Zhang JK, Lumeng L, Li TK. 2004b. Corticotropin releasing factor (CRF) gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: A comparison between rat lines selectively bred for high and low alcohol preference. Brain Res 1026:143-150. (Pubitemid 39336425)
21. Hwang BH, Suzuki R, Lumeng L, Li TK, McBride WJ. 2004c. Innate difference in neuropeptide Y (NPY) mRNA expression in discrete brain regions between alcohol-preferring (P) and-nonpreferring (NP) rats: A significantly low level of NPY mRNA in dentate gyrus of the hippocampus and absence of NPY mRNA in the medial habenular nucleus of P rats. Neuropeptides 38:359-368.
22. Hwang BH, Gu ZH, June HL. 2005a. Role of substance P (SP) in alcohol drinking: Studies from SP mRNA to alcohol-motivated behaviors. Soc Neurosci Abstr 35:680.4.
23. Hwang BH, Katner J, Iyengar S. 2005b. Corticotropin-releasing factor mRNA and substance P receptor binding in the paraventricular hypothalamic nucleus, central nucleus of the amygdala, and locus coeruleus of Sprague-Dawley rats following restraint-induced stress. J Mol Neurosci 25:239-250. (Pubitemid 41389348)
24. June HL. 2002. Alcohol initiation procedures in rats: Methods used in evaluating potential pharmacotherapeutic agents. In: Crawley J, Gerfen C, McKay R, Rogawski M, Sibley D, Skolnick P, editors. Current protocols in neuroscience. New York: John Wiley. p 1-23.
25. June HL, Eiler WLA. 2007. Dopaminergic and GABAergic regulation of alcohol-motivated behaviors: Novel neuroanatomical substrates. In: Sibley DR, Hanin I, Kuhar M, Skolnick P, editors. Handbook of contemporary neuropharmacology. Hoboken: John Wiley. p 1-72.
26. June HL, Harvey SC, Foster KL, McKay PF, Cummings R, Garcia M, Mason D, Grey C, McCane S, Williams LS, Johnson TB, He X, Rock S, Cook JM. 2001. GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: An extended ethanol reward circuitry. J Neurosci 21:2166-2177. (Pubitemid 32221399)
27. Koob GF. 2000. Neurobiology of addiction: Toward the development of new therapies. Ann N Y Acad Sci 909:170-185. (Pubitemid 30462039)
28. Koob GF. 2004. A role for GABA mechanisms in the motivational effects of alcohol. Biochem Pharmacol 68:1515-1525.
29. Koob GF, Bloom FE. 1988. Cellular and molecular mechanisms of drug dependence. Science 242:715-723. (Pubitemid 18276493)
30. Koob GF, Le Moal M. 2005. Plasticity of reward neurocircuitry and the "dark side" of drug addiction. Nat Neurosci. 8:1442-1444.
31. Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytia P, Merlo-Pich E, Weiss F. 1998. Neurocircuitry targets in ethanol reward and dependence. Alcoholism Clin Exp Res 22:3-9. (Pubitemid 28139190)
32. Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. 1998. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281:1640-1645. (Pubitemid 28435572)
33. Krause JE, Chirgwin JM, Carter MS, Xu ZS, Hershey AD. 1987. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Proc Natl Acad Sci USA 84:881-885.
34. Kunkler PE, Hwang BH. 1995. Lower GABA-A receptor binding in the amygdala and hypothalamus of spontaneously hypertensive rats. Brain Res Bull 36:57-61.
35. Kushner MG, Abrams K Borchardt C. 2000. The relationship between anxiety disorders and alcohol use disorders: A review of major perspectives and findings. Clin Psychol Rev 20:149-171.
36. Levita L, Mania I, Rainnie DG. 2003. Subtypes of substance P receptor immunoreactive interneurons in the rat basolateral amygdala. Brain Res 981:41-51. (Pubitemid 37281218)
37. Li TK, Lumeng L, McBride WJ, Murphy JM, Froehlich JC, Morzorati S. 1998. Pharmacology of alcohol preference in rodents. Adv Alcohol Substance Abuse 7:73-86.
38. Marksteiner J, Kaufmann W, Pfaller K, Sieghart W, Saria A. 1996. Striatal efferents preferentially innervate neurons in the ventral pallidum containing GABAA receptor alpha 1 subunit-like immunoreactivity. Synapse 23:107-114. (Pubitemid 26127245)
39. McBride WJ. 2002. Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. Pharmacol Biochem Behav 71:509-515. (Pubitemid 34117719)
40. McBride WJ, Li TK. 1998. Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12:339-369.
41. Meisch RA, Bell SM, Lemaire GA. 1993. Orally self-administered cocaine in rhesus monkeys: Transition from negative or neutral behavioral effects to positive reinforcing effects. Drug Alcohol Depend 32:143-158. (Pubitemid 23131217)
42. Nakanishi S. 1991. Mammalian tachykinin receptors. Annu Rev Neurosci 14:123-136.
43. Nikolaev SV, Bychkov ER, Lebedev AA, Dambinova SA. 2002. The influence of substance P central administration on ethanol intake in rats chronically exposed to alcohol. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 88:907-913.
44. Nikolaev SV, Bychkov ER, Lebedev AA, Dambinova SA. 2003. Mechanisms of the influences of the central administration of substance P on ethanol consumption in chronically alcoholic rats. Neurosci Behav Physiol 33:905-909.
45. Nikolaus S, Huston JP, Hasenohrl RU. 1999a. The neurokinin-1 receptor antagonist WIN51,708 attenuates the anxiolytic-like effects of ventralpallidal substance P injection. NeuroReport 10:2293-2296. (Pubitemid 29367926)
46. Nikolaus S, Huston JP, Hasenohrl RU. 1999b. Reinforcing effects of neurokinin substance P in the ventral pallidum: Mediation by the tachykinin NK1 receptor. Eur J Pharmacol 370:93-99. (Pubitemid 29185094)
47. Nikolaus S, Huston JP, Hasenohrl RU. 2000. Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P. Neurosci Lett 283:37-40. (Pubitemid 30145491)
48. Pandey SC, Chartoff EH, Carlezon WA, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT. 2005a. CREB gene transcription factors: Role in molecular mechanisms of alcohol and drug addiction. Alcoholism: Clin Exp Res 29:176-184. (Pubitemid 40250506)
49. Pandey SC, Zhang H, Roy A, Xu T. 2005b. Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J Clin Invest 115:2762-2773. (Pubitemid 41434403)
50. Pandey SC, Zhang H, Roy A, Xu TJ. 2005c. Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J Clin Invest 115:2765-2773.
51. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. San Diego: Academic Press.
52. Pompei P, Angeletti S, Ciccocioppo R, Colombo G, Gessa GL, Massi M. 1998. Preprotachykinin-A gene expression in the forebrain of Sardinian alcohol-preferring and -nonpreferring rats. Mol Brain Res 56:277-280. (Pubitemid 28271685)
53. Primeaux SD, Wilson SP, Bray GA, York DA, Wilson MA. 2006. Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats. Alcoholism: Clin Exp Res 30:791-801.
54. Richter RM, Zorrilla EP, Basso AM, Koob GF, Weiss F. 2000. Altered amygdaloid CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: A microdialysis and behavioral study. Alcoholism: Clin Exp Res 24:1765-1772. (Pubitemid 32001846)
55. Schuckit MA, Hesselbrock V. 1994. Alcohol dependence and anxiety disorders: What is the relationship? Am J Psychiatry 151:1723-1734.
56. Slawecki CJ, Jimenez-Vasquez P, Mathe AA, Ehlers CL. 2001. Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats. J Stud Alcohol 62:736-740. (Pubitemid 34118926)
57. Stewart RB, Gatto GJ, Lumeng L, Li TK, Murphy JM. 1993. Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10:1-10. (Pubitemid 23062791)
58. Sun N, Cassell MD. 1993. Intrinsic GABAergic neurons in the rat central extended amygdala. J Comp Neurol 330:381-404. (Pubitemid 23095334)
59. Sun N, Yi H, Cassell MD. 1994. Evidence for a GABAergic interface between cortical afferents and brainstem projection neurons in the rat central extended amygdala. J Comp Neurol 340:43-64. (Pubitemid 24036458)
60. Suzuki R, Lumeng L, McBride WJ, Li TK, Hwang BH. 2004. Reduced neuropeptide Y mRNA expression in the central nucleus of the amygdala of alcohol-preferring (P) rats: Its potential involvement in alcohol preference and anxiety. Brain Res 1014:251-254. (Pubitemid 38798471)
61. Teixeira RM, Santos AR, Ribeiro SJ, Calixto JB, Rae GA, De Lima TC. 1996. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur J Pharmacol 311(1):7-14.
62. Veinante P, Stoeckel ME, Freund-Mercier MJ. 1997. GABA- and peptide-immunoreactivities co-localize in the rat central extended amygdala. NeuroReport 8:2985-2989. (Pubitemid 27394831)
63. Yilmazer-Hanke DM, Faber-Zuschratter H, Linke R, Schwegler H. 2002. Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration-related anxiety in inbred Roman high- and low-avoidance rats. Eur J Neurosci 15:1206-1218. (Pubitemid 35463621)
64. Young WS III, Bonner TI, Brann MR. 1986. Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. Proc Natl Acad Sci USA 83:9827-9831.