Editorial: Validating serologic biomarkers of brain injury for cardiac arrest research

Pediatric Critical Care Medicine

Volumn 10, Issue 4, 2009, Pages 529-530

  Tasker, Robert C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Biomarker; Brain; Cardiac arrest; Neuron specifc enolase; Outcome; S 100B

Indexed keywords

BIOLOGICAL MARKER; NEURON SPECIFIC ENOLASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN S100B; ENOLASE; NERVE GROWTH FACTOR; PROTEIN S 100; S 100 CALCIUM BINDING PROTEIN BETA SUBUNIT; S-100 CALCIUM-BINDING PROTEIN BETA SUBUNIT;

BRAIN INJURY; CLINICAL EXAMINATION; EDITORIAL; HEART ARREST; HUMAN; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; RESUSCITATION; SEROLOGY; BLOOD; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; INTENSIVE CARE UNIT; NOTE; PROGNOSIS; REPRODUCIBILITY; TIME;

BIOLOGICAL MARKERS; CARDIOPULMONARY RESUSCITATION; CENTRAL NERVOUS SYSTEM DISEASES; CHILD; HEART ARREST; HUMANS; INTENSIVE CARE UNITS, PEDIATRIC; NERVE GROWTH FACTORS; PHOSPHOPYRUVATE HYDRATASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROGNOSIS; REPRODUCIBILITY OF RESULTS; S100 PROTEINS; TIME FACTORS;

EID: 70349288397     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181a0e102     Document Type: Editorial

References (15)

1. Olney JW: Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969; 164: 719-721
2. Rothman S: Synaptic release of excitatory amino acid neurotransmitter mediates an-oxic neuronal death. J Neurosci 1985; 4:1884-1891
3. Smith ML, Auer RN, Siesjo BK: The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain isch-emia. Acta Neuropathol 1984; 64:319-332
4. Choi DW, Maulucci-Gedde M, Kriegstein AR: Glutamate neurotoxicity in cortical cell culture. J Neurosci 1987; 7:357-368
5. Koh JY, Choi DW: Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydroge-nase efflux assay. J Neurosci Methods 1987; 20:83-90
6. Hickey RW, Nadkarni V: Future directions in cardiocerebral resuscitation. Pediatr Clin North Am 2008; 55:1051-1064
7. Tasker RC: Extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest: Lessons from acute neurotoxicity. Pediatr Crit Care Med 2009; 10:525-527
8. Haque IU, Udassi JP, Zaritsky AL: Outcome following cardiopulmonary arrest. Pediatr Clin North Am 2008; 55:969-987
9. Kochanek PM, Berger RP, Bayir H, et al.: Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: Diagnosis, prognosis, probing mechanisms, and therapeutic decision making. Curr Opin Crit Care 2008; 14:135-141
10. Topjian AA, Lin R, Morris MC, et al.: Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest. Pediatr Crit Care Med 2009; 10: 479-490
11. Geraghty MC, Torbey MT: Neuroimaging and serologic markers of neurologic injury after cardiac arrest. Neurol Clin 2006; 24: 107-121
12. Ekmektzoglou KA, Xanthos T, Papadimitriou L: Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation. Resuscitation 2007; 75: 219-228
13. Tasker RC: Biochemical markers of brain injury: Can they point to a diagnosis? Pediatr Crit Care Med 2006; 7:608-610
14. Haqqani AS, Hutchison JS, Ward R, et al.: Biomarkers and diagnosis: Protein biomar-kers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS. J Neurotrauma 2007; 24: 54-74
15. Los Arcos M, Rey C, Concha A, et al.: Acute-phase reactants after paediatric cardiac arrest. Procalcitonin as marker of immediate outcome. BMC Pediatr 2008; 8:18