Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation

Resuscitation

Volumn 75, Issue 2, 2007, Pages 219-228

  Ekmektzoglou, Konstantinos A ^a   Xanthos, Theodoros ^a   Papadimitriou, Lila ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Cardiac arrest; IL 8; Neurological outcome; NSE; S 100

Indexed keywords

BIOCHEMICAL MARKER; INTERLEUKIN 8; NEURON SPECIFIC ENOLASE; PROTEIN S 100;

BRAIN FUNCTION; HEART ARREST; HUMAN; NEUROIMAGING; NEUROLOGIC EXAMINATION; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RESUSCITATION; REVIEW; SENSITIVITY AND SPECIFICITY;

BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CARDIOPULMONARY RESUSCITATION; HEART ARREST; HUMANS; INTERLEUKIN-8; PHOSPHOPYRUVATE HYDRATASE; S100 PROTEINS; TREATMENT OUTCOME;

EID: 35348829065     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2007.03.016     Document Type: Review

References (83)

1. Sans S., Kesteloot H., and Kromhout D. The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 18 (1997) 1231-1248
2. American Heart Association. Heart disease and stroke statistics. Dallas, TX: American Heart Association; 2005 [update].
3. Edgren E., Kelsey S., Sulton K., and Safar P. The presenting ECG pattern in survivors of cardiac arrest and its relation to subsequent long-term survival. Brain Resuscitation Clinical Trial I Study Group. Acta Anaesthesiol Scand 33 (1989) 265-271
4. Ewy G.A. Cardiopulmonary resuscitation: strengthening the links in the chain of survival. N Engl J Med 342 (2000) 1599-1601
5. Berek K., Lechleitner P., Luef G., et al. Early determination of neurological outcome after prehospital cardiopulmonary resuscitation. Stroke 26 (1995) 543-549
6. Jorgensen E.O., and Holm S. The course of circulatory and cerebral recovery after circulatory arrest: influence of pre-arrest, arrest and post-arrest factors. Resuscitation 42 (1999) 173-182
7. Martens P., Haymerle A., Sterz F., Vanhaute O., and Calle P. Limitation of life support after resuscitation from cardiac arrest: practice in Belgium and Austria. Resuscitation 35 (1997) 123-128
8. Jacobs P., and Noseworthy T.W. National estimates of intensive care utilization nd costs: Canada and the United States. Crit Care Med 18 (1990) 282-1286
9. Bassetti C., Bomio F., Mathis J., and Hess C.W. Early prognosis in coma after cardiac arrest: a prospective clinical, electrophysiological, and biochemical study of 60 patients. J Neurol Neurosurg Psychiatry 61 (1996) 610-615
10. Levy D.E., Caronna J.J., Singer B.H., Lapinski R.H., Frydman H., and Plum F. Predicting outcome from hypoxic-ischemic coma. JAMA 253 (1985) 1420-1426
11. Madl C., Grimm G., Kramer L., et al. Early prediction of individual outcome after cardiopulmonary resuscitation. Lancet 341 (1993) 855-858
12. Mullie A., Verstringe P., Buylaert W., et al. Predictive value of Glasgow Coma Score for awakening after out-of-hospital cardiac arrest. Cerebral Resuscitation Study Group of the Belgian Society for Intensive Care. Lancet 1 (1988) 137-140
13. Saltuari L., and Marosi M. Coma after cardiac arrest: will he recover all right?. Lancet 343 (1994) 1052-1053
14. Krumholz A., Stern B.J., and Weiss H.D. Outcome from coma after cardiopulmonary resuscitation: relation to seizures and myoclonus. Neurology 38 (1988) 401-406
15. Edgren E., Hedstrand U., Kelsey S., Sutton-Tyrell K., and Safar P. Assessment of neurological prognosis in comatose survivors of cardiac arrest. BRCT I Study Group. Lancet 343 (1994) 1055-1059
16. Bertini G., Margheri M., Giglioli C., et al. Prognostic significance of early clinical manifestations in postanoxic coma: a retrospective study of 58 patients resuscitated after prehospital cardiac arrest. Crit Care Med 17 (1989) 627-633
17. Niskanen M., Kari A., Nikki P., et al. Acute physiology and chronic health evaluation (APACHE II) and Glasgow coma scores as predictors of outcome from intensive care after cardiac arrest. Crit Care Med 19 (1991) 1465-1473
18. Scollo L.G., and Bassetti C. Prognostic value of EEG in post-anoxic coma after cardiac arrest. Eur Neurol 26 (1987) 161-170
19. Sonnet M.L., Perrot D., Floret D., et al. Early somatosensory (SEP) and auditory (AEP) evoked potentials in anoxic coma: prognostic value. Neurophysiol Clin 23 (1993) 227-236
20. Zandbergen E.G., de Haan R.J., Stoutenbeek C.P., Koelman J.H., and Hijdra A. Systematic review of early prediction of poor outcome in anoxic-ischemic coma. Lancet 352 (1998) 1808-1812
21. De Giorgio C., Rabinowicz A.L., and Gott P.S. Predictive value of P300 event-related potentials compared with EEG and somatosensory evoked potentials in non-traumatic coma. Acta Neurol Scand 37 (1993) 423-427
22. Guerit J.M., Tourtchaninoff M., Soveges L., and Mahieu P. The prognostic value of three-modality evoked potentials (TMEPs) in anoxic and traumatic comas. Neurophysiol Clin 23 (1993) 209-226
23. Morimoto Y., Kemmotsu O., Kitami K., Matsubara I., and Tedo I. Acute brain swelling after out-of-hospital cardiac arrest: pathogenesis and outcome. Crit Care Med 21 (1993) 104-110
24. Fujioka M., Okuchi K., Sakaki T., Hiramatsu K., Miyamoto S., and Iwasaki S. Specific changes in human brain following reperfusion after cardiac arrest. Stroke 25 (1994) 2091-2095
25. Adams J.E., Bodor G.S., Davila-Roman V.G., et al. Cardiac troponin. I. A marker with high specificity for cardiac injury. Circulation 88 (1993) 101-106
26. Brain Resuscitation Clinical Trial I Study Group. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med 314 (1986) 397-403
27. Brain Resuscitation Clinical Trial II Study Group. A randomized clinical study of a calcium entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. N Engl J Med 324 (1991) 1225-1231
28. Welbourn C.R., Goldman G., Paterson I.S., Valeri C.R., Shepro D., and Hechtman H.B. Pathophysiology of ischaemia reperfusion injury: central role of neutrophil. Br J Surg 78 (1991) 651-655
29. Roine R.O., Raininko R., Erkinjuntti T., Ylikoski A., and Kaste M. Magnetic resonance imaging findings associated with cardiac arrest. Stroke 24 (1993) 1005-1014
30. Auer R.N., and Benveniste H. Hypoxia and related conditions. In: Graham D.I., and Lantos F.L. (Eds). Greenfield's neuropathology (1997), Edward Arnold, London, UK 263-314
31. Sekido N., Mukaida N., Harada A., Nakanishi I., Watanabe Y., and Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 365 (1993) 654-657
32. Kitagawa K., Matsumoto M., Oda T., et al. Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death. Neuroscience 35 (1990) 551-558
33. Gando S., Nanzaki S., Morimoto Y., Kobayashi S., and Kemmotsu O. Alterations of soluble L- and P-selectins during cardiac arrest and CPR. Intensive Care Med 25 (1999) 588-593
34. Goe M.R., and Massey T.H. Assessment of neurologic damage: creatine kinase-BB assay after cardiac arrest. Heart Lung 17 (1988) 247-253
35. Karkela J., Pasanen M., Kaukinen S., Morsky P., and Harmoinen A. Evaluation of hypoxic brain injury with spinal fluid enzymes, lactate, and pyruvate. Crit Care Med 20 (1992) 378-386
36. Kjekshus J., and Vaagenes P. Cerebrospinal fluid creatine kinase isoenzyme BB levels do not predict the clinical outcome inpatients unconscious following cardiac resuscitation. Clin Cardiol 11 (1988) 10-13
37. Roine R.O., Somer H., Kaste M., Viinikka L., and Karonen S.L. Neurological outcome after out-of-hospital cardiac arrest. Prediction by cerebrospinal fluid enzyme analysis. Arch Neurol 46 (1989) 753-756
38. Pahlman S., Esscher T., Bergvall P., and Odelstad L. Purification and characterization of human neuron-specific enolase: radioimmunoassay development. Tumour Biol 5 (1984) 127-139
39. Johnsson P., Blomquist S., Luhrs C., et al. Neuron-specific enolase increases in plasma during and immediately after extracorporeal circulation. Ann Thorac Surg 69 (2000) 750-754
40. Ramont L., Thoannes H., Volondat A., Chastang F., Millet M.C., and Maquart F.X. Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice. Clin Chem Lab Med 43 (2005) 1215-1217
41. Missler U., Wiesmann M., Friedrich C., and Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 28 (1997) 1956-1960
42. Fassbender K., Schmidt R., Schreiner A., et al. Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke. J Neurol Sci 148 (1997) 101-105
43. Martens P. Serum neuron-specific enolase as a prognostic marker for irreversible brain damage in comatose cardiac arrest survivors. Acad Emerg Med 3 (1996) 126-131
44. Rech T.H., Vieira S.R., Nagel F., Brauner J.S., and Scalco R. Serum neuron-specific enolase as early predictor of outcome after in-hospital cardiac arrest: a cohort study. Crit Care 10 (2006) R133
45. Pfeifer R., Borner A., Krack A., Sigusch H., Surber R., and Figulla H. Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale. Resuscitation 65 (2005) 49-55
46. Zingler V.C., Krumm B., Bertsch T., Fassbender K., and Pohlmann-Eden B. Early prediction of neurological outcome after cardiopulmonary resuscitation: a multimodal approach combining neurobiochemical and electrophysiological investigations may provide high prognostic certainty in patients after cardiac arrest. Eur Neurol 49 (2003) 79-84
47. Schoerkhuber W., Kittler H., Sterz F., et al. Time course of serum neuron-specific enolase: a predictor of neurological outcome in patients resuscitated from cardiac arrest. Stroke 30 (1999) 1598-1603
48. Fogel W., Krieger D., Veith M., et al. Serum neuron-specific enolase as early predictor of outcome after cardiac arrest. Crit Care Med 25 (1997) 1133-1138
49. Schaarschmidt H., Prange H.W., and Reiber H. Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke 25 (1994) 558-565
50. Bottiger B.W., Mobes S., Glatzer R., et al. Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation 103 (2001) 2694-2698
51. Schafer B.W., and Heizmann C.W. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 21 (1996) 134-140
52. Donato R. Functional roles of S 100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta 1450 (1999) 191-231
53. Isobe T., Takahasi K., and Okuyama T. S-100 A0 (alpha alpha) protein is present in neurons of central and peripheral neurons system. J Neurochem 43 (1984) 1494-1496
54. Kligman D., and Hill D.C. The S100 protein family. Trends Biochem Sci 11 (1988) 437-443
55. Kim J.S., Yaon S.S., Kim Y.H., and Ryu J.S. Serial measurements of interleukin-6 transforming growth factor-b, and S-100 protein inpatients with acute stroke. Stroke 27 (1996) 1553-1557
56. Kilminster S., Treasure T., McMillan T., and Holt D.W. Neuropsychological change and S-100 protein release in 130 unselected patients undergoing cardiac surgery. Stroke 30 (1999) 1869-1874
57. Herrmann M., Ebert A.D., Galazky I., Wunderlich M.T., Kunz W.S., and Huth C. Neurobehavioral outcome prediction after cardiac surgery: role of neurobiochemical markers of damage to neuronal and glial brain tissue. Stroke 31 (2000) 645-650
58. Westaby S., Johnsson P., Parry A.J., et al. Serum S 100 protein: a potential marker for cerebral events during cardiopulmonary bypass. Ann Thorac Surg 61 (1996) 88-92
59. Snyder-Ramos S.A., Gruhlke T., Bauer H., et al. Cerebral and extracerebral release of protein S100B in cardiac surgical patients. Anaesthesia 59 (2004) 344-349
60. Hachimi-Idrissi S., Van der Auwera M., Schiettecatte J., Ebinger G., Michotte Y., and Huyghens L. S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest. Resuscitation 53 (2002) 251-257
61. Mussack T., Biberthaler P., Kanz K., et al. Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit Care Med 30 (2002) 2669-2674
62. Rosen H., Sunnerhagen K.S., Herlitz J., Blomstrand C., and Rosengren L. Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. Resuscitation 49 (2001) 183-191
63. Mussack T., Biberthaler P., Kanz K.G., Wiedemann E., Gippner-Steppert C., and Jochum M. S-100b, sE-selectin, and sP-selectin for evaluation of hypoxic brain damage in patients after cardiopulmonary resuscitation: pilot study. World J Surg 25 (2001) 539-543 [discussion 544]
64. Martens P., Raabe A., and Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke 29 (1998) 2363-2366
65. Metinko A.P., Kunkel S.L., Standiford T.J., and Strieter R.M. Anoxia-hyperoxia induces monocyte-derived interleukin-8. J Clin Invest 90 (1992) 791-798
66. Stanimirovic D., and Satoh K. Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation. Brain Pathol 10 (2000) 113-126
67. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 320 (1989) 365-376
68. Bone R.C. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med 24 (1996) 163-172
69. Ito T., Saitoh D., Fukuzuka K., et al. Significance of elevated serum interleukin-8 in patients resuscitated after cardiopulmonary arrest. Resuscitation 51 (2001) 47-53
70. Shyu K.G., Chang H., Lin C.C., Huang F.Y., and Hung C.R. Concentrations of serum interleukin-8 after successful cardiopulmonary resuscitation in patients with cardiopulmonary arrest. Am Heart J 134 (1997) 551-556
71. Booth C.M., Boone R.H., Tomlinson G., and Detsky A.S. Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest. JAMA 291 (2004) 870-879
72. Logi F., Fischer C., Murri L., and Mauguiere F. The prognostic value of evoked responses from primary somatosensory and auditory cortex in comatose patients. Clin Neurophysiol 114 (2003) 1615-1627
73. Fischer C., Luaute J., Adeleine P., and Morlet D. Predictive value of sensory and cognitive evoked potentials for awakening from coma. Neurology 63 (2004) 669-673
74. Zandbergen E.G., de Haan R.J., and Hijdra A. Systematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage. Intensive Care Med 27 (2001) 1661-1667
75. Tirschwell D.L., Longstreth Jr. W.T., Rauch-Matthews M.E., et al. Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest. Neurology 48 (1997) 352-357
76. Vaagenes P., Mullie A., Fodstad D.T., Abramson N., and Safar P. The use of cytosolic enzyme increase in cerebrospinal fluid of patients resuscitated after cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. Am J Emerg Med 12 (1994) 621-624
77. Meynaar I.A., Oudemans-van Straaten H.M., van der Wetering J., et al. Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study. Intensive Care Med 29 (2003) 189-195
78. Zandbergen E.G., Hijdra A., Koelman J.H., et al. PROPAC Study Group. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology 66 (2006) 62-68
79. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346 (2002) 557-563
80. Safar P.J., and Kochanek P.M. Therapeutic hypothermia after cardiac arrest. N Engl J Med 346 (2002) 612-613
81. Tiainen M., Roine R.O., Pettila V., and Takkunen O. Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia. Stroke 34 (2003) 2881-2886
82. Tiainen M., Kovala T.T., Takkunen O.S., and Roine R.O. Somatosensory and brainstem auditory evoked potentials in cardiac arrest patients treated with hypothermia. Crit Care Med 33 (2005) 1736-1740
83. Tirschwell D. Optimizing neurologic prognosis after cardiac arrest. Crit Care 10 (2006) 171 [Epub ahead of print]