Protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS

Journal of Neurotrauma

Volumn 24, Issue 1, 2007, Pages 54-74

  Haqqani, Arsalan S ^a   Hutchison, James S ^b   Ward, Roxanne ^c   Stanimirovic, Danica B ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

Proteomics; S100 ; Serum biomarkers; Traumatic head injury

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; IMMUNOGLOBULIN; PROTEIN S100B; OROSOMUCOID; PROTEIN S 100; RADIOISOTOPE;

ADOLESCENT; AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDY; FEMALE; HOSPITAL ADMISSION; HUMAN; INJURY SEVERITY; INTENSIVE CARE UNIT; ISOTOPE CODED AFFINITY TAG; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRESCHOOL CHILD; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEOMICS; TRAUMATIC BRAIN INJURY; BRAIN INJURY; CEREBROSPINAL FLUID; CHILD; GLASGOW COMA SCALE; INFANT; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN DATABASE;

ADOLESCENT; BIOLOGICAL MARKERS; BRAIN INJURIES; CEREBROSPINAL FLUID PROTEINS; CHILD; CHILD, PRESCHOOL; DATABASES, PROTEIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLASGOW COMA SCALE; HUMANS; INFANT; MALE; OROSOMUCOID; PROTEOMICS; RADIOISOTOPES; S100 PROTEINS;

EID: 33846798507     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.0079     Document Type: Article

References (38)

1. ALAIYA, A., AL MOHANNA, M., and LINDER, S. (2005). Clinical cancer proteomics: promises and pitfalls. J. Proteome. Res. 4, 1213-1222.
2. BANDYOPADHYAY, S., HENNES, H., GORELICK, M.H., WELLS, R.G., and WALSH-KELLY, C.M. (2005). Serum neuron-specific enolase as a predictor of short-term outcome in children with closed traumatic brain injury. Acad. Emerg. Med. 12, 732-738.
3. BERGER, R.P, DULANI, T., ADELSON, P.D., LEVENTHAL, J.M., RICHICHI, R., and KOCHANEK, P.M. (2006). Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool. Pediatrics 117, 325-332.
4. BERGER, R.P., PIERCE, M.C., WISNIEWSKI, S.R., ADELSON, P.D., and KOCHANEK, P.M. (2002). Serum S100B concentrations are increased after closed head injury in children: a preliminary study. J. Neurotrauma 19, 1405-1409.
5. COOPER, E.H. (1994). Neuron-specific enolase. Int. J. Biol. Markers 9, 205-210.
6. DELAHUNTY, C., and YATES, J.R., III (2005). Protein identification using 2D-LC-MS/MS. Methods 35, 248-255.
7. GABBITA, S.P., SCHEFF, S.W., MENARD, R.M, ROBERTS, K., FUGACCIA, I., and ZEMLAN, F.P. (2005). Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury. J. Neurotrauma 22, 83-94.
8. GAZZOLO, D., MICHETTI, F., BRUSCHETTINI, M., et al. (2003). Pediatric concentrations of S100B protein in blood: age- and sex-related changes. Clin. Chem. 49, 967-970.
9. HAQQANI, A.S., NESIC, M., PRESTON, E., BAUMANN, E., KELLY, J., and STANIMIROVIC, D. (2005). Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS. FASEB J. 19, 1809-1821.
10. HASKINS, W.E., KOBEISSY, F.H., WOLPER, R.A., et al. (2005). Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry. J. Neurotrauma 22, 629-644.
11. INGEBRIGTSEN, T., and ROMNER, B. (2003). Biochemical serum markers for brain damage: a short review with emphasis on clinical utility in mild head injury. Restor. Neurol. Neurosci. 21, 171-176.
12. JENKINS, L.W., PETERS, G.W., DIXON, C.E., et al. (2002). Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats. J. Neurotrauma 19, 715-740.
13. KAPURAL, M., KRIZANAC-BENGEZ, L., BARNETT, G., et al. (2002). Serum S-100beta as a possible marker of blood-brain barrier disruption. Brain Res. 940, 102-104.
14. KONIG, R., BALDESSARI, D., POLLET, N., NIEHRS, C., and EILS, R. (2004). Reliability of gene expression ratios for cDNA microarrays in multiconditional experiments with a reference design. Nucleic Acids Res. 32, e29.
15. LEVITON, A., and DAMMANN, O. (2002). Brain damage markers in children. Neurobiological and clinical aspects. Acta Paediatr, 91, 9-13.
16. MARCHI, N., CAVAGLIA, M., FAZIO, V., BHUDIA, S., HALLENE, K., and JANIGRO, D. (2004). Peripheral markers of blood-brain barrier damage. Clin. Chim. Acta 342, 1-12.
17. MARCHI, N., FAZIO, V., CUCULLO, L., et al. (2003). Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption. J. Neurosci. 23, 1949-1955.
18. MATSUMOTO, H., NAGASAKA, T., HATTORI, A., et al. (2001). Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. Eur. J. Biochem. 268, 3259-3266.
19. McCRACKEN, E., HUNTER, A.J., PATEL, S., GRAHAM, D.I., and DEWAR, D. (1999). Calpain activation and cytoskeletal protein breakdown in the corpus callosum of head-injured patients. J. Neurotrauma 16, 749-761.
20. MOHAMMED, M.Q., ABRAHA, H.D., SHERWOOD, R.A., MACRAE, K., and RETSAS, S. (2001). Serum S100beta protein as a marker of disease activity in patients with malignant melanoma. Med. Oncol. 18, 109-120.
21. OLSSON, A., CSAJBOK, L., OST, M., et al. (2004). Marked increase of beta-amyloid(1-42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury. J. Neurol. 251, 870-876.
22. OMENN, G.S., STATES, D.J., ADAMSKI, M., et al. (2005). Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 5, 3226-3245.
23. PELSERS, M.M., and GLATZ, J.F. (2005). Detection of brain injury by fatty acid-binding proteins. Clin. Chem. Lab. Med 43, 802-809.
24. PINEDA, J.A., WANG, K.K., and HAYES, R.L. (2004). Biomarkers of proteolytic damage following traumatic brain injury. Brain Pathol. 14, 202-209.
25. PLEINES, U.E., MORGANTI-KOSSMANN, M.C., RANCAN, M., JOLLER, H., TRENTZ, O., and KOSSMANN, T. (2001). S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J. Neurotrauma 18, 491-498.
26. POLLACK, M.M., PATEL, K.M., and RUTTIMANN, U.E. (1996). PRISM III: an updated Pediatric Risk of Mortality score. Crit. Care Med. 24, 743-752.
27. RAABE, A., KOPETSCH, O., WOSZCZYK, A., et al. (2003). Serum S-100B protein as a molecular marker in severe traumatic brain injury. Restor. Neurol. Neurosci. 21, 159-169.
28. RINGGER, N.C., O'STEEN, B.E., BRABHAM, J.G., et al. (2004). A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels. J. Neurotrauma 21, 1443-1456,
29. ROTHERMUNDT, M., PETERS, M., PREHN, J.H., and AROLT, V. (2003), S100B in brain damage and neurodegeneration. Microsc. Res. Tech. 60, 614-632.
30. SHAW, G., YANG, C., ELLIS, R., et al. (2005). Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury. Biochem. Biophys. Res. Commun. 336, 1268-1277.
31. SIMAN, R., McINTOSH, T.K., SOLTESZ, K.M., CHEN, Z., NEUMAR, R.W., and ROBERTS, V.L. (2004). Proteins released from degenerating neurons are surrogate markers for acute brain damage. Neurobiol, Dis. 16, 311-320.
32. SPINELLA, P.C., DOMINGUEZ, T., DROTT, H.R., et al. (2003). S-100beta protein-serum levels in healthy children and its association with outcome in pediatric traumatic brain injury. Crit. Care Med. 31, 939-945.
33. TANG, Y., LU, A., ARONOW, B.J., WAGNER, K.R., and SHARP, F.R. (2002). Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur. J. Neurosci. 15, 1937-1952.
34. TANG, Y., XU, H., DU, X., et al. (2006). Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J. Cereb. Blood Flow Metab. 26, 1089-1102. doi: 10.1038/sj.jcbfm.9600264.
35. VEENSTRA, T.D., PRIETO, D.A., and CONRADS, T.P. (2004). Proteomic patterns for early cancer detection. Drug Discov. Today 9, 889-897.
36. VOGELBAUM, M.A., MASARYK, T., MAZZONE, P., et al. (2005). S100beta as a predictor of brain metastases: brain versus cerebrovascular damage. Cancer 104, 817-824.
37. ZHAO, Q., WANG, J., LEVICHKIN, I.V., STASINOPOULOS, S., RYAN, M.T., and HOOGENRAAD, N.J. (2002). A mitochondrial specific stress response in mammalian cells. EMBO J. 21, 4411-4419.
38. ZHONG, Y., TAKEMOTO, M., FUKUDA, T., et al. (2004). Identification of the genes that are expressed in the upper layers of the neocortex. Cereb. Cortex 14, 1144-1152.