Gap junction inhibitors modulate S100B secretion in astrocyte cultures and acute hippocampal slices

Journal of Neuroscience Research

Volumn 87, Issue 11, 2009, Pages 2439-2446

  Leite, Marina Concli ^a   Galland, Fabiana ^a   De Souza, Daniela F ^a   Guerra, Maria Cristina ^a   Bobermin, Larissa ^a   Biasibetti, Regina ^a   Gottfried, Carmem ^a   Gonçalves, Carlos Alberto ^a  

^a Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

Author keywords

Carbenoxolone; Endothelin 1; Flufenamic acid; Gap junction; S100B

Indexed keywords

CARBENOXOLONE; ENDOTHELIN 1; PROTEIN S100B; CENTRAL NERVOUS SYSTEM AGENTS; DRUG DERIVATIVE; FLUFENAMIC ACID; GLYCYRRHIZIC ACID; HALOTHANE; NERVE GROWTH FACTOR; OCTANOL; PROTEIN S 100; S 100 CALCIUM BINDING PROTEIN BETA SUBUNIT; S-100 CALCIUM-BINDING PROTEIN BETA SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GAP JUNCTION; HIPPOCAMPUS; NERVE CELL CULTURE; NEURITE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; ANIMAL; CELL JUNCTION; DRUG EFFECT; HUMAN; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; SECRETION; TIME; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ASTROCYTES; CARBENOXOLONE; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM AGENTS; ENDOTHELIN-1; FLUFENAMIC ACID; GAP JUNCTIONS; GLYCYRRHIZIC ACID; HALOTHANE; HIPPOCAMPUS; HUMANS; NERVE GROWTH FACTORS; OCTANOLS; RATS; RATS, WISTAR; S100 PROTEINS; TIME FACTORS;

EID: 70349260854     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22083     Document Type: Article

References (31)

1. 2+ homeostasis and cell death. J Neurochem 70:958-970.
2. Blomstrand F, Giaume C. 2006. Kinetics of endothelin-induced inhibition and glucose permeability of astrocyte gap junctions. J Neurosci Res 83:996-1003.
3. 2+ levels regulate the alternative cell density-dependent secretion of S100B in human glioblastoma cells. J Biol Chem 276:30819-30826.
4. de Souza DF, Leite MC, Quincozes-Santos A, Nardin P, Tortorelli LS, Rigo MM, Gottfried C, Leal RB, Goncalves CA. 2009. S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: likely involvement of MAPK pathway. J Neuroimmunol 206:52-57.
5. Donato R. 2001. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637-668. (Pubitemid 32520962)
6. Elsen FP, Shields EJ, Roe MT, Vandam RJ, Kelty JD. 2008. Carbenoxolone induced depression of rhythmogenesis in the pre-Botzinger complex. BMC Neurosci 9:46.
7. + concentration. J Neurochem 62:489-495.
8. Feoli AM, Leite MC, Tramontina AC, Tramontina F, Posser T, Rodrigues L, Swarowsky A, Quincozes-Santos A, Leal RB, Gottfried C, Perry ML, Goncalves CA. 2008. Developmental changes in content of glial marker proteins in rats exposed to protein malnutrition. Brain Res 1187:33-41. (Pubitemid 350191811)
9. Goncalves D, Karl J, Leite M, Rotta L, Salbego C, Rocha E, Wofchuk S, Goncalves CA. 2002. High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes. Neuroreport 13:1533-1535. (Pubitemid 34970152)
10. Goncalves CA, Concli Leite M, Nardin P. 2008. Biological and methodological features of the measurement of S100B, a putative marker of brain injury. Clin Biochem 41:755-763.
11. Gottfried C, Cechin SR, Gonzalez MA, Vaccaro TS, Rodnight R. 2003. The influence of the extracellular matrix on the morphology and intracellular pH of cultured astrocytes exposed to media lacking bicarbonate. Neuroscience 121:553-562. (Pubitemid 38367496)
12. Kielian T. 2008. Glial connexins and gap junctions in CNS inflammation and disease. J Neurochem 106:1000-1016.
13. Lehmann C, Eisner F, Engele J. 2008. Role of endothelins as mediators of injury-induced alterations of glial glutamate turnover. J Neurosci Res 86:660-667. (Pubitemid 351204480)
14. Leite MC, Galland F, Brolese G, Guerra MC, Bortolotto JW, Freitas R, Almeida LM, Gottfried C, Goncalves CA. 2008. A simple, sensitive and widely applicable ELISA for S100B: methodological features of the measurement of this glial protein. J Neurosci Methods 169:93-99.
15. Liu Y, Peterson DA, Kimura H, Schubert D. 1997. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J Neurochem 69:581-593. (Pubitemid 27327958)
16. Marenholz I, Heizmann CW, Fritz G. 2004. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun 322:1111-1122. (Pubitemid 39164640)
17. +. Neurochem Res [Epub ahead of print] doi 10.1007/s11064-009-9949-0.
18. Nodin C, Nilsson M, Blomstrand F. 2005. Gap junction blockage limits intercellular spreading of astrocytic apoptosis induced by metabolic depression. J Neurochem 94:1111-1123. (Pubitemid 41170597)
19. Ozog MA, Siushansian R, Naus CC. 2002. Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures. J Neuropathol Exp Neurol 61:132-141. (Pubitemid 34127097)
20. Pinto SS, Gottfried C, Mendez A, Goncalves D, Karl J, Goncalves CA, Wofchuk S, Rodnight R. 2000. Immunocontent and secretion of S100B in astrocyte cultures from different brain regions in relation to morphology. FEBS Lett 486:203-207.
21. Rouach N, Avignone E, Meme W, Koulakoff A, Venance L, Blomstrand F, Giaume C. 2002. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell 94:457-475. (Pubitemid 36113697)
22. Rozental R, Giaume C, Spray DC. 2000. Gap junctions in the nervous system. Brain Res Brain Res Rev 32:11-15.
23. Saez JC, Contreras JE, Bukauskas FF, Retamal MA, Bennett MV. 2003. Gap junction hemichannels in astrocytes of the CNS. Acta Physiol Scand 179:9-22.
24. Salameh A, Dhein S. 2005. Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer? Biochim Biophys Acta 1719:36-58.
25. Shihara M, Hirooka Y, Hori N, Matsuo I, Tagawa T, Suzuki S, Akaike N, Takeshita A. 1998. Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS. Am J Physiol 275(2 Pt 2):R658-R665. (Pubitemid 28390143)
26. Stridh MH, Tranberg M, Weber SG, Blomstrand F, Sandberg M. 2008. Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J Biol Chem 283:10347-10356.
27. Tabernero A, Medina JM, Giaume C. 2006. Glucose metabolism and proliferation in glia: role of astrocytic gap junctions. J Neurochem 99:1049-1061. (Pubitemid 44655272)
28. Tramontina F, Conte S, Goncalves D, Gottfried C, Portela LV, Vinade L, Salbego C, Goncalves CA. 2002. Developmental changes in S100B content in brain tissue, cerebrospinal fluid, and astrocyte cultures of rats. Cell Mol Neurobiol 22:373-378. (Pubitemid 35364894)
29. Van Eldik LJ, Wainwright MS. 2003. The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restor Neurol Neurosci 21:97-108.
30. Van Eldik LJ, Zimmer DB. 1987. Secretion of S-100 from rat C6 glioma cells. Brain Res 436:367-370.
31. + - ATPase inhibiting action]. Yao Xue Xue Bao 31:496-501.