Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy

Journal of Biomedical Optics

Volumn 14, Issue 3, 2009, Pages

  Graf, Benedikt W ^a   Jiang, Zhi ^a   Tu, Haohua ^a   Boppart, Stephen A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

continuum generation; multimodality imaging; multiphoton microscopy; optical coherence microscopy

Indexed keywords

CELL BIOLOGY; CONTINUUM GENERATIONS; FLUORESCENT DYES; FLUORESCENT MARKERS; IN-VIVO; IN-VIVO HUMAN SKIN; INTEGRATED IMAGING; LASER CHARACTERISTICS; LASER SOURCES; MODE-LOCKED; MOUSE-FIBROBLASTS; MULTI-PHOTON MICROSCOPY; MULTIMODALITY IMAGING; NOISE POWER; OPTICAL COHERENCE MICROSCOPY; OPTICAL SECTIONING; SPECTRAL RANGE; TI-SAPPHIRE; WIDE SPECTRAL RANGE; WIDELY TUNABLE;

CELL CULTURE; FLUORESCENCE; IMAGING TECHNIQUES; INTEGRATION; MAMMALS; PHOTONIC CRYSTAL FIBERS; PHOTONIC CRYSTALS; SAPPHIRE; TISSUE; TISSUE ENGINEERING;

MODE-LOCKED FIBER LASERS;

ALUMINUM OXIDE; TITANIUM;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; CYTOLOGY; FIBROBLAST; HISTOLOGY; HUMAN; LASER; METHODOLOGY; MOUSE; MULTIPHOTON MICROSCOPY; OPTICAL COHERENCE TOMOGRAPHY; SKIN; SYSTEM ANALYSIS;

ALUMINUM OXIDE; ANIMALS; CELLS, CULTURED; FIBROBLASTS; HUMANS; LASERS; MICE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; SKIN; SYSTEMS INTEGRATION; TITANIUM; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 70349232455     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3147422     Document Type: Article

References (20)

1. J. A., Izatt, M. R., Hee, G. M., Owen, E. A., Swanson, and J. G., Fujimoto, " Optical coherence microscopy in scattering media, ", Opt. Lett., 19, 590-592 (1994). opl OPLEDP 0146-9592 10.1364/OL.19.000590
2. V. E., Centonze and J. G., White, " Multiphoton excitation provides optical sections from deeper within scattering specimens than confocal imaging, ", Biophys. J., 75, 2015-2024 (1998). bio BIOJAU 0006-3495 10.1016/S0006-3495(98)77643-X
3. A. T., Yeh, B., Kao, W. G., Jung, Z., Chen, J. S., Nelson, and B. J., Tromberg, " Imaging wound healing using optical coherence tomography and multiphoton microscopy in an, in vitro, skin-equivalent tissue model, ", J. Biomed. Opt., 9, 248-253 (2004). jbo JBOPFO 1083-3668 10.1117/1.1648646
4. S., Yazdanfar, Y. Y., Chen, P. T. C., So, and L. H., Laiho, " Multifunctional imaging of endogenous contrast by simultaneous nonlinear and optical coherence microscopy of thick tissues, ", Microsc. Res. Tech., 70, 628-633 (2007). mru MRTEEO 1059-910X 10.1002/jemt.20447
5. S., Tang, C., Sun, T. B., Krasieva, Z., Chen, and B. J., Tromberg, " Imaging subcellular scattering contrast by using combined optical coherence and multiphoton microscopy, ", Opt. Lett., 32, 503-505 (2007). opl OPLEDP 0146-9592 10.1364/OL.32.000503
6. S., Tang, T. B., Krasieva, Z., Chen, G., Tempea, and B. J., Tromberg, " Effect of pulse duration on two-photon excited fluorescence and second harmonic generation in nonlinear optical microscopy, ", J. Biomed. Opt., 22, 020501 (2006). jbo JBOPFO 1083-3668 10.1117/1.2177676
7. U., Morgner, W., Drexler, F. X., Kartner, X. D., Li, C., Pitris, E. P., Ippen, and J. G., Fujimoto, " Spectroscopic optical coherence tomography, ", Opt. Lett., 25, 111-113 (2000). opl OPLEDP 0146-9592 10.1364/OL.25.000111
8. C., Xu, C., Vinegoni, T. S., Ralston, W., Luo, W., Tan, and S. A., Boppart, " Spectroscopic spectral-domain optical coherence microscopy, ", Opt. Lett., 31, 1079-1081 (2006). opl OPLEDP 0146-9592 10.1364/OL.31.001079
9. E., Beaurepaire, L., Moreaux, F., Amblard, and J., Mertz, " Combined scanning optical coherence and two-photon excited fluorescence microscopy, ", Opt. Lett., 24, 969-971 (1999). opl OPLEDP 0146-9592 10.1364/OL.24.000969
10. C., Vinegoni, T., Ralston, W., Tan, W., Luo, D. L., Marks, and S. A., Boppart, " Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy, ", Appl. Phys. Lett., 88, 053901 (2006). apl APPLAB 0003-6951 10.1063/1.2171477
11. S., Tang, T. B., Krasieva, Z., Chen, and B. J., Tromberg, " Combined multiphoton microscopy and optical coherence tomography using a, 12-fs, broadband source, ", J. Biomed. Opt., 11, 020502 (2006). jbo JBOPFO 1083-3668 10.1117/1.2193428
12. C., Joo, K., Kim, and J., de Boer, " Spectral-domain optical coherence phase and multiphoton microscopy, ", Opt. Lett., 32, 623-625 (2007). opl OPLEDP 0146-9592 10.1364/OL.32.000623
13. T. M., Lee, A. L., Oldenburg, S., Sitafalwalla, D. L., Marks, W., Luo, F. J., Toublan, K. S., Suslick, and S. A., Boppart, " Engineered microsphere contrast agents for optical coherence tomography, ", Opt. Lett., 28, 1546-1548 (2003). opl OPLEDP 0146-9592 10.1364/OL.28.001546
14. D. L., Marks, A. L., Oldenburg, J. J., Reynolds, and S. A., Boppart, " Study of an ultrahigh-numerical-aperture fiber continuum generation source for optical coherence tomography, ", Opt. Lett., 27, 2010-2012 (2002). opl OPLEDP 0146-9592 10.1364/OL.27.002010
15. J. K., Ranka, R. S., Windeler, and A. J., Stentz, " Visible continuum generation in air-silica microstructure optical fibers with anomalous dispersion at, 800nm, ", Opt. Lett., 25, 25-27 (2000). opl OPLEDP 0146-9592 10.1364/OL.25.000025
16. G., Humbert, W., Wadsworth, S., Leon-Saval, J., Knight, T., Birks, P. St. J., Russell, M., Lederer, D., Kopf, K., Wiesauer, E., Breuer, and D., Stifter, " Supercontinuum generation system for optical coherence tomography based on tapered photonic crystal fibre, ", Opt. Express, 14, 1596-1603 (2006). 8mi OPEXFF 1094-4087 10.1364/OE.14.001596
17. H., Tu, D. L., Marks, Y. L., Koh, and S. A., Boppart, " Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography, ", Opt. Lett., 32, 2037-2039 (2007). opl OPLEDP 0146-9592 10.1364/OL.32.002037
18. W., Tan, C., Vinegoni, J. J., Norman, T. A., Desai, and S. A., Boppart, " Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs, ", Microsc. Res. Tech., 70, 361-371 (2007). mru MRTEEO 1059-910X 10.1002/jemt.20420
19. C., Xu, W., Zipfel, J. B., Shear, R. M., Williams, and W. W., Webb, " Multiphoton fluorescence excitation: New spectral windows for biological nonlinear microscopy, ", Proc. Natl. Acad. Sci. U.S.A., 93, 10763-10768 (1996). pna PNASA6 0027-8424 10.1073/pnas.93.20.10763
20. K., Konig and I., Riemann, " High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution, ", J. Biomed. Opt., 8, 432-439 (2003). jbo JBOPFO 1083-3668 10.1117/1.1577349