The pathophysiology of chronic graft failure in the cardiac transplant patient

American Journal of Transplantation

Volumn 9, Issue 10, 2009, Pages 2211-2216

  Khan, U A ^a   Williams, S G ^a   Fildes, J E ^a   Shaw, S M ^a  

^a WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

Cardiac allograft vasculopathy; Chronic allograft dysfunction; Chronic allograft rejection; Chronic graft deterioration; Ischemia reperfusion injury

Indexed keywords

CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN A; TACROLIMUS;

ADRENERGIC SYSTEM; BRAIN DEATH; CARDIAC GRAFT REJECTION; CHRONIC DISEASE; CHRONIC KIDNEY DISEASE; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FIBROSIS; GRAFT FAILURE; HEART EDEMA; HEART FAILURE; HEART GRAFT; HEART GRAFT FAILURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART TRANSPLANTATION; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; OPPORTUNISTIC INFECTION; ORGAN DONOR; PATHOPHYSIOLOGY; POSTOPERATIVE CARE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; SECONDARY IMMUNE RESPONSE; SHORT SURVEY; SYMPATHETIC TONE;

GRAFT REJECTION; HEART FAILURE; HEART TRANSPLANTATION; HUMANS;

EID: 70349224481     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02807.x     Document Type: Short Survey

References (33)

1. Taylor DO, Edwards LB, Aurora P et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth official adult heart transplant report-2008. J Heart Lung Transplant 2008 27 : 943 956.
2. Yamani MH, Haji SA, Starling RC et al. Myocardial ischemic-fibrotic injury after human heart transplantation is associated with increased progression of vasculopathy, decreased cellular rejection and poor long-term outcome. J Am Coll Cardiol 2002 39 : 970 977.
3. Wenke K. Management of hyperlipidaemia associated with heart transplantation. Drugs 2004 64 : 1053 1068.
4. Katouzian A, Sathyanarayana S, Baseri B, Konofagou EE, Carlier SG. Challenges in atherosclerotic plaque characterization with intravascular ultrasound (IVUS): From data collection to classification. IEEE Trans Inf Technol Biomed 2008 12 : 315 327.
5. Braith RW, Mills RM Jr., Wilcox CS et al. Fluid homeostasis after heart transplantation: The role of cardiac denervation. J Heart Lung Transplant 1996 15 : 872 880.
6. Kabour A, Henegar JR, Janicki JS. Angiotensin II (AII)-induced myocyte necrosis: Role of the AII receptor. J Cardiovasc Pharmacol 1994 23 : 547 553.
7. Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone. J Mol Cell Cardiol 1994 26 : 809 820.
8. Kuoppala A, Shiota N, Kokkonen JO et al. Down-regulation of cardioprotective bradykinin type-2 receptors in the left ventricle of patients with end-stage heart failure. J Am Coll Cardiol 2002 40 : 119 125.
9. Lee DB. Cyclosporine and the renin-angiotensin axis. Kidney Int 1997 52 : 248 260.
10. Scherrer U, Vissing SF, Morgan BJ et al. Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med 1990 323 : 693 699.
11. Francis GS, Cohn JN, Johnson G, Rector TS, Goldman S, Simon A. Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group. Circulation 1993 87 (6 Suppl VI40 48.
12. Mann DL, Kent RL, Parsons B, Cooper Gt. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 1992 85 : 790 804.
13. Fildes JE, Shaw SM, Yonan N, Williams SG. The immune system and chronic heart failure: Is the heart in control? J Am Coll Cardiol 2009 53 : 1013 1020.
14. Lin L, Kim SC, Wang Y et al. HSP60 in heart failure: Abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 2007 293 : H2238 2247.
15. Baba HA, Schmid C, Wilhelm MJ et al. Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes. Transplantation 1997 64 : 1035 1040.
16. Zolty R, Hynes PJ, Vittorio TJ. Severe left ventricular systolic dysfunction may reverse with renal transplantation: Uremic cardiomyopathy and cardiorenal syndrome. Am J Transplant 2008 8 : 2219 2224.
17. Scharer K, Schmidt KG, Soergel M. Cardiac function and structure in patients with chronic renal failure. Pediatr Nephrol 1999 13 : 951 965.
18. McMahon AC, Naqvi RU, Hurst MJ, Raine AE, MacLeod KT. Diastolic dysfunction and abnormality of the Na+/Ca2+ exchanger in single uremic cardiac myocytes. Kidney Int 2006 69 : 846 851.
19. Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007 115 : 3213 3223.
20. Potena L, Valantine HA. Cytomegalovirus-associated allograft rejection in heart transplant patients. Curr Opin Infect Dis 2007 20 : 425 431.
21. Petrakopoulou P, Kubrich M, Pehlivanli S et al. Cytomegalovirus infection in heart transplant recipients is associated with impaired endothelial function. Circulation 2004 110 (11 Suppl 1 II207 212.
22. Froberg MK, Adams A, Seacotte N, Parker-Thornburg J, Kolattukudy P. Cytomegalovirus infection accelerates inflammation in vascular tissue overexpressing monocyte chemoattractant protein-1. Circ Res 2001 89 : 1224 1230.
23. Arora S, Jenum PA, Aukrust P et al. Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality. J Am Coll Cardiol 2007 50 : 1967 1972.
24. Herijgers P, Nishimura Y, Flameng W. Endothelial activation through brain death? J Heart Lung Transplant 2004 23 (9 Suppl S234 239.
25. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007 357 : 1121 1135.
26. Przyklenk K, Whittaker P, Kloner RA. In vivo infusion of oxygen free radical substrates causes myocardial systolic, but not diastolic dysfunction. Am Heart J 1990 119 : 807 815.
27. Day JD, Rayburn BK, Gaudin PB et al. Cardiac allograft vasculopathy: The central pathogenetic role of ischemia-induced endothelial cell injury. J Heart Lung Transplant 1995 14 (6 Pt 2 S142 149.
28. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993 362 : 801 809.
29. Zou Y, Stastny P, Susal C, Dohler B, Opelz G. Antibodies against MICA antigens and kidney-transplant rejection. N Engl J Med 2007 357 : 1293 1300.
30. Suarez-Alvarez B, Lopez-Vazquez A, Gonzalez MZ et al. The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection. Am J Transplant 2007 7 : 1842 1848.
31. Smith JD, Hamour IM, Burke MM et al. A reevaluation of the role of IgM Non-HLA antibodies in cardiac transplantation. Transplantation 2009 87 : 864 871.
32. Stovin PG, English TA. Effects of cyclosporine on the transplanted human heart. J Heart Transplant 1987 6 : 180 185.
33. Atkison PR, Joubert GI, Guiraudon C et al. Arteritis and increased intracellular calcium as a possible mechanism for tacrolimus-related cardiac toxicity in a pediatric transplant recipient. Transplantation 1997 64 : 773 775.