Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 20, 2009, Pages 5848-5850

  Salzameda, Nicholas T ^a   Barbieri, Joseph T ^b   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Botulinum neurotoxin B; FRET based peptide substrate, metalloproteases; High throughput assay

Indexed keywords

BOTULINUM NEUROTOXIN B PROTEASE INHIBITOR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; DRUG INHIBITION; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; BOTULINUM TOXINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEASE INHIBITORS;

EID: 70349218029     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.079     Document Type: Article

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