Serum concentrations of keratan sulfate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to Standardbred horses during race training

American Journal of Veterinary Research

Volumn 63, Issue 8, 2002, Pages 1106-1110

  Caron, John P ^a   Peters, Tonia L ^a   Hauptman, Joseph G ^a   Eberhart, Susan W ^a   Orth, Michael W ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GLUCOSAMINE; GLUCOSE; KERATAN SULFATE; OSTEOCALCIN; PYRIDINOLINE;

ARTICLE; BLOOD LEVEL; BONE METABOLISM; CARTILAGE; CONTROLLED STUDY; DRUG EFFECT; HORSE; NONHUMAN; RANDOMIZATION; TIME; TRAINING;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0036701565     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2002.63.1106     Document Type: Article

References (39)

1. Thonar EJ, Lenz ME, Klintworth GK, et al. Quantification of keratan sulfate in blood as a marker of cartilage catabolism. Arthritis Rheum 1985;28:1367-1376.
2. Manicourt DH, Lenz ME, Thonar EJ. Levels of serum keratan sulfate rise rapidly and remain elevated following anterior cruciate ligament transection in the dog. J Rheumatol 1991;18:1872-1876.
3. Campion GV, McCrae F, Schnitzer TJ, et al. Levels of keratan sulfate in the serum and synovial fluid of patients with osteoarthritis of the knee. Arthritis Rheum 1991;34:1254-1259.
4. Todhunter RJ, Fubini SL, Freeman KP, et al. Concentration of keratan sulfate in plasma and synovial fluid from clinically normal horses and horses with joint disease. J Am Vet Med Assoc 1997;210:369-374.
5. Todhunter RJ, Yeager AE, Freeman KP, et al. Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in ponies. Am J Vet Res 1993,54:1007-1016.
6. Alwan WH, Carter SD, Bennett D, et al. Cartilage breakdown in equine osteoarthritis: measurement of keratan sulphate by an ELISA system. Res Vet Sci 1990;49:56-60.
7. Okumura M, Tagami M, Fujinaga T. Measurement of serum and synovial fluid keratan sulphate and antibody to collagen type II in equine osteoarthritis. Zentralbl Veterinarmed [A] 1998;45:513-516.
8. Sharif M, George E, Dieppe PA. Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee. Arthritis Rheum 1995;38:78-81.
9. Thompson PW, Specter TD, James IT, et al. Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis. Br J Rheumatol 1992;31:759-761.
10. Arican M, Carter SD, Bennett D. Osteocalcin in canine joint diseases. Br Vet J 1996;152:411-423.
11. Takahashi M, Kushida K, Hoshino H, et al. Concentrations of pyridinoline and deoxypyridinoline in joint tissues from patients with osteoarthritis or rheumatoid arthritis. Ann Rheum Dis 1996;55:324-327.
12. Pullig O, Weseloh, G, Ronneberger D, et al. Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Calcif Tissue Int 2000; 67:230-240.
13. MacDonald AG, McHenry P, Robins SP, et al. Relationship of urinary pyridinium crosslinks to disease extent and activity in osteoarthritis. Br J Rheumatol 1994;33:16-19.
14. Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am 1999;25:379-395.
15. Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev 1998;3:27-39.
16. Reichelt A, Forster KK, Fischer M, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. Arzneimittelforschung 1994;44:75-80.
17. Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-474.
18. McAlindon TE, LaValley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000;283:1469-1475.
19. Hansen RR. Oral glycosaminoglycans in the treatment of degenerative joint disease in horses. Equine Pract 1996;18:18-21.
20. Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage 1998;6:427-434.
21. Setnikar I. Antireactive properties of "chondroprotective" drugs. Int J Tissue React 1992;14:253-261.
22. Bassleer C, Henrotin Y, Franchimont P. In-vitro evaluation of drugs proposed as chondroprotective agents. Int J Tissue React 1992;14:231-241.
23. Piperno M, Reboul P, Hellio Le Graverand MP, et al. Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage 2000,8:207-212.
24. Fenton JI, Chlebek-Brown KA, Peters TA, et al. Glucosamine reduces equine articular cartilage degradation in explant culture. Osteoarthritis Cartilage 2000;8:258-265.
25. Fenton JI, Chlebek-Brown KA, Peters TA, et al. Effects of glucosamine derivatives on equine articular degradation in explant culture. Osteoarthritis Cartilage 2000;8:444-451.
26. Williams JM, Downey C, Thonar EJ. Increase in levels of serum keratan sulfate following cartilage proteoglycan degradation in the rabbit knee joint. Arthritis Rheum 1988;31:557-560.
27. Fenton JI, Orth MW, Nielsen BD, et al. Influence of longing and glucosamine on serum markers of bone and cartilage metabolism in Quarter horse yearlings. Can J Vet Res 1999;63:288-291.
28. Lang, KJ, Nielsen BD, Waite KL, et al. Supplemental silicon increases plasma and milk silicon concentrations in horses. J Anim Sci 2001;79:2627-2633.
29. Firth EC, Delahunt J, Wichtel JW, et al. Galloping exercise induces regional changes in bone density within the third and radial carpal bones of Thoroughbred horses. Equine Vet J 1999;31:111-115.
30. Firth EC, Goodship, AE, Delahunt J, et al. Osteoinductive response in the dorsal aspect of the carpus of young thoroughbreds in training occurs within months. Equine Vet J Suppl 1999;30:552-554.
31. McCarthy RN, Jeffcott LB. Effects of treadmill exercise on cortical bone in the third metacarpus of young horses. Res Vet Sci 1992;52:28-37.
32. Barnveld A, van Weeren PR, Early changes in the distal intertarsal joint of Dutch Warmblood foals and the influence of exercise on bone density in the third tarsal bone. Equine Vet J 1999;31:67-73.
33. Young DR, Richardson DW, Markel MD, et al. Mechanical and morphometric analysis of the third carpal bone of Thoroughbreds. Am J Vet Res 1991;52:402-409.
34. Eliakim A, Raisz LG, Brasel JA, et al. Evidence for increased bone formation following a brief endurance-type training intervention in adolescent males. J Bone Miner Res 1997;12:1708-1713.
35. Woitge HW, Friedmann B, Suttner S, et al. Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res 1998;13:1797-1804.
36. Fujimura R, Ashizawa N, Watanabe M, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res 1997;12:656-662.
37. Price JS, Jackson B, Eastell R, et al. The response of the skeleton to physical training: a biochemical study in horses. Bone 1995;17:221-227.
38. Okumura M, Fujinaga T, Urakawa E, et al. Evaluation of the catabolic activity of cartilage by measurement of serum keratan sulfate concentration in foals. Am J Vet Res 1997;58:925-929.
39. Roos H, Dahlberg L, Hoerrner LA, et al. Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise. Osteoarthritis Cartilage 1995;3:7-14.