Validation of a new HPLC method for determination of midazolam and its metabolites: Application to determine its pharmacokinetics in human and measure hepatic CYP3A activity in rabbits

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 987-993

  Elbarbry, Fawzy ^a   Attia, Ahmed ^b   Shoker, Ahmed ^b  

^a PACIFIC UNIVERSITY   (United States)

^b ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

CYP3A; HPLC; Midazolam; Pharmacokinetics; Therapeutic drug monitoring

Indexed keywords

1 HYDROXYMIDAZOLAM; 4 HYDROXYMIDAZOLAM; CYTOCHROME P450 3A; DRUG METABOLITE; HYDROXYL GROUP; LORAZEPAM; MIDAZOLAM; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET RADIATION; VALIDATION STUDY;

ADULT; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; DRUG MONITORING; FEMALE; HUMANS; LIVER; MICROSOMES; MIDAZOLAM; OXYGEN; QUALITY CONTROL; RABBITS; REPRODUCIBILITY OF RESULTS;

EID: 70349171285     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.07.004     Document Type: Article

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