Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities

Virology

Volumn 246, Issue 2, 1998, Pages 298-305

  Hwang, Ying T ^a   Smith, Jennifer F ^a   Gao, Li ^a   Hwang, Charles B C ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; APHIDICOLIN; GANCICLOVIR; NUCLEOSIDE ANALOG; PHOSPHONOACETIC ACID;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE EXPRESSION; GENE STRUCTURE; HERPES SIMPLEX VIRUS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS RESISTANCE;

DNA VIRUSES; HERPES; SIMPLEXVIRUS;

EID: 0032486604     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9201     Document Type: Article

References (35)

1. Cheng Y.-C., Huang E.-S., Lin J.-C., Mar E.-C., Pagano J. S., Dutschman G. E., Grill S. P. Unique spectrum of activity of 9-[1,3-dihydroxy-2-propoxy)methyl]guanine against herpesvirus in vitro and its mode of action against herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA. 80:1983;2767-2770.
2. Coen D. M. Viral DNA polymerases. DNA Replication in Eukaryotic Cells. 1996;Cold Spring Harbor Laboratory Press, Cold Spring Harbor. p. 495-523.
3. De Clercq E., Descamps J., De Somer P., Barr P. J., Jones A. S., Walker R. T. (E)-5-(2-Bromovinyl)-2′-deoxyuridine: A potent and selective anti-herpes agent. Proc. Natl. Acad. Sci. USA. 76:1979;2947-2951.
4. Derbyshire V., Grindley N. D. F., Joyce C. M. The 3′-5′ exonuclease of DNA polymerase ofEscherichia coli: EMBO J. 10:1991;17-24.
5. Derbyshire V., Freemont P. S., Sanderson M. R., Beese L., Friedman J. M., Joyce C. M., Steitz T. A. Genetic and crystallographic identification of essential groups in the 3′-5′ exonucleolytic site of DNA polymerase. Science. 240:1988;199-210.
6. Derse D., Bastow K. F., Cheng Y.-C. Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid. J. Biol. Chem. 257:1982;10251-10260.
7. Freemont P. S., Friedman J. M., Beese L. S., Sanderson M. R., Steitz T. A. Cocrystal structure of an editing complex of Klenow fragment with DNA. Proc. Natl. Acad. Sci. USA. 85:1988;8924-8928.
8. Frey M. W., Nossal N. G., Capson T. L., Benkovic S. J. Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3′-5′ exonuclease activity. Proc. Natl. Acad. Sci. USA. 90:1993;2579-2583.
9. Elion G. B., Furman P. A., Fyfe J. A., De Miranda P., Beauchamp L., Schaeffer H. J. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc. Natl. Acad. Sci. USA. 74:1977;5716-5720.
10. Garnier J., Osguthorpe D. J., Robson B. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120:1978;97-120.
11. Gentry G. A., Aswell J. F. Inhibition of herpes simplex virus replication by AraT. Virology. 65:1975;294-296.
12. Gibbs J. S., Chiou H. C., Bastow K. F., Cheng Y.-C., Coen D. M. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc. Natl. Acad. Sci. USA. 85:1988;6672-6676.
13. Gibbs J. S., Weisshart K., Digard P., DeBruynkops A., Knipe D. M., Coen D. M. Polymerization activity of an α-like DNA polymerase requires a conserved 3′-5′ exonuclease active site. Mol. Cell. Biol. 11:1991;4786-4795.
14. Haffey M. L., Novonty J., Bruccoleri R. E., Carroll R. D., Stevens J. T., Matthews J. T. Structure-function studies of the herpes simplex virus DNA polymerase. J. Virol. 64:1990;5008-5018.
15. Hall J. D., Orth K. L., Sander K. L., Swihart B. M., Senese R. A. Mutations within conserved motifs in the 3′-5′ exonuclease domain of herpes simplex virus DNA polymerase. J. gen. Virol. 76:1995;2999-3008.
16. Hall J. D., Wang Y., Pierpont J., Berlin M. S., Rundlett S. E., Woodward S. Aphidicolin resistance in herpes simplex virus type 1 reveals features of the DNA polymerase dNTP binding site. Nucleic Acids Res. 17:1989;9231-9244.
17. Hwang C. B. C., Ruffner K. L., Coen D. M. A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J. Virol. 66:1992;1774-1776.
18. Hwang Y. T., Liu B.-Y., Coen D. M., Hwang C. B. C. Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J. Virol. 71:1997;7791-7798.
19. Joyce C. M., Steitz T. A. Function and structure relationships in DNA polymerases. Annu. Rev. Biochem. 63:1994;777-822.
20. Kesti T., Frantti H., Syväoja J. E. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase ε J. Biol. Chem. 268:1993;10238-10245.
21. Knopf C. W. Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity. Eur. J. Biochem. 98:1979;231-244.
22. Knopf C. W., Weisshart K. Comparison of exonucleolytic activities of herpes simplex virus type-1 DNA polymerase and DNase. Eur. J. Biochem. 191:1990;263-273.
23. Kühn F. J. P., Knopf C. W. Herpes simplex virus type 1 DNA polymerase: Mutational analysis of the 3′-5′ exonuclease domain. J. Biol. Chem. 271:1996;29245-29254.
24. Larder B. A., Kemp S. D., Darby G. Related functional domains in virus DNA polymerases. EMBO J. 6:1987;169-175.
25. Marcy A. I., Olivo P. D., Challberg M. D., Coen D. M. Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Nucleic Acids Res. 18:1990;1207-1215.
26. Morrison A., Bell J. B., Kunkel T. A., Sugino A. Eukaryotic DNA polymerase amino acid sequence required for 3′-5′ exonuclease activity. Proc. Natl. Acad. Sci. USA. 88:1991;9473-9477.
27. North T. W., Cohen S. S. Aranucleosides and aranucleotides in viral chemotherapy. Pharmacol. Ther. 4:1979;81-108.
28. Reha-Krantz L. J., Nonay R. L. Genetic and biochemical studies of bacteriophage T4 DNA polymerase 3′ → 5′ exonuclease activity. J. Biol. Chem. 268:1993;27100-27108.
29. Reha-Krantz L. J., Stocki S., Nonay R. L., Dimayauga E., Goodrich L. D., Konigsberg W. H., Spicer E. K. DNA polymerization in the absence of exonucleolytic proofreading:In vivoin vitro. Proc. Natl. Acad. Sci. USA. 88:1991;2417-2421.
30. Simon M., Giot L., Faye G. The 3′-5′ exonuclease activity located in the DNA polymerase δ subunit ofSaccharomyces cerevisiae. EMBO J. 10:1991;2165-2170.
31. Soengas M. S., Esteban J. A., Lazaro J. M., Bernad A., Blasco M. A., Salas M., Blanco L. Site-directed mutagenesis at the Exo III motif of φ29 DNA polymerase: Overlapping structural domains for the 3′-5′ exonuclease and strand-displacement activities. EMBO J. 11:1992;4227-4237.
32. 125. J. Virol. 24:1977;314-318.
33. Wang Y., Woodward S., Hall J. D. Use of suppressor analysis to identify DNA polymerase mutations in herpes simplex virus which affect deoxynucleotide triphosphate substrate specificity. J. Virol. 66:1992;1814-1816.
34. Weisshart K., Kuo A., Hwang C. B. C., Kumura K., Coen D. M. Structural and functional organization of herpes simplrx virus DNA polymerase investigated by limited proteolysis. J. Biol. Chem. 269:1994;22788-22796.
35. Zhang J., Chung D. W., Tan C.-K., Downey K. M., Davie E. W., So A. G. Primary structure of the catalytic subunit of calf thymus DNA polymerase δ: Sequence similarities with other DNA polymerases. Biochemistry. 30:1991;11742-11750.