Concerning the hydrolytic stability of 8-aryl-2′-deoxyguanosine nucleoside adducts: Implications for abasic site formation at physiological pH

Journal of Organic Chemistry

Volumn 74, Issue 16, 2009, Pages 5793-5802

  Schlitt, Katherine M ^a   Sun, Ke Wen M ^a   Paugh, Robert J ^a   Millen, Andrea L ^b   Navarro Whyte, Lex ^b   Wetmore, Stacey D ^b   Manderville, Richard A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBONS; BEARINGS (STRUCTURAL); BIOMOLECULES; CHEMICAL REACTIONS; DENSITY FUNCTIONAL THEORY; HYDROGEN; HYDROGEN BONDS; HYDROLYSIS; NUCLEIC ACIDS; PHENOLS; POLYCYCLIC AROMATIC HYDROCARBONS; SUGAR (SUCROSE); SUGARS; ULTRAVIOLET SPECTROSCOPY;

ACID-CATALYZED HYDROLYSIS; ACIDIC MEDIA; ANTI ORIENTATION; ARYL RINGS; ARYLHYDRAZINES; CHEMICAL EQUATIONS; COMMON PROPERTY; DENSITY FUNCTIONAL THEORY CALCULATIONS; DEOXYGUANOSINE (DG); DUPLEX DNA; GLYCOSIDIC BOND CLEAVAGE; HYDROLYSIS KINETICS; HYDROLYTIC STABILITY; IONIZATION CONSTANT; NEUTRAL PH; NUCLEOBASES; PHYSIOLOGICAL PH; PROTON AFFINITY; PROTONATED; RADICAL SPECIES; SITE FORMATION; STRUCTURAL FEATURE; SUGAR LOSS; UV-VIS SPECTROSCOPY;

PH EFFECTS;

DEOXYGUANOSINE DERIVATIVE; DOUBLE STRANDED DNA; DEOXYGUANOSINE; DNA ADDUCT;

ADDUCTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYCLOADDITION; DENSITY FUNCTIONAL THEORY; DNA ADDUCT; DNA MODIFICATION; DNA STRUCTURE; GENETIC STABILITY; HYDROGEN BOND; HYDROLYSIS KINETICS; IONIZATION; MOLECULAR PROBE; PH; PROTEIN CLEAVAGE; PROTEIN STRUCTURE; PROTON TRANSPORT; REACTION TIME; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; CONFORMATION; HYDROLYSIS; KINETICS; QUANTUM THEORY; STEREOISOMERISM;

DEOXYGUANOSINE; DNA ADDUCTS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTUM THEORY; STEREOISOMERISM;

EID: 70349129952     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901080w     Document Type: Article

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