Involvement of human organic cation transporter 1 in the hepatic uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4, 9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel, small molecule survivin suppressant

Drug Metabolism and Disposition

Volumn 37, Issue 9, 2009, Pages 1856-1863

  Iwai, Megumi ^a   Minematsu, Tsuyoshi ^a   Narikawa, Shinichi ^b   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b Sugi Institute of Biological Science   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYETHOXY) 2 METHYL 3 (2 PYRAZINYLMETHYL)NAPHTHO[2,3 D]IMIDAZOLE 4,9 DIONE; 1 (2 METHOXYETHYL) 2 METHYL 4,9 DIOXO 3 (PYRAZIN 2 YLMETHYL) 4,9 DIHYDRO 1H NAPHTHO[2,3 D]IMIDAZOLIUM BROMIDE; IMIDAZOLE DERIVATIVE; ORGANIC CATION TRANSPORTER 1; SURVIVIN; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG CLEARANCE; DRUG DIFFUSION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL; LIVER CLEARANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; TEMPERATURE DEPENDENCE;

CELLS, CULTURED; CRYOPRESERVATION; HEPATOCYTES; HUMANS; IMIDAZOLES; KIDNEY TUBULES, PROXIMAL; KINETICS; LIVER; MICROTUBULE-ASSOCIATED PROTEINS; NAPHTHOQUINONES; ORGANIC CATION TRANSPORTER 1;

EID: 70349129034     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027359     Document Type: Article

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