Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of YM155, a novel small-molecule survivin suppressant, in dog plasma

Biomedical Chromatography

Volumn 22, Issue 7, 2008, Pages 763-769

  Minematsu, Tsuyoshi ^a   Felder, Laurie ^b   Oppeneer, Todd ^b   Sakazume, Masashi ^a   Oikawa, Keishi ^a   Hashimoto, Tadashi ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b 206 Carnegie Center   (United States)

Author keywords

Bioanalytical method; Dog plasma; LC MS MS; Pharmacokinetics; Validation; YM155

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; SILICA;

BIOANALYTICAL METHODS; DOG PLASMA; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; SMALL MOLECULES; SURVIVIN; TANDEM MASS SPECTROMETRIC; VALIDATION; YM155;

PHARMACOKINETICS;

1 (2 METHOXYETHYL) 2 METHYL 4,9 DIOXO 3 (PYRAZIN 2 YLMETHYL) 4,9 DIHYDRO 1H NAPHTHO[2,3 D]IMIDAZOLIUM; ACETONITRILE; AMMONIUM ACETATE; ANTINEOPLASTIC AGENT; FORMIC ACID; SURVIVIN; WATER; YM155;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FREEZE THAWING; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS;

CANIS FAMILIARIS;

EID: 48349122649     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.996     Document Type: Article

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