Do defects in the late sodium current in human ventricular cells cause heart failure?

Journal of Molecular and Cellular Cardiology

Volumn 34, Issue 11, 2002, Pages 1473-1476

  Goldman, L ^b   Balke, C William ^a,b  

^a Department of Medicine ^*  (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM; SODIUM CHANNEL; VOLTAGE GATED NA+ CHANNEL NA(V)1.5A; VOLTAGE-GATED NA+ CHANNEL NA(V)1.5A;

CHANNEL GATING; CONDUCTANCE; EDITORIAL; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE; HUMAN; HUMAN CELL; PATCH CLAMP; PATHOGENESIS; PRIORITY JOURNAL; SODIUM CURRENT; ACTION POTENTIAL; CELL CULTURE; CONGESTIVE HEART FAILURE; CYTOLOGY; HEART MUSCLE; HEART VENTRICLE FIBRILLATION; ION TRANSPORT; METABOLISM; NOTE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ACTION POTENTIALS; CELLS, CULTURED; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HUMANS; ION CHANNEL GATING; ION TRANSPORT; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; SODIUM; SODIUM CHANNELS; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 1842854228     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2002.2109     Document Type: Editorial

References (14)

1. American Heart Association. 2002 Heart and Stroke Statistical Update, Dallas, Tex.: American heart Association: 2001.
2. Moser DK, Mann DL. Improving outcomes in heart failure. Circulation 2002; 105: 2810-2812.
3. McCullough PA, Philbin EF, Spertus JA, Kaatz S, Sandberg KR, Weaver WD. Confirmation of a heart failure epidemic: Findings from the Resource Utilization Among Congestive Heart Failure (REACH) study. J Am Coll Cardiol 2002; 39(1): 60-69.
4. Goff Dc Jr, Pandey DK, Chan FA, Ortiz C, Nichaman MZ. Congestive heart failure in the United States: Is there more than meets the I(CD code)? The Corpus Christi Heart Project. Arch Intern Med 2000; 160(2): 197-202.
5. Mendez GF, Cowie MR. The epidemiological features of heart failure in developing countries: A review of the literature. Int J Cardiol 2001; 80(2-3): 213-219.
6. O'Connell JB. The economic burden of heart failure. Clin Cardiol 2000; 23(3 Suppl.): III6-III10.
7. Haldeman GA, Croft JB, Giles WH, Rashidee A. Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985 to 1995. Am Heart J 1999; 137(2): 352-360.
8. MacIntyre K, Capewell S, Stewart S, Chalmers JW, Boyd J, Finlayson A, Redpath A, Pell JP, Mcmurray JJ. Evidence of improving prognosis in heart failure: Trends in case fatality in 66 547 patients hospitalized between 1986 and 1995. Circulation 2000; 102(10): 1126-1131.
9. + channel in normal and failing human myocardium. J Mol Cell Cardiol 2002; 34: 1477-1489, next article in this issue.
10. Maltsev VA, Sabbah HN, Higgins RSD, Silverman N, Lesch M, Undrovinas AI. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 1998; 98: 2545-2552.
11. Maltsev VA Undrovinas AI. Late sodium current in heart failure. (Abstract) Circulation 2000; 102: II-449
12. + channel in normal and failing myocardium [abstract], Circulation 2000; 102: II-594.
13. + channel currents in frog sartorius muscle. J Gen Physiol 1986; 87: 305-326.
14. Gaughan JP, Furukawa S, Houser SR. Tetrodotoxin-sensitive calcium current induces contraction in failed human ventricular myocytes [abstract]. Circulation 1999; 100: I-422.