Cyclic opioid peptide agonists and antagonists obtained via ring-closing metathesis

Chemical Biology and Drug Design

Volumn 74, Issue 4, 2009, Pages 329-334

  Berezowska, Irena ^a   Lemieux, Carole ^a   Chung, Nga N ^a   Wilkes, Brian C ^a   Schiller, Peter W ^a,b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Opioid activity profiles; Opioid peptide analogues; Opioid peptide SAR; Peptide synthesis; Ring closing metathesis

Indexed keywords

2 AMINO 5 HEXENOIC ACID; 2 METHYL 3 (2,6 DIMETHYL 4 HYDROXYPHENYL)PROPANOIC ACID; 2 METHYL 3 (2,6 DIMETHYL 4 HYDROXYPHENYL)PROPANOIC ACID CYCLO(DEXTRO ALLYLGLYCYLPHENYLALANYLPHENYLALANYL 2 AMINO 5 HEXENOIC ACID)AMIDE; 2',6' DIMETHYLTYROSINE; 3 (2,6 DIMETHYL 4 HYDROXYPHENYL)PROPANOIC ACID; 3 (2,6 DIMETHYL 4 HYDROXYPHENYL)PROPANOIC ACID CYCLO(DEXTRO ALLYLGLYCYLPHENYLALANYLPHENYLALANYL 2 AMINO 5 HEXENOIC ACID)AMIDE; ACRYLIC ACID DERIVATIVE; ALLYLGLYCINE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; H 2',6' DIMETHYLTYROSINE CYCLO(DEXTRO ALLYLGLYCYLPHENYLALANYLPHENYLALANYL 2 AMINO 5 HEXENOIC ACID)AMIDE; H TYROSINE CYCLO(DEXTRO ALLYLGLYCYLPHENYLALANYLPHENYLALANYL 2 AMINO 5 HEXENOIC ACID)AMIDE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; OPIATE PEPTIDE; PROPIONIC ACID DERIVATIVE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CIS TRANS ISOMERISM; CONTROLLED STUDY; DRUG CONFORMATION; HYDROGENATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RING CLOSING METATHESIS; SOLID PHASE SYNTHESIS; SUBSTITUTION REACTION;

AMINO ACID SEQUENCE; ANALGESICS, OPIOID; OPIOID PEPTIDES; PEPTIDES, CYCLIC; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 70349106893     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00867.x     Document Type: Article

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