Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, brown Norway, and chromosome 13-substituted consomic rat strains: Role of large conductance Ca2+ and voltage-activated potassium channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 3, 2009, Pages 727-735

  Stadnicka, Anna ^a   Contney, Stephen J ^a   Moreno, Carol ^a   Weihrauch, Dorothee ^a   Bosnjak, Zeljko J ^a   Roman, Richard J ^a   Stekiel, Thomas A ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; IBERIOTOXIN; PROPOFOL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BROWN NORWAY RAT; CALCIUM CONDUCTANCE; CARDIOVASCULAR RESPONSE; CHROMOSOME 13; CHROMOSOME SUBSTITUTION STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; GENETIC VARIABILITY; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; MESENTERY BLOOD FLOW; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BENZIMIDAZOLES; CHROMOSOMES; HEMODYNAMICS; HUMANS; HYPNOTICS AND SEDATIVES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS, VOLTAGE-GATED; PROPOFOL; RATS; RATS, INBRED BN; RATS, INBRED DAHL; SPECIES SPECIFICITY; SPLANCHNIC CIRCULATION; VASCULAR RESISTANCE;

EID: 70349106455     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.154104     Document Type: Article

References (38)

1. + channels as a mechanism of agonist-induced vasoconstriction. Proc Natl Acad Sci U S A 99:14560-14565.
2. Boillot A, Laurant P, Berthelot A, and Barale F (1999) Effects of propofol on vascular reactivity in isolated aorta from normotensive and spontaneously hypertensive rats. Br J Anaesth 83:622-629. (Pubitemid 29458831)
3. Bray RJ (2002) The propofol infusion syndrome in infants and children: can we predict the risk. Curr Opin Anaesthesiol 15:339-342.
4. 1 subunit of the calcium-activated potassium channel. Nature 407:870-876.
5. Chang T, Wu L, and Wang R (2006) Altered expression of BK channel β1 subunit in vascular tissues from spontaneously hypertensive rats. Am J Hypertens 19:678-685. (Pubitemid 43928523)
6. Cowley AW Jr, Liang M, Roman RJ, Greene AS, and Jacob HJ (2004) Consomic rat model systems for physiological genomics. Acta Physiol Scand 181:585-592. (Pubitemid 39078858)
7. Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, and Jacob HJ (2001) Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension 37:456-461. (Pubitemid 32199011)
8. Cox RH (2002) Changes in the expression and function of arterial potassium channels during hypertension. Vascul Pharmacol 38:12-23.
9. + current components in mesenteric artery myocytes from WKY and SHR. Am J Hypertens 14:897-907.
10. Cox RH and Rusch NJ (2002) New expression profiles of voltage-gated ion channels in arteries exposed to high blood pressure. Microcirculation 9:243-257.
11. Drenjancevic-Peric I and Lombard JH (2005) Reduced angiotensin II and oxidative stress contribute to impaired vasodilation in Dahl salt-sensitive rats on low-salt diet. Hypertension 45:687-691. (Pubitemid 40418366)
12. Garrett MR, Dene H, and Rapp JP (2003) Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14:1175-1187. (Pubitemid 36514660)
13. Ghatta S, Nimmagadda D, Xu X, and O'Rourke ST (2006) Large-conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol Ther 110:103-116. (Pubitemid 43248728)
14. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85-100. (Pubitemid 11012976)
15. Ca is involved in the relaxing effect of propofol on coronary arteries. Eur J Anaesthesiol 21:226-230.
16. Kokita N, Stekiel TA, Yamazaki M, Bosnjak ZJ, Kampine JP, and Stekiel WJ (1999) Potassium channel mediated hyperpolarization of mesenteric vascular smooth muscle by isoflurane. Anesthesiology 90:779-788. (Pubitemid 29113699)
17. Krassioukov AV, Gelb AW, and Weaver LC (1993) Action of propofol on central sympathetic mechanisms controlling blood pressure. Can J Anaesth 40:761-769.
18. + currents in rat arterial smooth muscle cells through protein kinase C. J Physiol 503:489-496.
19. Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, and Jacob HJ (2006) Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. Physiol Genomics 26:218-225. (Pubitemid 44246628)
20. Lu R, Alioua A, Kumar Y, Eghbali M, Stefani E, and Toro L (2006) Maxi-K channel partners: physiological impact. J Physiol 570:65-72.
21. v,Caβ) of maxi K channels. FEBS Lett 382:84-88.
22. Nagakawa T, Yamazaki M, Hatakeyama N, and Stekiel TA (2003) The mechanisms of propofol-mediated hyperpolarization of in situ rat mesenteric vascular smooth muscle. Anesth Analg 97:1639-1645. (Pubitemid 37475114)
23. Nakamura K, Hatano Y, Hirakata H, Nishiwada M, Toda H, and Mori K (1992) Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. Br J Anaesth 68:193-197.
24. Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, and Lederer WJ (1995) Relaxation of arterial smooth muscle by calcium sparks. Science 270:633-637.
25. Pensado A, Molins N, and Alvarez J (1993) Effects of propofol on mean arterial pressure and systemic vascular resistance during cardiopulmonary bypass. Acta Anaesthesiol Scand 37:498-501. (Pubitemid 23203962)
26. Rapp JP (1994) Characteristics of Dahl salt-susceptible and salt-resistant rats, in Handbook of Hypertension, Vol.4: Experimental and Genetic Models of Hypertension (de Jong W ed), vol 4, pp. 286-295, Elsevier Science Publishers B.V., Amsterdam, The Netherlands.
27. Roman RJ, Cowley AW Jr, Greene A, Kwitek AE, Tonellato PJ, and Jacob HJ (2002) Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harb Symp Quant Biol 67:309-315. (Pubitemid 36775525)
28. + channel modulation in arterial smooth muscle. Acta Physiol Scand 164:549-557.
29. Stekiel TA, J Contney S, Bosnjak ZJ, Kampine JP, Roman RJ, and Stekiel WJ (2004) Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution. Anesthesiology 101:796-798.
30. Stekiel TA, Contney SJ, Bosnjak ZJ, Kampine JP, Roman RJ, and Stekiel WJ (2006) Chromosomal substitution-dependent differences in cardiovascular responses to sodium pentobarbital. Anesth Analg 102:799-805.
31. Stekiel TA, Contney SJ, Kokita N, Bosnjak ZJ, Kampine JP, and Stekiel WJ (2001) Mechanism of isoflurane-mediated hyperpolarization of vascular smooth muscle in chronically hypertensive and normotensive conditions. Anesthesiology 94:496-506. (Pubitemid 32198460)
32. Stekiel TA, Weber CA, Contney SJ, and Bosnjak ZJ (2007) Differences in cardiovascular sensitivity to propofol in a chromosome substitution rat model. Croat Med J 48:312-318.
33. Toro L, Alioua A, Mahajan A, Nishimaru K, Zarei MM, and Stefani E (2004) MaxiK, c-Src and vasoconstriction. J Muscle Res Cell Motil 25:616-617.
34. Ca, a unique member of the voltage-gated K channel superfamily. News Physiol Sci 13:112-117.
35. White PF (2008) Propofol. Its role in changing the practice of anesthesia. Anesthesiology 109:1132-1136.
36. Yamashita A, Kajikuri J, Ohashi M, Kanmura Y, and Itoh T (1999) Inhibitory effects of propofol on acetylcholine-induced, endothelium-dependent relaxation and prostacyclin synthesis in rabbit mesenteric resistance arteries. Anesthesiology 91:1080-1089. (Pubitemid 29466544)
37. Yamazaki M, Nagakawa T, Hatakeyama N, Shibuya N, and Stekiel TA (2002) The effects of propofol on neural and endothelial control of in situ rat mesenteric vascular smooth muscle transmembrane potentials. Anesth Analg 94:892-897, table of contents. (Pubitemid 34263735)
38. Yamazaki M, Stekiel TA, Bosnjak ZJ, Kampine JP, and Stekiel WJ (1998) Effects of volatile anesthetic agents on in situ vascular smooth muscle transmembrane potential in resistance- and capacitance-regulating blood vessels. Anesthesiology 88:1085-1095. (Pubitemid 28193337)