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Volumn 330, Issue 3, 2009, Pages 892-901

Pharmacological properties of 2-(R-5-chloro-4-methoxymethylindan-1-yl)-1H- imidazole (PF-3774076), a novel and selective α1A-adrenergic partial agonist, in in vitro and in vivo models of urethral function

Author keywords

[No Author keywords available]

Indexed keywords

2 (5 CHLORO 4 METHOXYMETHYLINDAN 1 YL) 1H IMIDAZOLE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; DABUZALGRON; PARTIAL AGONIST; PF 3774076; UNCLASSIFIED DRUG;

EID: 70349104264     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.154963     Document Type: Article
Times cited : (16)

References (38)
  • 1
    • 0037253578 scopus 로고    scopus 로고
    • The standardisation of terminology in lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society
    • DOI 10.1016/S0090-4295(02)02243-4
    • Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Van Kerrebroeck P, Victor A, and Wein A (2003) The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the international continence society. Urology 61:37-49. (Pubitemid 36151708)
    • (2003) Urology , vol.61 , Issue.1 , pp. 37-49
    • Abrams, P.1    Cardozo, L.2    Fall, M.3    Griffiths, D.4    Rosier, P.5    Ulmsten, U.6    Van Kerrebroeck, P.7    Victor, A.8    Wein, A.9
  • 2
    • 0033007051 scopus 로고    scopus 로고
    • Characterisation of the functional α-adrenoceptor subtype in the isolated female pig urethra
    • DOI 10.1016/S0014-2999(99)00182-X, PII S001429999900182X
    • Alberts P, Bergström PA, and Fredrickson MG (1999) Characterisation of the functional α-adrenoceptor subtype in the isolated female pig urethra. Eur J Pharmacol 371:31-38. (Pubitemid 29206459)
    • (1999) European Journal of Pharmacology , vol.371 , Issue.1 , pp. 31-38
    • Alberts, P.1    Bergstrom, P.A.C.2    Fredrickson, M.G.3
  • 3
    • 0034821159 scopus 로고    scopus 로고
    • Effects of selective autonomic and pudendal denervation on the urethral function and development of retention in female dogs
    • Ali-El-Dein B and Ghoneim MA (2001) Effects of selective autonomic and pudendal denervation on the urethral function and development of retention in female dogs. J Urol 166:1549-1554. (Pubitemid 32862236)
    • (2001) Journal of Urology , vol.166 , Issue.4 , pp. 1549-1554
    • Ali-El-Dein, B.1    Ghoneim, M.A.2
  • 6
    • 45449098743 scopus 로고    scopus 로고
    • Long-term efficacy of duloxetine in women with stress urinary incontinence
    • DOI 10.1111/j.1464-410X.2008.07577.x
    • Bump RC, Voss S, Beardsworth A, Manning M, Zhao YD, and Chen W (2008) Long term efficacy of duloxetine in women with stress urinary incontinence. BJU Int 102:214-218. (Pubitemid 351852592)
    • (2008) BJU International , vol.102 , Issue.2 , pp. 214-218
    • Bump, R.C.1    Voss, S.2    Beardsworth, A.3    Manning, M.4    Zhao, Y.D.5    Chen, W.6
  • 9
    • 0023243159 scopus 로고
    • Phenylpropanolamine in treatment of female stress urinary incontinence. Double-blind placebo controlled study in 24 patients
    • DOI 10.1016/0090-4295(87)90314-1
    • Collste L and Lindskog M (1987) Phenylpropanolamine in the treatment of stress urinary incontinence. Double blind placebo controlled study in 24 patients. J Urol 30:398-403. (Pubitemid 17149164)
    • (1987) Urology , vol.30 , Issue.4 , pp. 398-403
    • Collste, L.1    Lindskog, M.2
  • 10
    • 0023755523 scopus 로고
    • Chloralose alters the circulatory response to α-receptor stimulation and blockade
    • Covert RF, Drummond WH, Gimotty PA (1988) Chloralose alters the circulatory response to α-receptor stimulation and blockade. Am J Physiol 255 (3 Pt 2):H419-H425.
    • (1988) Am J Physiol , vol.255 , Issue.3 PART 2
    • Covert, R.F.1    Drummond, W.H.2    Gimotty, P.A.3
  • 13
    • 0018137624 scopus 로고
    • The effects of long-term treatment with norephedrine on stress incontinence and urethral closure pressure profile
    • Ek A, Andersson KE, Gullberg B, and Ulmsten U (1978) The effects of long-term treatment with norephedrine on stress incontinence and urethral closure pressure profile. Scand J Urol Nephrol 12:105-110. (Pubitemid 9018051)
    • (1978) Scandinavian Journal of Urology and Nephrology , vol.12 , Issue.2 , pp. 105-110
    • Ek, A.1    Andersson, K.E.2    Gullberg, B.3    Ulmsten, U.4
  • 14
    • 0031816354 scopus 로고    scopus 로고
    • The effect of phenylpropanolamine in the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetised, conscious dog
    • Gillberg PG, Fredrickson MG, Ohman BM, and Alberts P (1998) The effect of phenylpropanolamine in the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetised, conscious dog. Scand J Urol Nephrol 32:171-176.
    • (1998) Scand J Urol Nephrol , vol.32 , pp. 171-176
    • Gillberg, P.G.1    Fredrickson, M.G.2    Ohman, B.M.3    Alberts, P.4
  • 15
    • 0031596566 scopus 로고    scopus 로고
    • 1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: A model for lower urinary tract tissues of man
    • 1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br J Pharmacol 123:1359-1366.
    • (1998) Br J Pharmacol , vol.123 , pp. 1359-1366
    • Kava, M.S.1    Blue Jr., D.R.2    Vimont, R.L.3    Clarke, D.E.4    Ford, A.P.5
  • 16
    • 70349107590 scopus 로고    scopus 로고
    • Evaluation of the sensitivity of urethral pressure reflectometry (UPR) and urethral pressure profilometry (UPP) to detect pharmacological augmentation of urethral pressure, using [S, S]-Reboxetine
    • Klarskov N, Scholfield D, Soma K, Darekar A, Mills I, Lose G (2008) Evaluation of the sensitivity of urethral pressure reflectometry (UPR) and urethral pressure profilometry (UPP) to detect pharmacological augmentation of urethral pressure, using [S, S]-Reboxetine. J Urol 179:521-523.
    • (2008) J Urol , vol.179 , pp. 521-523
    • Klarskov, N.1    Scholfield, D.2    Soma, K.3    Darekar, A.4    Mills, I.5    Lose, G.6
  • 24
    • 3142526420 scopus 로고    scopus 로고
    • The effect of tamsulosin on the resting tone and the contractile behaviour of the female urethra: A functional urodynamic study in healthy women
    • DOI 10.1016/j.eururo.2004.04.009, PII S0302283804001770
    • Reitz A, Haferkamp A, Kyburz T, Knapp PA, Wefer B, and Schurch B (2004) The effect of tamsulosin on the resting tone and the contractile behaviour of the female urethra: a functional urodynamic study in healthy women. Eur Urol 46: 235-240. (Pubitemid 38902745)
    • (2004) European Urology , vol.46 , Issue.2 , pp. 235-240
    • Reitz, A.1    Haferkamp, A.2    Kyburz, T.3    Knapp, P.A.4    Wefer, B.5    Schurch, B.6
  • 25
    • 56549094203 scopus 로고    scopus 로고
    • Novel 2-imidazoles as potent, selective and CNS penetrant alpha(1A) adrenoceptor partial agonists
    • Roberts LR, Bryans J, Conlon K, McMurray G, Stobie A, and Whitlock GA (2008) Novel 2-imidazoles as potent, selective and CNS penetrant alpha(1A) adrenoceptor partial agonists. Bioorg Med Chem Lett 18:6437-6440.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 6437-6440
    • Roberts, L.R.1    Bryans, J.2    Conlon, K.3    McMurray, G.4    Stobie, A.5    Whitlock, G.A.6
  • 26
    • 0019880715 scopus 로고
    • Diagnosis of urinary incontinence of dogs: Role of the urethral pressure profile
    • Rosin AE and Barsanti JA (1981) Diagnosis of urinary incontinence of dogs: role of the urethral pressure profile. J Am Vet Med Assoc 178:814-822.
    • (1981) J Am Vet Med Assoc , vol.178 , pp. 814-822
    • Rosin, A.E.1    Barsanti, J.A.2
  • 27
    • 0033674519 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of duloxetine, a dual-serotonin and noradrenaline reuptake inhibitor
    • Sharma A, Goldberg MJ, and Cerimele BJ (2000) Pharmacokinetics and safety of duloxetine, a dual-serotonin and noradrenaline reuptake inhibitor. J Clin Pharmacol 40:161-167.
    • (2000) J Clin Pharmacol , vol.40 , pp. 161-167
    • Sharma, A.1    Goldberg, M.J.2    Cerimele, B.J.3
  • 28
    • 0035218417 scopus 로고    scopus 로고
    • Sphincteric musculature of female canine urethra in comparison to woman including 3d reconstruction
    • DOI 10.1159/000046188
    • Stolzenburg JU, Dorschner W, Postenjak M, Salomon FV, Jurina K, Do M, and Neuhaus J (2002) Sphincteric musculature of female canine urethra in comparison to woman including 3D reconstruction. Cells Tissues Organs 170:151-161. (Pubitemid 33151587)
    • (2001) Cells Tissues Organs , vol.170 , Issue.2-3 , pp. 151-161
    • Stolzenburg, J.-U.1    Dorschner, W.2    Postenjak, M.3    Salomon, F.-V.4    Jurina, K.5    Do, M.6    Neuhaus, J.7
  • 30
    • 0029027862 scopus 로고
    • Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anaesthetised female cat
    • Thor KB and Katofiasc MA (1995) Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anaesthetised female cat. J Pharmacol Exp Ther 274: 1014-1024.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1014-1024
    • Thor, K.B.1    Katofiasc, M.A.2
  • 32
    • 0035993390 scopus 로고    scopus 로고
    • Effect of phenylephrine injected into the nucleus tractus solitarius of Sprague-Dawley rats and spontaneously hypertensive rats
    • DOI 10.1016/S0361-9230(02)00757-8, PII S0361923002007578
    • Tsukamoto K, Ito S, Katsunuma N, Hiratsuka M, Masubuchi Y, Kanai T, Kawabe T, Yajima Y, and Kanmatsuse K (2002) Effect of phenylephrine injected into the nucleus tractus solitarius of Sprague-Dawley rats and spontaneously hypertensive rats. Brain Res Bull 58:351-356. (Pubitemid 34899630)
    • (2002) Brain Research Bulletin , vol.58 , Issue.4 , pp. 351-356
    • Tsukamoto, K.1    Ito, S.2    Katsunuma, N.3    Hiratsuka, M.4    Masubuchi, Y.5    Kanai, T.6    Kawabe, T.7    Yajima, Y.8    Kanmatsuse, K.9
  • 33
    • 0028363070 scopus 로고
    • Cardiovascular studies of phenylpropanolamine
    • Vick J, Weiss L, and Ellis S (1994) Cardiovascular studies of phenylpropanolamine. Arch Int Pharmacodyn Ther 327:13-24.
    • (1994) Arch Int Pharmacodyn Ther , vol.327 , pp. 13-24
    • Vick, J.1    Weiss, L.2    Ellis, S.3
  • 36
    • 0025832244 scopus 로고
    • Pharmacological characterisation of alpha adrenergic receptors in the young and old female rabbit urethra
    • Yoshida M, Latifpour J, Nishimoto T, and Weiss RM (1991) Pharmacological characterisation of alpha adrenergic receptors in the young and old female rabbit urethra. J Pharmacol Exp Ther 257:1100-1108.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 1100-1108
    • Yoshida, M.1    Latifpour, J.2    Nishimoto, T.3    Weiss, R.M.4
  • 37
    • 33846459380 scopus 로고    scopus 로고
    • 1-adrenoreceptors
    • DOI 10.1124/jpet.106.114033
    • Zhang W and Mifflin SW (2007) Modulation of synaptic transmission to second order peripheral chemoreceptor neurons in caudal nucleus tractus solitarius by α1- adrenoreceptors. J Pharmacol Exp Ther 320:670-677. (Pubitemid 46147947)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.2 , pp. 670-677
    • Zhang, W.1    Mifflin, S.W.2
  • 38
    • 67349187775 scopus 로고    scopus 로고
    • QA phase 2, 8 week, multi centred, randomised double blind, placebo controlled, parallel group study evaluating the efficacy, tolerability and safety of [S-S]-Reboxetine (PNU-165442G) for stress urinary incontinence in women
    • Zinner N, Scholfield D, Soma K, Grant L, and Mills I (2008) QA phase 2, 8 week, multi centred, randomised double blind, placebo controlled, parallel group study evaluating the efficacy, tolerability and safety of [S-S]-Reboxetine (PNU-165442G) for stress urinary incontinence in women. J Urol 179:569-570.
    • (2008) J Urol , vol.179 , pp. 569-570
    • Zinner, N.1    Scholfield, D.2    Soma, K.3    Grant, L.4    Mills, I.5


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