The effect of phenylpropanolamine on the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetized, conscious dog

Scandinavian Journal of Urology and Nephrology

Volumn 32, Issue 3, 1998, Pages 171-176

  Gillberg, Per Göran ^a   Fredrickson, M Gunnel ^a   Öhman, Birgitta M ^a   Alberts, Pèteris ^a  

^a Pharmacia & Upjohn AB   (Sweden)

Author keywords

ECG; Phenylpropanolamine; Stress incontinence; Urethra; Urethral pressure

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; NOREPHEDRINE; PHENYLPROPANOLAMINE; RINEXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DOG; DRUG FORMULATION; ELECTROCARDIOGRAM; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STRESS INCONTINENCE; SUSTAINED RELEASE PREPARATION; URETHRA;

ADRENERGIC AGENTS; ANIMALS; BLOOD PRESSURE; DELAYED-ACTION PREPARATIONS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART RATE; PHENYLPROPANOLAMINE; RECEPTORS, ADRENERGIC, ALPHA; URETHRA; URODYNAMICS;

EID: 0031816354     PISSN: 00365599     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655998750015520     Document Type: Article

References (38)

1. 3H-noradrenaline secretion in guinea-pig isolated urethra. Br J Pharmacol 1992; 105: 142-146.
2. 2-adrenoceptors. Gen Pharmacol 1993; 24: 1-8.
3. 3H-noradrenaline secretion in the guinea-pig urethra. Pharmacol Toxicol 1995; 77: 95-101.
4. Andersson K-E. Current concepts in the treatment of disorders of micturition. Drugs 1988; 35: 477-494.
5. Andersson K-E. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993; 45: 253-308.
6. Andersson K-E, Larsson B, Persson C. Characterization of the α-adrenoceptors in the female rabbit urethra. Br J Pharmacol 1984; 81: 293-300.
7. Brown M, Wickham JEA. The urethral pressure profile. Br J Urol 1969; 41: 211-217.
8. Callahan SM, Creed KE. The effects of oestrogens on spontaneous activity and responses to phenylephrine of the mammalian urethra. J Physiol (Lond) 1985; 358: 35-46.
9. Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Ann Rev Physiol 1991; 53: 497-508.
10. 2-adrenergic receptor as a model. Vitam Horm 1991; 46: 1-39.
11. Creed KE. Effect of hormones on urethral sensitivity to phenylephrine in normal and incontinent dogs. Res Vet Sci 1983; 34: 177-181.
12. Enhörning G. Simultaneous recording of intravesical and intra-urethral pressure. A study on urethral closure in normal and stress incontinent women. Acta Chir Scand (Suppl) 1961; 276: 1-68.
13. Ghoneim MA, Rottembourg JL, Fretin J, Susset JG. Urethral pressure profile. Standardization of technique and study of reproducibility. Urol 1975; 5: 632-637.
14. Hashimoto S, Kigoshi S, Muramatsu I. Neurogenic responses of urethra isolated from the dog. Eur J Pharmacol 1992; 213: 117-123.
15. 1-adrenoceptor subtype mediating contraction of the smooth muscle in the lower urinary tract and prostate of rabbits. Naunyn-Schmiedebergs Arch Pharmacol 1985; 330: 16-21.
16. Kadar N, Nelson JH. Treatment of urinary incontinence after radical hysterectomy. Obstet Gynecol 1984; 64: 400-405.
17. Khanna OP, Heber D, Gonick P. Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Urol 1975; 5: 616-623.
18. Larsson B, Sjögren C, Andersson K-E. Regional distribution of α-adrenoceptor subtypes in the female rabbit urethra. Acta Physiol Scand 1986; 126: 39-43.
19. Lasagna L. Phenylpropanolamine. A review. New York: John Wiley and Sons, 1988: 1-440.
20. Levin RM, Wein AJ. Quantitative analysis of alpha and beta adrenergic receptor densities in the lower urinary tract of the dog and the rabbit. Inv Urol 1979; 17: 75-77.
21. Levitt M, Cumiskey WR, Shargel L. Studies on the physiologic disposition and activity of phenylpropanolamine in the mouse. Drug Metab Dispos 1974; 2: 187-193.
22. Lohse MJ. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta 1993; 1179: 171-188.
23. Massat BJ, Gregory CR, Ling GV, Cardinet GH, Lewis EL. Cystourethropexy to correct refractory urinary incontinence due to urethral sphincter mechanism incompetence. Preliminary results in ten bitches. Vet Surg 1993; 22: 260-268.
24. 1-adrenergic receptors and contraction of rat vas deferens. Mol Pharmacol 1983; 23: 359-368.
25. 1-adrenergic receptor subtypes. Mol Pharmacol 1994; 46: 929-936.
26. Nishizawa O, Moriya I, Fukuda T, Matsuzaki A, Tsuchida S. Effects of the autonomic antagonists on canine urethral responses to autonomie nerve stimulation. Urol Int 1985; 40: 314-319.
27. Poirier M, Riffaud JP, Lacolle JY, Dupont C. Effects of five alpha-blockers on the hypogastric nerve stimulation of the canine lower urinary tract. J Urol 1988; 140: 165-167.
28. Raz S, Caine M. Adrenergic receptors in the female canine urethra. Inv Urol 1972; 9: 319-323.
29. Raz S, Zeigler M, Caine M. Isometric studies on canine urethral musculature. Inv Urol 1972; 9: 443-446.
30. Recip, Stockholm, Sweden. II E finished product specification. Q04/95. Q09/95.
31. Sjögren C, Tobin G. An experimental model for long-term examinations of urethral and uterine pressures in conscious dogs: effect of a highly selective compound contracting urethral smooth muscles. J Urol 1995; 153: 201-205.
32. Toews ML, Shreve PE, Bylund DB. Regulation of adrenergic receptors. In: Martinez JR, Edwards BS, Seagrave JC, eds. Signalling mechanisms in secretory and immune cells. San Francisco: San Francisco Press, 1991: 1-17.
33. Trendelenburg U. Classification of sympathomimetic amines. Handbook of experimental pharmacology 1972; 33: 336-362.
34. Trendelenburg U, Muskus A, Fleming WW, Gomez Alonso de la Sierra B. Modification by reserpine of the action of sympathomimetic amines in spinal cats: a classification of sympathomimetic amines. J Pharmacol Exp Ther 1962; 138: 170-180.
35. Trendelenburg U, Muskus A, Fleming WW, Gomez Alonso de la Sierra B. Effect of cocaine, denervation and decentralization on the response of the nictitating membrane to various sympathomimetic amines. J Pharmacol Exp Ther 1962; 138: 181-193.
36. Tulloch AGS. The vascular contribution to intraurethral pressure. Br J Urol 1974; 46: 659-664.
37. Vick J, Weiss L, Ellis S. Cardiovascular studies of phenylpropanolamine. Arch Int Pharmacodyn Ther 1994; 327: 13-24.
38. 2-adrenoceptors in the smooth muscle of male and female rabbit urethra. Eur J Pharmacol 1986; 121: 1-8.