Enhanced donor-specific alloreactivity occurs independently of immunosuppression in children with early liver rejection

American Journal of Transplantation

Volumn 5, Issue 1, 2005, Pages 96-102

  Sindhi, Rakesh ^a   Magill, Amy ^a   Bentlejewski, Carol ^a   Abdullah, Ali ^a   Tresgaskes, Mary ^a   Seward, Joseph ^a   Janosky, Janine ^a   Zeevi, Adriana ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Donor specific alloreactivity; Liver transplantation; Lymphocyte response; Pediatric; Rabbit anti thymocyte globulin; Rejection; Tacrolimus

Indexed keywords

CD8 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ADOLESCENT; ALLOGRAFT; ALLOIMMUNITY; ARTICLE; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MALE; PHARMACODYNAMICS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ANIMALS; ANTIGENS; ANTIGENS, CD19; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INFANT; INTERFERON TYPE II; LIVER; LIVER TRANSPLANTATION; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MALE; RABBITS; SPLEEN; STEROIDS; T-LYMPHOCYTES; TACROLIMUS; TIME FACTORS; TISSUE DONORS;

EID: 11844287652     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00639.x     Document Type: Article

References (33)

1. Colombani PM, Lau H, Prabhakaran K et al. Cumulative experience with pediatric living related liver transplantation. J Pediat Surg 2000; 35: 9-12.
2. Heffron TG, Pillen T, Smallwood GA, Welch D, Oakley B, Romero R. Pediatric liver transplantation with daclizumab induction. Transplantation 2003; 75: 2040-2043.
3. Fridell JA, Jain A, Reyes J et al. Causes of mortality beyond one year following primary pediatric liver transplantation under tacrolimus. Transplantation 2002; 74: 1721-1724.
4. Jain A, Reyes J, Kashyap R et al. Primary liver transplantation under tacrolimus in infants, children, adults and seniors: 1000 consecutive cases: Mean follow-up 7 years. Transplant Proc 1998; 30: 1403-1404.
5. Balistreri WF, Bucuvalas JC, Ryckman FC. The effect of immunosuppression on growth and development. Liver Transpl Surg 1997; 1: 64-73.
6. Calne R. Prope tolerance: A step in the search for tolerance in the clinic. Transplant Proc 2000; 32: 2058-2059.
7. Swanson SJ, Hale DA, Mannon RB et al. Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. Lancet 2002; 360 (9346): 1662-1664.
8. Starzl TE et al. Tolerogenic immunosuppression for organ transplantation. Lancet 2003; 361: 1502-1510.
9. Sindhi R, Allaert J, Gladding D, Haaland P, Dunne JF, Sehgal S. Modeling individual variation in biomarker response to combination therapy-potential clinical implications. J Immunol Methods 2003; 272: 257-272.
10. Sindhi R, LaVia MF, Paulling E et al. Intracellular IL-2 response of stimulated peripheral lymphocytes may distinguish cyclosporine effect in renal transplant recipients. Transplantation 2000; 69: 432-436.
11. Sindhi R, Allaert J, Gladding D, Koppelman B, Dunne JF. Cytokines and cell-surface receptors as target endpoints of immunosuppression with cyclosporine A. J Interferon Cytokine Res 2001; 21: 507-514.
12. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis. Concepts and Applications. Swedish Pharmaceutical Press. 1994: 423-579.
13. Kashiwagi N, Corman J, Iwatsuki S et al. Mixed lymphocyte culture and graft rejection. Surg Forum 1973; 24: 345-348.
14. Kerman RH, Susskind B, Katz SM, Van Buren CT, Kahan BD. Postrenal transplant MLR hypo-responders have fewer rejections and better graft survival than MLR hyper-responders. Transplant Proc 1997; 29: 1410-1411.
15. Ingulli E, Sharma V, Singh A, Suthanthiran M, Tejani A. Steroid withdrawal, rejection and the mixed lymphocyte reaction in children after renal transplantation. Kidney Int Suppl 1993; 43: S36-S39.
16. Cardella CJ, Landsberg D, Ng CM. Rejection episodes and lymphocyte responses in patients treated with rabbit antithymocyte sera. Transplant Proc 1984; 16: 1089-1092.
17. Thomsen M, Dickmeiss E. Correlation between mixed lymphocyte culture in compatibility and cadaver kidney graft rejection. Scandinavian J Urol Nephrol Suppl 1977: 40-43.
18. Sindhi R, Magill A, Yost M. Peripheral lymphocyte markers as surrogate measures of immunosuppression and post-transplant states. Clin Appl Immunol Rev 2004; 4: 225-238.
19. Sindhi R, Amy M, Carol B, Adriana Z. Mechanisms of rejection graft adaptation. Human Immunol 2003; 64: S50.
20. Gebauer BS, Hricik DE, Atallah A et al. Evolution of the enzyme-linked immunosorbent spot assay for post-transplant alloreactivity as a potentially useful immune monitoring tool. Am J Transplant 2002; 2: 857-866.
21. Hricik DE, Rodriguez V, Riley J et al. Enzyme-linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients. Am J Transplant 2003; 3: 878-884.
22. Mascher B, Schlenke P, Seyfarth M. Expression kinetics of cytokines determined by intracellular staining using flow cytometry. J Immunol Methods 1999; 223: 115-121.
23. Ahmed M, Venkataramanan R, Logar AJ et al. Quantisation of immunosuppression tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells. Ther Drug Monit 2001; 23: 354-362.
24. Baron ED, Heeger PS, Hricik DE, Schulak JA, Tary-Lehmann M, Stevens SR. Immunomodulatory effect of extracorporeal photopheresis after successful treatment of resistant renal allograft rejection. Photodermatol Photoimmunol Photomed 2001; 17: 79-82.
25. Bingaman AW, Farber DL. Memory T-cells in transplantation: Generation, function and potential role in rejection. Am J Transplant 2004; 4: 853-862.
26. Rizzo M, SivaSai KS, Smith MA et al. Increased expression of inflammatory cytokines and adhesion molecules by alveolar macrophages of human lung allograft recipients with acute rejection: Decline with resolution of rejection. J Heart Lung Transplant 2000; 19: 858-865.
27. Navarro-Zorraquino M, Guemes A, Pastor C et al. Apoptosis and CD8 and CD54 cell expression in rat small bowel transplantation. J Surg Res 2002; 103: 37-40.
28. Roberti I, Reisman L. Serial evaluation of cell surface markers for immune activation after acute renal allograft rejection by urine flow cytometry-Correlation with clinical outcome. Transplantation 2001; 71: 1317-1320.
29. Creemers P, Brink J, Wainwright H, Moore K, Shephard E, Kahn D. Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets, CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection. Transplant Immunol 2002; 10: 285-292.
30. Lagraine C, Lebranchu Y. Effects of immunosuppressive drugs on dendritic cells and tolerance induction. Transplantation 2003; 75: 37S-7542S.
31. Mayer TG, Fuller AA, Fuller TC, Lazarovits AI, Boyle LA, Kurnick JT. Characterization of in vivo-activated allospecific T lymphocytes propagated from human renal allograft biopsies undergoing rejection. J Immunol 1985; 134: 258-264.
32. Zeevi A, Erias G, Kaufman C et al. Correlation between bioassayed plasma levels of FK506 and lymphocyte growth from liver transplant biopsies with histological evidence of rejection. Transplant Proc 1991; 23: 1406-1408.
33. - T-suppressor cells. Human Immunol (In press).