Expression of minichromosome maintenance proteins in Merkel cell carcinoma

Journal of the European Academy of Dermatology and Venereology

Volumn 23, Issue 10, 2009, Pages 1184-1188

  Gambichler, T ^a   Breininger, A ^a   Rotterdam, S ^a   Altmeyer, P ^a   Stucker M ^a   Kreuter, A ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cell cycle regulation; Merkel cell carcinoma; Minichromosome maintenance proteins; Proliferation

Indexed keywords

KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 4; MINICHROMOSOME MAINTENANCE PROTEIN 6; MINICHROMOSOME MAINTENANCE PROTEIN 7; P21 ACTIVATED KINASE;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MELANOMA; MERKEL CELL TUMOR; MINICHROMOSOME; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

AGED; AGED, 80 AND OVER; CARCINOMA, MERKEL CELL; CASE-CONTROL STUDIES; CHROMOSOMES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 70349097249     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2009.03285.x     Document Type: Article

References (24)

1. Quinn CM, Wright NA. The clinical assessment of proliferation and growth in human tumours: evaluation of methods and applications as prognostic variables. J Pathol 1990 160 : 93 102.
2. Tachibana KE, Gonzalez MA, Coleman N. Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J Pathol 2005 205 : 123 129.
3. Ha SA, Shin SM, Namkoong H et al. Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. Clin Cancer Res 2004 10 : 8386 8395.
4. Freeman A, Morris LS, Mills AD et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999 5 : 2121 2132.
5. Padmanabhan V, Callas P, Philips G, Trainer TD, Beatty BG. DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer. J Clin Pathol 2004 57 : 1057 1062.
6. Schrader C, Janssen D, Klapper W et al. Minichromosome maintenance protein 6, a proliferation marker superior to Ki-67 and independent predictor of survival in patients with mantle cell lymphoma. Br J Cancer 2005 93 : 939 945.
7. Gambichler T, Bischoff S, Bechara FG, Altmeyer P, Kreuter A. Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders. J Dermatol Sci 2008 49 : 125 132.
8. Boyd AS, Shakhtour B, Shyr Y. Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases. J Am Acad Dermatol 2008 58 : 750 754.
9. Winnepenninckx V, Lazar V, Michiels S et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst 2006 98 : 472 482.
10. Liu H, Takeuchi S, Moroi Y et al. Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. Int J Dermatol 2007 46 : 1171 1176.
11. Pectasides D, Pectasides M, Economopoulos T. Merkel cell cancer of the skin. Ann Oncol 2006 17 : 1489 1495.
12. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008 319 : 1096 1100.
13. Devoe K, Weidner N. Immunohistochemistry of small round-cell tumors. Semin Diagn Pathol 2000 17 : 216 224.
14. Yiengpruksawan A, Coit DG, Thaler HT et al. Merkel cell carcinoma: prognosis and management. Arch Surg 1991 126 : 1514 1519.
15. Brown DC, Gatter KC. Ki67 protein: the immaculate deception? Histopathology 2002 40 : 2 11.
16. Llombart B, Monteagudo C, López-Guerrero JA et al. Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers. Histopathology 2005 46 : 622 634.
17. Fernández-Figueras MT, Puig L, Musulén E et al. Expression profiles associated with aggressive behavior in Merkel cell carcinoma. Mod Pathol 2007 20 : 90 101.
18. Bickle K, Glass LF, Messina JL, Fenske NA, Siegrist K. Merkel cell carcinoma: a clinical, histopathologic, and immunohistochemical review. Semin Cutan Med Surg 2004 23 : 46 53.
19. Koljonen V, Tukiainen E, Haglund C, Böhling T. Cell cycle control by p21, p27 and p53 in Merkel cell carcinoma. Anticancer Res 2006 26 : 2209 2212.
20. Benjamin CL, Melnikova VO, Ananthaswamy HN. P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer. Adv Exp Med Biol 2008 624 : 265 282.
21. Gartel AL, Radhakrishnan SK. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005 65 : 3980 3985.
22. Feinmesser M, Halpern M, Fenig E et al. Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: can they predict treatment response and clinical outcome? Hum Pathol 1999 30 : 1367 1372.
23. Tucci MG, Lucarini G, Giangiacomi M et al. Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinoma. J Eur Acad Dermatol Venereol 2006 20 : 1220 1225.
24. Lei M. The MCM complex: its role in DNA replication and implications for cancer therapy. Curr Cancer Drug Targets 2005 5 : 365 380.