Transient expression of ephrin B2 in perinatal skin is required for maintenance of keratinocyte homeostasis

Journal of Investigative Dermatology

Volumn 129, Issue 10, 2009, Pages 2386-2395

  Egawa, Gyohei ^a,b   Osawa, Masatake ^a,c   Uemura, Akiyoshi ^a   Miyachi, Yoshiki ^b   Nishikawa, Shin Ichi ^a  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; INTERLEUKIN 1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DERMIS; EMBRYO DEVELOPMENT; EPIDERMIS CELL; HOMEOSTASIS; KERATINOCYTE; MESENCHYME CELL; MICROENVIRONMENT; MORPHOGENESIS; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; TRANSIENT EXPRESSION;

ANIMALS; ANIMALS, NEWBORN; CELL PROLIFERATION; EPHRIN-B2; HOMEOSTASIS; INTERLEUKIN-1; KERATINOCYTES; MESODERM; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MORPHOGENESIS; SKIN;

EID: 70349095279     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.105     Document Type: Article

References (34)

1. Andl T, Reddy ST, Gaddapara T, Millar SE (2002) WNT signals are required for the initiation of hair follicle development. Dev Cell 2:643-653
2. Atit R, Conlon RA, Niswander L (2003) EGF signaling patterns the feather array by promoting the interbud fate. Dev Cell 4:231-240
3. Barrios A, Poole RJ, Durbin L, Brennan C, Holder N, Wilson SW (2003) Eph/ Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis. Curr Biol 13:1571-1582
4. Bedogni B, Welford SM, Cassarino DS, Nickoloff BJ, Giaccia AJ, Powell MB (2005) The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell 8:443-454
5. Bigler CF, Norris DA, Weston WL, Arend WP (1992) Interleukin-1 receptor antagonist production by human keratinocytes. J Invest Dermatol 98:38-44
6. Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N et al. (2007) Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med 204:2603-2614
7. Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W et al. (1999) Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol 1:158-164
8. DasGupta R, Fuchs E (1999) Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126:4557-4568
9. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127:4775-4785
10. Dottori M, Hartley L, Galea M, Paxinos G, Polizzotto M, Kilpatrick T et al. (1998) EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci USA 95:13248-13253
11. Dravis C, Yokoyama N, Chumley MJ, Cowan CA, Silvany RE, Shay J et al. (2004) Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol 271:272-290
12. Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N et al. (2006) Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124:161-173
13. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE et al. (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogen-esis. Neuron 17:9-19
14. Gat U, DasGupta R, Degenstein L, Fuchs E (1998) De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95:605-614
15. Gerety SS, Anderson DJ (2002) Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development 129:1397-1410
16. Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999) Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 4:403-414
17. Guo H, Miao H, Gerber L, Singh J, Denning MF, Gilliam AC et al. (2006) Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res 66:7050-7058
18. Hafner C, Becker B, Landthaler M, Vogt T (2006) Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol 19:1369-1377
19. Hickey MM, Simon MC (2006) Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol 76:217-257
20. Jung HS, Francis-West PH, Widelitz RB, Jiang TX, Ting-Berreth S, Tickle C et al. (1998) Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning. Dev Biol 196:11-23
21. le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R et al. (2004) Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development 131:361-375
22. Mackenzie MA, Jordan SA, Budd PS, Jackson IJ (1997) Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev Biol 192:99-107
23. Metzger D, Chambon P (2001) Site- and time-specific gene targeting in the mouse. Methods 24:71-80 Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H et al. (2006) Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173:333-339
24. Noramly S, Morgan BA (1998) BMPs mediate lateral inhibition at successive stages in feather tract development. Development 125:3775-3787
25. Palmer A, Klein R (2003) Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes Dev 17:1429-1450
26. Pasquale EB (2004) Eph-ephrin promiscuity is now crystal clear. Nat Neurosci 7:417-8
27. Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6:462-475
28. Santiago A, Erickson CA (2002) Ephrin-B ligands play a dual role in the control of neural crest cell migration. Development 129:3621-3632
29. Smith A, Robinson V, Patel K, Wilkinson DG (1997) The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr Biol 7:561-570
30. St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS et al. (1998) Sonic hedgehog signaling is essential for hair development. Curr Biol 8:1058-1068
31. Wang HU, Chen ZF, Anderson DJ (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93:741-753
32. Wang X, Seed B (2003) A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res 31:e154
33. Zhang Y, Riesterer C, Ayrall AM, Sablitzky F, Littlewood TD, Reth M (1996) Inducible site-directed recombination in mouse embryonic stem cells. Nucleic Acids Res 24:543-548
34. Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T et al. (2006) Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 4:111-121