Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway

Acta Biomaterialia

Volumn 5, Issue 8, 2009, Pages 3258-3264

  Yang, Rong Sen ^a   Tzeng, Huei Ping ^a   Ho, Feng Ming ^b   Chuang, Chia Chi ^a   Chen, Bo Lin ^a   Huang, Chun Fa ^c   Chen, Ya Wen ^d   Chen, Ruei Ming ^e   Liu, Shing Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aorta; Endothelial cells; eNOS; Titanium alloy implants

Indexed keywords

BLOOD VESSELS; ENDOTHELIAL CELLS; ENZYME ACTIVITY; IMPLANTS (SURGICAL); KNEE PROSTHESES; NITRIC OXIDE; PHOSPHORYLATION; RATS;

ENDOTHELIAL FUNCTION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIAL-CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; PROTEIN EXPRESSIONS; PROTEIN KINASES C; TITANIA; TITANIA ALLOY IMPLANT; TITANIUM (ALLOYS); TITANIUM IMPLANTS;

TITANIUM ALLOYS;

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; TITANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMPLANT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE CONTRACTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

RATTUS;

ANIMALS; CELL LINE; ENDOTHELIUM, VASCULAR; HUMANS; MATERIALS TESTING; MICE; PROSTHESES AND IMPLANTS; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; TITANIUM; VASOCONSTRICTION;

EID: 70349094424     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2009.05.006     Document Type: Article

References (29)

1. Dorr L.D., Bloebaum R., Emmanual J., and Meldnum R. Histologic, biochemical, and ion analysis of tissue and fluids retrieved during total hip arthroplasty. Clin Orthop Relat Res 261 (1990) 82-95
2. Maloney Wj., and Smith Rl. Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris. J Bone Joint Surg 77A (1995) 1448-1461
3. Urban R.M., Jacobs J.J., Tomlinson M.J., Gavrilovic J., Black J., and Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg Am 82 (2000) 457-476
4. Urban R.M., Tomlinson M.J., Hall D.J., and Jacobs J.J. Accumulation in liver and spleen of metal particles generated at nonbearing surfaces in hip arthroplasty. J Arthroplasty 19 Suppl. 3 (2004) 94-101
5. Coleman R.F., Herrington J., and Scales J.T. Concentration of wear products in hair, blood, and urine after total hip replacement. BMJ 1 (1973) 527-529
6. Kasai Y., Iida R., and Uchida A. Metal concentrations in the serum and hair of patients with titanium alloy spinal implants. Spine 28 (2003) 1320-1326
7. Liu T.K., Liu S.H., Chang C.H., and Yang R.S. Concentration of metal elements in the blood and urine in the patients with cementless total knee arthroplasty. Tohoku J Exp Med 185 (1998) 253-262
8. Yang R.S., Tsai K.S., and Liu S.H. Titanium implants enhance pulmonary nitric oxide production and lung injury in rats exposed to endotoxin. J Biomed Mater Res A 69 (2004) 561-566
9. Ignarro L.J., Cirino G., Casini A., and Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 34 (1999) 879-886
10. Feletou M., Tang E.H., and Vanhoutte P.M. Nitric oxide the gatekeeper of endothelial vasomotor control. Front Biosci 13 (2008) 4198-4217
11. Tzeng H.P., Yang R.S., Ueng T.H., Lin-Shiau S.Y., and Liu S.H. Motorcycle exhaust particulates enhance vasoconstriction in organ culture of rat aortas and involve reactive oxygen species. Toxicol Sci 75 (2003) 66-73
12. Sheu M.L., Ho F.M., Yang R.S., Chao K.F., Lin W.W., Lin-Shiau S.Y., et al. High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway. Arterioscler Thromb Vasc Biol 25 (2005) 539-545
13. Sheu M.L., Chiang C.K., Tsai K.S., Ho F.M., Weng T.I., Wu H.Y., et al. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Free Radic Biol Med 44 (2008) 2043-2050
14. Xu J., Yeh C.H., Chen S., He L., Sensi S.L., Canzoniero L.M.T., et al. Involvement of de novo ceramide biosynthesis in tumor necrosis factor-α/cycloheximide-induced cerebral endothelial cell death. J Biol Chem 273 (1998) 16521-16526
15. Dobbs H.S., and Minski M.J. Metal ion release after total hip replacement. Biomaterials 1 (1980) 193-198
16. Pazzaglia U.E., Minoia C., Gualtieri G., Gualtieri I., Riccardi C., and Ceciliani L. Metal ions in body fluids after arthroplasty. Acta Orthop Scand 57 (1986) 415-419
17. Luetzner J., Krummenauer F., Lengel A.M., Ziegler J., and Witzleb W.C. Serum metal ion exposure after total knee arthroplasty. Clin Orthop Relat Res 461 (2007) 136-142
18. Langkamer V.G., Case C.P., Heap P., Taylor A., Collins C., Pearse M., et al. Systemic distribution of wear debris after hip replacement. J Bone Joint Surg 74B (1992) 831-839
19. Salvati E.A., Betts F., and Doty S.B. Particulate metallic debris in cemented total hip arthroplasty. Clin Orthop Relat Res 293 (1993) 160-173
20. Kumazawa R., Watari F., Takashi N., Tanimura Y., Uo M., and Totsuka Y. Effects of Ti ions and particles on neutrophil function and morphology. Biomaterials 23 (2002) 3757-3764
21. Jacobs J.J., Skipor A.K., Patterson L.M., Hallab N.J., Paprosky W.G., Black J., et al. Metal release in patients who have had a primary total hip arthroplasty. J Bone Joint Surg Am 80 (1998) 1447-1458
22. Richardson T.D., Pineda S.J., Strenge K.B., Van Fleet T.A., MacGregor M., Milbrandt J.C., et al. Serum titanium levels after instrumented spinal arthrodesis. Spine 33 (2008) 792-796
23. Fulton D., Ruan L., Sood S.G., Li C., Zhang Q., and Venema R.C. Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation: role of eNOS phosphorylation at Tyr83. Circ Res 102 (2008) 497-504
24. Napoli C., de Nigris F., Williams-Ignarro S., Pignalosa O., Sica V., and Ignarro L.J. Nitric oxide and atherosclerosis: an update. Nitric oxide 15 (2006) 265-279
25. Ignarro L.J., and Napoli C. Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis. Curr Atheroscler Rep 6 (2004) 281-287
26. Dimmeler S., Dernbach E., and Zeiher A.M. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett 477 (2000) 258-262
27. Bauer P.M., Fulton D., Boo Y.C., Sorescu G.P., Kemp B.E., Jo H., et al. Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem 278 (2003) 14841-14849
28. Partovian C., Zhuang Z., Moodie K., Lin M., Ouchi N., Sessa W.C., et al. PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res 97 (2005) 482-487
29. Chen D.B., Bird I.M., Zheng J., and Magness R.R. Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology 145 (2004) 113-125