Transepithelial activation of human leukocytes by probiotics and commensal bacteria: Role of Enterobacteriaceae-type endotoxin

Microbiology and Immunology

Volumn 53, Issue 4, 2009, Pages 241-250

  Baeuerlein, Annette ^a   Ackermann, Stefanie ^a   Parlesak, Alexandr ^b  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Commensals; Endotoxin; Probiotics; Transepithelial leukocyte activation

Indexed keywords

ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; PROBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ARTICLE; BACTEROIDES VULGATUS; BIFIDOBACTERIUM; CONTROLLED STUDY; DRUG ACTIVITY; ENTEROBACTERIACEAE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LACTOBACILLUS; LEUKOCYTE; LEUKOCYTE ACTIVATION; NONHUMAN; CELL CULTURE; CELL STRAIN CACO 2; COCULTURE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; SECRETION;

BACTERIA (MICROORGANISMS); BACTEROIDES VULGATUS; BIFIDOBACTERIUM; ENTEROBACTERIACEAE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; LACTOBACILLUS; NEGIBACTERIA; POSIBACTERIA; SALMONELLA ENTERICA;

CACO-2 CELLS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; ENDOTOXINS; ENTEROBACTERIACEAE; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PROBIOTICS;

EID: 70249150373     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00119.x     Document Type: Article

References (36)

1. McFarland L.V. (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101: 812-22.
2. Cross M.L. (2002) Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens. FEMS Immunol Med Microbiol 34: 245-53.
3. Moorthy G., Murali M.R., Devaraj S.N. (2007) Protective role of lactobacilli in Shigella dysenteriae 1-induced diarrhea in rats. Nutrition 23: 424-33.
4. Bianchi M.E. (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1-5.
5. Barton G.M. (2008) A calculated response: control of inflammation by the innate immune system. J Clin Invest 118: 413-20.
6. Fritz J.H., Le Bourhis L., Magalhaes J.G., Philpott D.J. (2008) Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat. Trends Immunol 29: 41-9.
7. Xu D., Komai-Koma M., Liew F.Y. (2005) Expression and function of Toll-like receptor on T cells. Cell Immunol 233: 85-9.
8. Kabelitz D., Medzhitov R. (2007) Innate immunity-cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol 19: 1-3.
9. Sartor R.B. (2005) Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol 21: 44-50.
10. Haller D., Bode C., HammesW.P., Pfeifer A.M., Schiffrin E.J., Blum S. (2000) Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 47: 79-87.
11. Parlesak A., Haller D., Brinz S., Baeuerlein A., Bode C. (2004) Modulation of cytokine release by differentiated CACO-2 cells in a compartmentalized coculture model with mononuclear leucocytes and nonpathogenic bacteria. Scand J Immunol 60: 477-85.
12. Westphal O., Jann K. (1965) Bacterial lipopolysaccharides - extraction with phenol-water and further applications of the procedure. In:Whistler R.L., ed. Methods in Carbohydrate Chemistry. New York: Academic Press, pp. 83-91.
13. Fomsgaard A., Freudenberg M.A., Galanos C. (1990) Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels. J Clin Microbiol 28: 2627-31.
14. Parlesak A., Diedrich J.P., Schäfer C., Bode C. (1998) A low concentration of ethanol reduces the chemiluminescence of human granulocytes and monocytes but not the tumor necrosis factor alpha production by monocytes after endotoxin stimulation. Infect Immun 66: 2809-13.
15. Krüger T., Sigsgaard T., Bonefeld-Jørgensen E.C. (2004) Ex vivo induction of cytokines by mould components in whole blood of atopic and non-atopic volunteers. Cytokine 25: 73-84.
16. Munford R.S., Hall C.L., Rick P.D. (1980) Size heterogeneity of Salmonella typhimurium lipopolysaccharides in outer membranes and culture supernatant membrane fragments. J Bacteriol 144: 630-40.
17. Akira S., Uematsu S., Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
18. Zeuthen L.H., Fink L.N., Frokiaer H. (2008) Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. Immunology 123: 197-208.
19. Morath S., Stadelmaier A., Geyer A., Schmidt R.R., Hartung T. (2002) Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release. J Exp Med 195: 1635-40.
20. Keller R., Fischer W., Keist R., Bassetti S. (1992) Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids. Infect Immun 60: 3664-72.
21. Ginsburg I. (2002) Role of lipoteichoic acid in infection and inflammation. Lancet Infect Dis 2: 171-9.
22. Cario E., Gerken G., Podolsky D.K. (2007) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132: 1359-74.
23. Zähringer U., Lindner B., Rietschel E.T. (1999) Chemical structure of lipid A: recent advances in structural analysis of biologically active molecules. In:Brade H., Opal S.M., Vogel S.N., Morrison D.C., eds. Endotoxin in health and disease. New York: Marcel Dekker, pp. 93-114.
24. Lindberg A.A., Weintraub A., Zähringer U., Rietschel E.T. (1990) Structure-activity relationships in lipopolysaccharides of Bacteroides fragilis. Rev Infect Dis 12(Suppl 2): S133-S41.
25. Rietschel E.T., Kirikae T., Schade F.U., Mamat U., Schmidt G., Loppnow H., Ulmer A.J., Zähringer U., Seydel U., Di Padova F., Schreier M., Brade H. (1994) Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J 8: 217-25.
26. Müuller-Loennies S., Zähringer U., Seydel U., Kusumoto S., Ulmer A.J., Rietschel E.T. (1998) What we know and don't know about the chemical and physical structure of lipopolysaccharide in relation to biological activity. Prog Clin Biol Res 397: 51-72.
27. Macfarlane G.T. McBain A. (1999) The human colonic microbiota. In:Gibson G.R., Roberfroid M.B., eds. Colonic microbiota, nutrition and health. Doordrecht: Kluwer Academic Publishers, pp. 1-25.
28. Kruis W., Fric P., Pokrotnieks J., Lukás M., Fixa B., Kascák M., Kamm M.A., Weismueller J., Beglinger C., Stolte M., Wolff C., Schulze J. (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53: 1617-23.
29. Zyrek A.A., Cichon C., Helms S., Enders C., Sonnenborn U., Schmidt M.A. (2007) Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 9: 804-16.
30. Parlesak A., Schaeckeler S., Moser L., Bode C. (2007) Conjugated primary bile salts reduce permeability of endotoxin through intestinal epithelial cells and synergize with phosphatidylcholine in suppression of inflammatory cytokine production. Crit Care Med 35: 2367-74.
31. Haller D., Holt L., Parlesak A., Zanga J., Bäuerlein A., Sartor R.B., Jobin C. (2004) Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells. Immunology 112: 310-20.
32. Steininger R., Roth E., Függer R., et al. (1994) Transhepatic metabolism of TNF-alpha, IL-6, and endotoxin in the early hepatic reperfusion period after human liver transplantation. Transplantation 58: 179-83.
33. Deitch E.A., Xu D., Naruhn M.B., Deitch D.C., Lu Q., Marino A.A. (1995) Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg 221: 299-307.
34. Oudemans-van Straaten H.M., Jansen P.G., Hoek F.J., van Deventer S.J., Sturk A., Stoutenbeek C.P., Tytgat G.N., Wildevuur C.R., Eysman L. (1996) Intestinal permeability, circulating endotoxin, and postoperative systemic responses in cardiac surgery patients. J Cardiothorac Vasc Anesth 10: 187-94.
35. Parlesak A., Schäfer C., Schütz T., Bode J.C., Bode C. (2000) Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 32: 742-7.
36. Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., Neyrinck A.M., Fava F., Tuohy K.M., Chabo C.,Waget A., Delmée E., Cousin B., Sulpice T., Chamontin B., Ferrières J., Tanti J.F., Gibson G.R., Casteilla L., Delzenne N.M., Alessi M.C., Burcelin R. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56: 1761-72.