Lactulose versus polyethylene glycol for chronic constipation

Cochrane Database of Systematic Reviews

Volumn , Issue 1, 2009, Pages

  Lee Robichaud, Heather ^a   Thomas, Kathryn ^a   Morgan, Jenna ^a   Nelson, Richard L ^a  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIS OIL; BISACODYL; DOCUSATE SODIUM; ISPAGULA; LACTULOSE; MACROGOL; MAGNESIUM HYDROXIDE; MAGNESIUM SALT; MINERAL OIL; SENNA EXTRACT;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ABDOMINAL DISTENSION; ABDOMINAL PAIN; ANUS FISSURE; ASPIRATION PNEUMONIA; ATONIC COLON; BLOATING; CLINICAL PROTOCOL; COLIC; COLOSTOMY; CONSTIPATION; CROHN DISEASE; DEPRESSION; DIARRHEA; DIETARY FIBER; DISTRESS SYNDROME; DYSPHAGIA; ENTERITIS; EXERCISE; FECES IMPACTION; FLATULENCE; GALACTOSEMIA; GASTROINTESTINAL OBSTRUCTION; GRANULOMATOUS INFLAMMATION; HEMORRHOID; HUMAN; HYDRATION; HYPOKALEMIA; ILEOSTOMY; INTESTINE FLORA; INTESTINE MOTILITY; INTESTINE OBSTRUCTION; INTESTINE PERFORATION; IRRITABLE COLON; LIFESTYLE MODIFICATION; MALAISE; MOOD CHANGE; NAUSEA; PAINFUL DEFECATION; PARALYTIC ILEUS; PERISTALSIS; QUALITY OF LIFE; REVIEW; SIDE EFFECT; STOMACH PH; SYSTEMATIC REVIEW; TOXIC MEGACOLON; TREATMENT CONTRAINDICATION; ULCERATIVE COLITIS;

EID: 70249136824     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD007570     Document Type: Review

References (45)

1. Arce DA, Ermocilla CA, Costa H. Evaluation of constipation. Am Fam Physician 2002;65:2283-2290.
2. Attar A, Lacmann M, et al.Comparison of low dose PEG electrolyte solution with Lactulose for treatment of chronic constipation. Gut 1999;44(2):226-230
3. Bassotti G, Chistolini F, Marinozzi G, Morelli A. Abnormal colonic propagated activity in patients with slow transit constipation and constipation-predominant irritable bowel syndrome. Digestion 2003;68:178-183.
4. Bassotti G, Bellini M, Pucciani F, et al.An extended assessment of bowel habits in a general population. World J Gastroenterol 2004;10:713-716
5. Bleser S, Brunton S, Carmichael B, Olden K, Rasch R, Steege J. Management of chronic constipation: recommendations from the consensus panel.. J Fam Pract 2005;54(8):691-698
6. British National Formulary. In: John Martin, Dinesh Mehta editor (s). British Medical Association. Royal Pharmaceutical Society of Great Britain. Vol. 54, London: BMJ Publishing Group LTD, RPS Publishing, September 2007:61.
7. Bouhnik Y, Neut C, et al.Prospective randomised parallel-group trial to evaluate the effects of Lactulose and PEG 4000 on colonic flora in chronic idiopathic constipation. Aliment Pharmacol Ther 2004;19(8):889-899
8. Brandt LJ, Schoenfeld P, Prather CM, Quigley EMM, Schiller LR, Talley NJ. Evidenced-based position statement on the management of chronic constipation in North America. Am J Gastroenterol 2005;100(suppl):S1-S21.
9. Candy DC, Edwards D, Geraint M. Treatement of faecal impaction with PEG+E followed by a double-blind comparison of PEG+E versus Lactulose as maintenance therapy. J Pediatr Gastroenterol Nutr 2006;43(1):65-70.
10. Christie AH, Culbert P, Guest JF. Economic impact of low dose PEG 3350 plus electrolytes compared with Lactulose in the management of idiopathic constipation in the UK. Pharmacoeconomics 2002;20(1):49-60.
11. Damon H, Dumas P, Mion F. Impact of anal incontinence and chronic constipation on quality of life. Gastroenterol Clin Biol 2004;28:16-20.
12. Dennison C, Prasad M, Lloyd A, Bhattacharyya SK, Dhawan R, Coyne K. The health-related quality of life and economic burden of constipation. Pharmaco Economics 2005;23:461-476.
13. Drossman DA, Whitehead WE, Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 1997;112:2120-2137.
14. Dupont 2005 Dupont C, et al.Double-blind randomized evaluation of clinical and biological tolerance of PEG 400 vs Lactulose in constipated children. J Pediatr Gastroenterol Nutr 2005;41(5):625-633
15. Ferguson A, Culbert P, Gillett H, Barras N. New PEG electrolyte solution for the treatment of constipation and faecal impaction. Italian Journal of Gastroenterology and hepatology 1999;31(Suppl 3):S249-52.
16. Freedman MD, Schwartz HJ, Roby R, Fleisher S. Tolerance and efficacy of PEG 3350 vs Lactulose in relieving opiate inuced constipation: a double blind placebo controlled trial. J Clin Pharmacol 1997;37(10):904-907
17. Frexinos J, Denis P, Allemand H, Allouche S, Los F, Bonnelye G. Descriptive study of digestive functional symptoms in the French general population. Gastroenterol Clin Biol 1998;22(10):785-791
18. Fritz E, Hammer HF, Lipp RW, Hogenauer C, Stauber R, Hammer J. Effects of Lactulose and PEG on colonic transit. Aliment Pharmacol Ther 2005;21(3):259-268
19. Glia A, Lindberg G. Quality of life in patients with different types of functional constipation. Scand J Gastroenterol 1997;32:1083-1089.
20. Gremse DA, Hixon J, Crutchfield A. Comparison of PEG 3350 and Lactulose for treatment of chronic constipation in children. Clin Pediatr (Phila) 2002;41(4):225-229
21. Guest JF, Varney SJ. Pharmacoeconomic impact of low dose macrogol 3350 plus electrolytes with Lactulose in the management of chronic idiopathic constipation. Clinical Drug investigation 2004;24(12):719-729.
22. Guiraldes E. Pediatric gastroenterology in Chile - a personal perspective. J Pediatr Gastroenterology Nutr 2002;33:231-232
23. Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004;99:750-759.
24. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0. 5.0.0. The Cochrane Collaboration, 2008, updated February 2008.
25. Irvine EJ, Ferrazzi S, Pare P, Thompson WG, Rance L. Health-related quality of life in functional GI disorders: focus on constipation and resource utilization. Am J Gastroenterol 2002;97:1986-1993.
26. Johanson JF, Sonnenberg A, Koch TR. Clinical epidemiology of chronic constipation. J Clin Gastroenterol 1989;11:525-536.
27. Legoretta A, Clark S, Marehbian J, et al.Symptoms associated with chronic gastrointestinal disorders interfere with daily living as assessed by patient reported outcomes in the primary care setting. Am J Gastroenterol 2006;101:S490.
28. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360-1368.
29. Loening-Baucke V. Constipation in early childhood: patient characteristics, treatment, and long-term follow-up. Gut 1993;34:1400-1404
30. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006;130:1480-1491.
31. Mangin I, Bouhnik Y, Suau A, Rochet V, Raskine L, Crenn P, Dyard F, Rambaud JC, Dore J. Molecular analysis of intestinal microbiota composition to evaluate the effect of PEG and Lactulose laxatives in humans. Microbial Ecology in health and disease 2002;14(1):54-62.
32. George Peppas, Vangelis G. Alexiou1, Eleni Mourtzoukou, Matthew E. Falagas. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterology 2008 2008;8:5.
33. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation. Am J Gastroenterol 2005;100(4):936-971
34. Rao SS. Constipation: evaluation and treatment. Gastroenterol Clin North Am 2003;32:659-683.
35. Rendeli C, Ausili E, Tabacco F, focarelli B, Pantanella A, Di Rocco C, Genovese O, Fundara C. PEG 4000 vs. Lactulose for the treatement of neurogenic constipation in myelomeningocele children: a RCT. Aliment Pharmacol Ther 2006;23(8):1259-1265
36. Sandler RS, Drossman DA. Bowel habits in young adults not seeking health care. Dig Dis Sci 1987;32:841-845.
37. Schiller LR, Dennis E, Toth G. An Internet-based survey of the prevalence and symptom spectrum of chronic constipation. Am J Gastroenterol 2004;99:S234.
38. Singh G, Kahler K, Bharathi V, Mithal A, Omar M, Triadafilopoulos G. Adults with chronic constipation have significant healthcare resource utilization and costs of care. Am J Gastroenterol 2004;99:S227.
39. Sondheimer J. Constipation: is there a new approach?. J Pediatr Gastroenterol Nutr 2002;34:357-358
40. Talley NJ, Weaver AL, Zinsmeister AR, Melton LJ III. Functional constipation and outlet delay: a population-based study. Gastroenterology 1993;105:781-790.
41. Talley NJ, Jones M, Nuyts G, Dubois D. Risk factors for chronic constipation based on a general practice sample. Am J Gastroenterol. 2003;98:1107-1111.
42. Talley NJ. Definitions, epidemiology, and impact of chronic constipation. Rev Gastroenterol Disord 2004;4(2):S3-S10.
43. Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999;45(suppl II):II43-II47.
44. Velio P, Bassotti G. Chronic idiopathic constipation: pathophysiology and treatment. J Clin Gastroenterol 1996;22:190-196.
45. Voskuiji W, de Lorijn F, et al.PEG3350 versus Lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled multi-centre trial. Gut 2004;53(11):1590-1594