Pharmacoeconomic impact of low-dose macrogol 3350 plus electrolytes compared with lactulose in the management of chronic idiopathic constipation among ambulant patients in Belgium

Clinical Drug Investigation

Volumn 24, Issue 12, 2004, Pages 719-729

  Guest, Julian F ^a   Varney, Susan J ^a  

^a CATALYST Health Economics Consultants   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROLYTE; LACTULOSE; MACROGOL 3350;

ARTICLE; BELGIUM; CONSTIPATION; COST EFFECTIVENESS ANALYSIS; DRUG WITHDRAWAL; GENERAL PRACTITIONER; HEALTH CARE UTILIZATION; HUMAN; LONG TERM CARE; LOW DRUG DOSE; MEDICAL SPECIALIST; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIDE EFFECT; UNITED KINGDOM;

EID: 10844277390     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200424120-00003     Document Type: Article

References (22)

1. Barloon T, Lu C. Diagnostic imaging in the evaluation of constipation in adults. Am Fam Physician 1997; 56 (2): 513-20
2. Ross H. Constipation: cause and control in an acute hospital setting. Br J Nurs 1998; 7 (15): 907-13
3. Powell M, Davies C. Constipation: a management overview. Audit of chronic constipation in the community. London: Professional Medical Communications Ltd, 1999: 1-5
4. Kinnunen O, Winblad I, Koistinen P, et al. Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients. Pharmacology 1993; 47 Suppl. 1: 253-5
5. Intercontinential Medical Statistics (IMS). London: 1991
6. Verhaeghe J, Jaecques N, Rombouts J, et al. Functional dyspepsia versus other functional gastrointestinal disorders: a practical approach in Belgian general practices. Scand J Gastroenterol 1993; 195: 25-34
7. Health Care Systems in Transition: Belgium, 2000. European Observatory on Health Care Systems. Copenhagen: WHO Regional Office for Europe,
8. Christie AH, Culbert P, Guest JF. The economic impact of low dose polyethylene glycol 3350 plus electrolytes compared to lactulose in the management of idiopathic constipation in the UK. Pharmacoeconomics 2002; 20 (1): 49-60
9. Attar A, Lémann M, Ferguson A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 1999; 44: 226-30
10. National Institute for Sickness and Invalidity Insurance (IN-AMI/RIZIV). Brussels 2002
11. Lederle F. Epidemiology of constipation in elderly patients: drug utilisation and cost-containment strategies. Drugs Aging 1995; 6 (6): 465-9
12. Tramonte S, Brand M, Mulrow C, et al. The treatment of chronic constipation in adults: a systematic review. J Gen Intern Med 1997; 12: 15-24
13. Sweeney M. Constipation: diagnosis and treatment. Home Care Provid 1997; 2 (5): 250-5
14. Weinstein MC, Fineberg HV. Clinical decision analysis. Philadelphia: WB Saunders Co., 1980: 228-65
15. Denis P, Teillet L, Moulias R-L. Tolérance et efficacité du Forlax: Étude comparative versus lactulose au long cours chez des patients souffrant de constipation functionnelle. Act Med Int Gastro-enterologie 1996; 10 Suppl. 2: 3-14
16. Couturier D, Licht H. Etude comparative de l'efficacité de Forlax versus lactulose dans le traitement de la constipation fonctionnelle de l'adulte. Gastroenterologie 1996; 105: 21-4
17. Fleurie B. Treatment of constipation by macrogol 3350: preliminary study on healthy volunteers (the impact of the concentration and method of administration of the solution on the weight and osmolarity of stools). Norgine Ltd, 1991 (data on file)
18. Lémann M, Chaussade S, Halphen M, et al. Low dose polyethylene glycol in chronic constipation: double-blind placebo-controlled crossover trial [abstract]. Gastroenterology 1996; 110: A704
19. Bouhnik Y, Neut C, Raskine L, et al. Prospective, randomized, parallel-group trial to evaluate the effects of lactulose and polyethylene glycol-4000 on colonie flora in chronic idiopathic constipation. Aliment Pharmacol Ther 2004; 19 (8): 889-99
20. Passmore A. Economic aspects of pharmacotherapy for chronic constipation. Pharmacoeconomics 1995; 7 (1): 14-24
21. Lederle FA, Busch DL, Mattox KM, et al. Cost-effective treatment of constipation in the elderly: a randomized double-blind comparison of sorbitol and lactulose. Am J Med 1990; 89 (5): 597-601
22. Frank L, Kleinman L, Farup L, et al. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol 1999; 34: 870-7