Efficacy and safety of traditional medical therapies for chronic constipation: Systematic review

American Journal of Gastroenterology

Volumn 100, Issue 4, 2005, Pages 936-971

  Ramkumar, Davendra ^a   Rao, Satish S C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; AGIOLAX; ALOE VERA EXTRACT; ANTHRAQUINONE DERIVATIVE; BISACODYL; BISOXATIN ACETATE; CHELIDONIUM EXTRACT; CISAPRIDE; CODANTHRAMER; COLCHICINE; DOCUSATE CALCIUM; DOCUSATE SODIUM; ENEMA; ERYTHROMYCIN; ISPAGULA; LACTULOSE; LAXATIVE; LOXIGLUMIDE; LUNELAX; MACROGOL; MACROGOL 3350; MACROGOL 4000; MAGNESIUM HYDROXIDE; MAGNESIUM SULFATE; METHYLCELLULOSE; MISOPROSTOL; PICOSULFATE SODIUM; POLOXAMER; POLYCARBOPHIL CALCIUM; SENNA EXTRACT; SENOKOT; SORBITOL; TEGASEROD; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABDOMINAL PAIN; ARTICLE; BLOATING; BLOOD CELL COUNT; CLINICAL TRIAL; CONSTIPATION; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DIET SUPPLEMENTATION; DIZZINESS; DRUG COST; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; EPIGASTRIC PAIN; FLATULENCE; GASTROINTESTINAL SYMPTOM; HEADACHE; HIGH FIBER DIET; HUMAN; HYPERMAGNESEMIA; INCONTINENCE; INTESTINE DISTENSION; INTESTINE TRANSIT TIME; LOW DRUG DOSE; MUSCLE CRAMP; NAUSEA; OUTCOMES RESEARCH; PANCREAS INSUFFICIENCY; PLANT FIBER; PNEUMATOSIS INTESTINALIS; PRIORITY JOURNAL; RHINOPHARYNGITIS; STOMACH DISEASE; SYSTEMATIC REVIEW; TASTE DISORDER; TRADITIONAL MEDICINE; URINALYSIS; VOMITING; WHEAT BRAN; ADULT; AGED; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; EVIDENCE BASED MEDICINE; META ANALYSIS; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; REVIEW; TREATMENT OUTCOME;

ADULT; AGED; CATHARTICS; CHRONIC DISEASE; CONSTIPATION; EVIDENCE-BASED MEDICINE; HUMANS; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 17544361897     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.40925.x     Document Type: Article

References (71)

1. Thompson WG, Heaton KW. Functional bowel disorders in apparently healthy people. Gastroenterology 1980;79:283-8.
2. Talley NJ, Weaver AL, Zinsmeister AR, et al. Functional constipation and outlet delay: A population-based study. Gastroenterology 1993;105:781-90.
3. Drossman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80.
4. Johanson JF, Sonnenberg A, Koch TR. Clinical epidemiology of chronic constipation [comment]. J Clin Gastroenterol 1989;11:525-36.
5. Harari D, Gurwitz JH, Minaker KL. Constipation in the elderly [comment]. J Am Geriatr Soc 1993;41:1130-40.
6. Jones MP, Talley NJ, Nuyts G, et al. Lack of objective evidence of efficacy of laxatives in chronic constipation. Dig Dis Sci 2002;47:2222-30.
7. Schoenfeld P, Cook D, Hamilton F, et al. An evidence-based approach to gastroenterology therapy. Evidence-Based Gastroenterology Steering Group. Gastroenterology 1998;114:1318-25.
8. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996;17:1-12.
9. Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: A review of the process. Am J Prev Med 2001;20(3 Suppl):21-35.
10. Andorsky RI, Goldner F. Colonic lavage solution (polyethylene glycol electrolyte lavage solution) as a treatment for chronic constipation: A double-blind, placebo-controlled study. Am J Gastroenterol 1990;85:261-65.
11. Attar A, Lemann M, Ferguson A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 1999;44:226-30.
12. Cleveland MV, Flavin DP, Ruben RA, et al. New polyethylene glycol laxative for treatment of constipation in adults: A randomized, double-blind, placebo-controlled study. South Med Assoc J 2001;94:478-81.
13. Corazziari E, Badiali D, Habib FI, et al. Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation. Dig Dis Sci 1996;41:1636-42.
14. Corazziari E, Badiali D, Bazzocchi G, et al. Long term efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation. Gut 2000;46:522-26.
15. DiPalma JA, DeRidder PH, Orlando RC, et al. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative [comment]. Am J Gastroenterol 2000;95:446-50.
16. Freedman MD, Schwartz HJ, Roby R, et al. Tolerance and efficacy of polyethylene glycol 3350/electrolyte solution versus lactulose in relieving opiate induced constipation: A double-blinded placebo-controlled trial. J Clin Pharmacol 1997;37:904-7.
17. Chaussade S, Minic M. Comparison of efficacy and safety of two doses of two different polyethylene glycol-based laxatives in the treatment of constipation. Aliment Pharmacol Ther 2003;17(1):165-72.
18. Christie AH, Culbert P, Guest JF. Economic impact of low dose polyethylene glycol 3350 plus electrolytes compared with lactulose in the management of idiopathic constipation in the UK. Pharmacoeconomics 2002;20:49-60.
19. Bass P, Dennis S. The laxative effects of lactulose in normal and constipated subjects. J Clin Gastroenterol 1981;3:23-28.
20. Sanders JF. Lactulose syrup assessed in a double-blind study of elderly constipated patients. J Am Geriatr Soc 1978;26:236-39.
21. Wesselius-De Casparis A, Braadbaart S, Bergh-Bohlken GE, et al. Treatment of chronic constipation with lactulose syrup: Results of a double-blind study. Gut 1968;9:84-86.
22. Kinnunen O, Winblad I, Koistinen P, et al. Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients. Pharmacology 1993;47:253-55.
23. Lederle FA, Busch DL, Mattox KM, et al. Cost-effective treatment of constipation in the elderly: A randomized double-blind comparison of sorbitol and lactulose. Am J Med 1990;89:597-601.
24. Passmore AP, Wilson-Davies K, Stoker C, et al. Chronic constipation in long stay elderly patients: A comparison of lactulose and a senna-fibre combination [comment]. Br Med J 1993;307:769-71.
25. Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 1993;47:249-52.
26. Rouse M, Chapman N, Mahapatra M, et al. An open, randomised, parallel group study of lactulose versus ispaghula in the treatment of chronic constipation in adults. Br J Clin Pract 1991;45:28-30.
27. Brocklehurst JC, Kirkland JL, Martin J, et al. Constipation in long-stay elderly patients: Its treatment and prevention by lactulose, poloxalkol-dihydroxyanthroquinolone and phosphate enemas. Gerontology 1983;29:181-84.
28. Kinnunen O, Salokannel J. Constipation in elderly long-stay patients: Its treatment by magnesium hydroxide and bulk-laxative. Ann Clin Res 1987;19:321-23.
29. MacLennan WJ, Pooler A. A comparison of sodium picosulphate ("Laxoberal") with standardised senna ("Senokot") in geriatric patients. Curr Med Res Opin 1974;2:641-47.
30. Marlett JA, Li BU, Patrow CJ, et al. Comparative laxation of psyllium with and without senna in an ambulatory constipated population. Am J Gastroenterol 1987;82:333-37.
31. Connolly P, Hughes IW, Ryan G. Comparison of "Duphalac" and "irritant" laxatives during and after treatment of chronic constipation: A preliminary study. Curr Med Res Opin 1974;2:620-5.
32. Rider JA. Treatment of acute and chronic constipation with bisoxatin acetate and bisacodyl. Double-blind crossover study. Curr Ther Res Clin Exp 1971;13:386-92.
33. Mundow L. Danthron/poloxalkol and placebo in puerperal constipation. Br J Clin Pract 1975;29:95-96.
34. Williamson J, Coll M, Connolly M. A comparative trial of a new laxative. Nurs Times 1975;71:1705-7.
35. Griffenberg L, Morris M, Atkinson N, et al. The effect of dietary fiber on bowel function following radical hysterectomy: A randomized trial. Gynecol Oncol 1997;66:417-24.
36. Hamilton JW, Wagner J, Burdick BB, et al. Clinical evaluation of methylcellulose as a bulk laxative. Dig Dis Sci 1988;33:993-918.
37. Anderson AS, Whichelow MJ. Constipation during pregnancy: Dietary fibre intake and the effect of fibre supplementation. Hum Nutr Appl Nutr 1985;39:202-7.
38. Badiali D, Corazziari E, Habib FI, et al. Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. Dig Dis Sci 1995;40:349-56.
39. Graham DY, Moser SE, Estes MK. The effect of bran on bowel function in constipation. Am J Gastroenterol 1982;77:599-603.
40. McCallum G, Ballinger BR, Presly AS. A trial of bran and bran biscuits for constipation in mentally handicapped and psychogeriatric patients. J Hum Nutr 1978;32:369-72.
41. Mantle J. Research and serendipitous secondary findings. Can Nurs 1992;88:15-18.
42. Finlay M. The use of dietary fibre in a long-stay geriatric ward. J Nutr Elder 1988;8:19-30.
43. Cheskin LJ, Kamal N, Crowell MD, et al. Mechanisms of constipation in older persons and effects of fiber compared with placebo. J Am Geriatr Soc 1995;43:666-69.
44. Ashraf W, Park F, Lof J, et al. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther 1995;9:639-47.
45. McRorie JW, Daggy BP, Morel JG, et al. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther 1998;12:491-917.
46. Dettmar PW, Sykes J. A multi-centre, general practice comparison of ispaghula husk with lactulose and other laxatives in the treatment of simple constipation. Curr Med Res Opin 1998;14:227-33.
47. Odes HS, Madar Z. A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation. Digestion 1991;49:65-71.
48. Fenn GC, Wilkinson PD, Lee CE, et al. A general practice study of the efficacy of Regulan in functional constipation. Br J Clin Pract 1986;40:192-97.
49. Pers M, Pers B. A crossover comparative study with two bulk laxatives. J Int Med Res 1983;11:51-53.
50. Mamtani R, Cimino JA, Kugel R, et al. A calcium salt of an insoluble synthetic bulking laxative in elderly bedridden nursing home residents. J Am Coll Nutr 1989;8:554-6.
51. Muller-Lissner SA. Treatment of chronic constipation with cisapride and placebo. Gut 1987;28:1033-38.
52. Muller-Lissner SA. Cisapride in chronic idiopathic constipation: Can the colon be re-educated? Bavarian Constipation Study Group. Eur J Gastroenterol Hepatol 1995;7:69-73.
53. Verheyen KVM, Demyttenaere P, Va Mierlo FJ. Double-blind comparison of two cisapride dosage regimens with placebo in the treatment of functional constipation. Curr Ther Res 1987;41:978-85.
54. Graham JR. Cisapride for severe non-ulcer dyspepsia, pseudoobstruction and constipation. Med J Aust 1989;150:667.
55. Jost WH, Schimrigk K. Cisapride treatment of constipation in Parkinson's disease. Mov Disord 1993;8:339-43.
56. Jost WH, Schimrigk K. Long-term results with cisapride in Parkinson's disease. Mov Disord 1997;12:423-25.
57. Longo WE, Woolsey RM, Vernava AM, et al. Cisapride for constipation in spinal cord injured patients: A preliminary report. J Spinal Cord Med 1995;18:240-44.
58. Wang SJ, Lan JL, Chen DY, et al. Effects of cisapride on colonic transit in patients with progressive systemic sclerosis. Clin Rheumatol 2002;21:271-74.
59. Frame PS, Dolan P, Kohli R, et al. Use of colchicine to treat severe constipation in developmentally disabled patients. J Am Board Fam Pract 1998;11:341-46.
60. Verne GN, Eaker EY, Davis RH, et al. Colchicine is an effective treatment for patients with chronic constipation: An open-label trial. Dig Dis Sci 1997;42:1959-63.
61. Verne GN, Davis RH, Robinson ME, et al. Treatment of chronic constipation with colchicine: Randomized, double-blind, placebo-controlled, crossover trial. Am J Gastroenterol 2003;98:1112-6.
62. Sandyk R, Gillman MA. Colchicine ameliorates constipation in Parkinson's disease. J R Soc Med 1984;77:1066.
63. Rajapakse R, Warman J, Korelitz BI. Colchicine for persistent constipation after total abdominal colectomy with ileorectostomy for colonic inertia. J Clin Gastroenterol 2001;33:81-84.
64. Soffer EE, Metcalf A, Launspach J. Misoprostol is effective treatment for patients with severe chronic constipation. Dig Dis Sci 1994;39:929-33.
65. Fain AM, Susat R, Herring M, et al. Treatment of constipation in geriatric and chronically ill patients: A comparison. South Med Assoc J 1978;71:677-80.
66. Castle SC, Cantrell M, Israel DS, et al. Constipation prevention: Empiric use of stool softeners questioned. Geriatrics 1991;46:84-86.
67. Hyland CM, Foran JD. Dioctyl sodium sulphosuccinate as a laxative in the elderly. Practitioner 1968;200:698-9.
68. Hurdon V, Viola R, Schroder C. How useful is docusate in patients at risk for constipation? A systematic review of the evidence in the chronically ill. J Pain Symptom Manage 2000;19:130-36.
69. Johanson JF, Wald A, Tougas G, et al. Effect of tegaserod in chronic constipation: A randomized, double-blind, controlled trial. Clin Gastroenterol Hepatol 2004;2:796-805.
70. Sharma SS, Bhargava N, Mathur SC. Effect of oral erythromycin on colonie transit in patients with idiopathic constipation. A pilot study. Dig Dis Sci 1995;40:2446-49.
71. Meier R, Beglinger C, Thimshirn M, et al. Therapeutic effects of loxiglumide, a cholecystokinin antagonist, on chronic constipation in elderly patients: A prospective, randomized, double-blind controlled trial. J Gastrointest Mot 1993;5:129-35.