Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido- methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: Synthesis and biological activities in vitro

Acta Pharmacologica Sinica

Volumn 30, Issue 9, 2009, Pages 1344-1350

  Zhang, Xu ^a   Zhou, Yang ^a   Shen, Yu ^a   Du, Li Li ^a   Chen, Jun Hua ^a   Leng, Ying ^a   Shen, Jian Hua ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

11 hydroxysteroid dehydrogenase type 1; Inhibitors; Molecular modeling

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; 2 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYL N METHYTHIAZOLE 4 CARBOXAMIDE; 2 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYL N PROPYLTHIAZOLE 4 CARBOXAMIDE; 2 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYLTHIAZOLE 4 CARBOXAMIDE; 2 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N,N DIETHYLTHIAZOLE 4 CARBOXAMIDE; 3 CHLORO N [[4 (2,6 DIMETHYLMORPHOLINE 4 CARBONYL)THIAZOL 2 YL]METHYL]BENZENESULFONAMIDE; 3 CHLORO N [[4 (PIPERIDINE 1 CARBONYL)THIAZOL 2 YL]METHYL]BENZENESULFONAMIDE; 3 CHLORO N [[4 (PYRROLIDINE 1 CARBONYL)THIAZOL 2 YL]METHYL]BENZENESULFONAMIDE; 3 CHLORO N [[5 (2,6 DIMETHYLMORPHOLINE 4 CARBONYL)PYRIDIN 2 YL]METHYL]BENZENESULFONAMIDE; 3 CHLORO N [[5 (PIPERIDINE 1 CARBONYL)PYRIDIN 2 YL]METHYL]BENZENESULFONAMIDE; 3 CHLORO N [[5 (PYRROLIDINE 1 CARBONYL)PYRIDIN 2 YL]METHYL]BENZENESULFONAMIDE; 6 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYL N METHYLNICOTINAMIDE; 6 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYL N PROPYLNICOTINAMIDE; 6 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYLNICOTINAMIDE; 6 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N,N DIETHYLNICOTINAMIDE; N BUTYL 2 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYLTHIAZOLE 4 CARBOXAMIDE; N BUTYL 6 [(3 CHLOROPHENYLSULFONAMIDO)METHYL] N CYCLOHEPTYLNICOTINAMIDE; NICOTINE DERIVATIVE; OXIDOREDUCTASE INHIBITOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BINDING SITES; BIOLOGICAL ASSAY; HUMANS; MICE; MICROSOMES; NICOTINE; SCINTILLATION COUNTING; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 70249130094     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.118     Document Type: Article

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