Plasticity of interstitial cells of cajal: A study in the small intestine of adult guinea pigs

Anatomical Record

Volumn 292, Issue 7, 2009, Pages 985-993

  Mei, Feng ^a   Han, Juan ^a   Huang, Yue ^a   Jiang, Zhong Yong ^a   Xiong, Cheng Jie ^a   Zhou, De Shan ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

smooth muscle actin; Imatinib; Interstitial cells of Cajal; Kit; SCF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; IMATINIB; STEM CELL FACTOR;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL MOTILITY DISORDER; GUINEA PIG; IMMUNOFLUORESCENCE; INTERSTITIAL CELL OF CAJAL; MALE; MYENTERIC PLEXUS; NICK END LABELING; NONHUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMALL INTESTINE;

ACTINS; ANIMALS; APOPTOSIS; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; ENTERIC NERVOUS SYSTEM; FEMALE; GUINEA PIGS; IN SITU NICK-END LABELING; INTESTINE, SMALL; MALE; MYOCYTES, SMOOTH MUSCLE; NEURONAL PLASTICITY; NEURONS; PHENOTYPE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES;

CAVIA; MAMMALIA;

EID: 70249123098     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20928     Document Type: Article

References (28)

1. Beckett EA, Ro S, Bayguinov Y, Sanders KM, Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236:60-72.
2. Bharucha AE, Philips SF. 2001. Slow-transit constipation. Curr Treat Opt Gastroenterol 4:309-315.
3. Ekblad E, Sjuve R, Arner A, Sundler F. 1998. Enteric neuronal plasticity and a reduced number of interstitial cells of Cajal in hypertrophic rat ileum. Gut 42:836-844.
4. Horvath VJ, Vittal H, Ordog T. 2005. Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach. Diabetes 54:1528-1533.
5. Horvath VJ, Vittal H, Lorincz A, Chen H, meida-Porada G, Redelman D, Ordog T. 2006. Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis. Gastroenterology 130:759-770.
6. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A. 1995. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373:347-349.
7. Kiyohara T, Shinomura Y, Isozaki K, Nakahara M, Tsutsui S, Nishibayashi H, Miyazaki Y, Miyagawa J, Matsuzawa Y. 2003. A decreased number of c-kit-expressing cells in a patient with afferent loop syndrome. J Gastroenterol 38:390-394.
8. Kluppel M, Huizinga JD, Malysz J, Bernstein A. 1998. Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn 211:60-71.
9. Komuro T, Zhou DS. 1996. Anti-c-kit protein immunoreactive cells corresponding to the interstitial cells of Cajal in the guinea-pig small intestine. J Auton Nerv Syst 61:169-174.
10. Lecoin L, Gabella G, Le Douarin N. 1996. Origin of the c-kit-positive interstitial cells in the avian bowel. Development 122:725-733.
11. Lorincz A, Redelman D, Horvath VJ, Bardsley MR, Chen H, Ordog T. 2008. Progenitors of interstitial cells of cajal in the postnatal murine stomach. Gastroenterology 134:1083-1093.
12. Maeda H, Yamagata A, Nishikawa S, Yoshinaga K, Kobayashi S, Nishi K, Nishikawa S. 1992. Requirement of c-kit for development of intestinal pacemaker system. Development 116:369-375.
13. Manley PW, Cowan-Jacob SW, Buchdunger E, Fabbro D, Fendrich G, Furet P, Meyer T, Zimmermann J. 2002. Imatinib: a selective tyrosine kinase inhibitor. Eur J Cancer 38 (Suppl 5):S19-S27.
14. Mei F, Yu B, Ma H, Zhang HJ, Zhou DS. 2006. Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs. Virchows Arch 449:348-357.
15. Mei F, Zhu J, Guo S, Zhou DS, Han J, Yu B, Li SF, Jiang ZY, Xiong CJ. 2009. An age-dependent proliferation is involved in the post-natal development of interstitial cells of Cajal in the small intestine of mice. Histochem Cell Biol 131:43-53.
16. Nakahara M, Isozaki K, Vanderwinden JM, Shinomura Y, Kitamura Y, Hirota S, Matsuzawa Y. 2002. Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factor. Life Sci 70:2367-2376.
17. Nakama A, Hirota S, Okazaki T, Nagano K, Kawano S, Hori M, Kitamura Y. 1998. Disturbed pyloric motility in Ws/Ws mutant rats due to deficiency of c-kit-expressing interstitial cells of Cajal. Pathol Int 48:843-849.
18. Popescu LM, Vidulescu C, Curici A, Caravia L, Simionescu AA, Ciontea SM, Simion S. 2006. Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine. Eur J Pharmacol 546:177-181.
19. Porcher C, Baldo M, Henry M, Orsoni P, Jule Y, Ward SM. 2002. Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease. Am J Gastroenterol 97:118-125.
20. Sanders KM, Ward SM. 2007. Kit mutants and gastrointestinal physiology. J Physiol 578:33-42.
21. Shimojima N, Nakaki T, Morikawa Y, Hoshino K, Kitajima M. 2005. Imatinib blocks spontaneous mechanical activities in the adult mouse small intestine: possible inhibition of c-Kit signaling. Pharmacology 74:95-99.
22. Torihashi S, Ward SM, Nishikawa S, Nishi K, Kobayashi S, Sanders KM. 1995. c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 280:97-111.
23. Torihashi S, Ward SM, Sanders KM. 1997. Development of c-Kit-positive cells and the onset of electrical rhythmicity in murine small intestine. Gastroenterology 112:144-155.
24. Torihashi S, Nishi K, Tokutomi Y, Nishi T, Ward S, Sanders KM. 1999. Blockade of kit signaling induces transdifferentiation of interstitial cells of cajal to a smooth muscle phenotype. Gastroenterology 117:140-148.
25. Ward SM, Burns AJ, Torihashi S, Sanders KM. 1994. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 480 (Part 1):91-97.
26. Ward SM, Burns AJ, Torihashi S, Harney SC, Sanders KM. 1995. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 269:C1577-C1585.
27. Ward SM, Brennan MF, Jackson VM, Sanders KM. 1999. Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle. J Physiol 516 (Part 3):835-846.
28. Ward SM, Sanders KM. 2001. Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol Gastrointest Liver Physiol 281:G602-G611.