Imatinib blocks spontaneous mechanical activities in the adult mouse small intestine: Possible inhibition of c-Kit signaling

Pharmacology

Volumn 74, Issue 2, 2005, Pages 95-99

  Shimojima, Naoki ^a   Nakaki, Toshio ^b   Morikawa, Yasuhide ^a   Hoshino, Ken ^a   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

Gastrointestinal motility; Interstitial cells of cajal; Pacemaker; Rhythmicity; Tyrosine kinase

Indexed keywords

IMATINIB; POTASSIUM ION;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GASTROINTESTINAL MOTILITY; INHIBITION KINETICS; INTESTINE CONTRACTION; INTESTINE MUSCLE; MALE; MOUSE; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; SMALL INTESTINE;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTESTINE, SMALL; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; SIGNAL TRANSDUCTION;

EID: 20444459855     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084021     Document Type: Article

References (22)

1. Torihashi S, Fujimoto T, Trost C, Nakayama S: Calcium oscillation linked to pacemaking of interstitial cells of Cajal: Requirement of calcium influx and localization of TRP4 in caveolae. J Biol Chem 2002;277:19191-19197.
2. 2+ signals in interstitial cells of Cajal and longitudinal smooth muscle cells during rhythmic activity in mouse ileum. J Physiol 2002;538:823-835.
3. Ward SM, Ordog T, Koh SD, Baker SA, Jun JY, Amberg G, Monaghan K, Sanders KM: Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria. J Physiol 2000;525:355-361.
4. Nakayama S, Torihashi S: Spontaneous rhythmicity in cultured cell clusters isolated from mouse small intestine. Jpn J Physiol 2002;52:217-227.
5. Torihashi S, Nishi K, Tokutomi Y, Nishi T, Ward S, Sanders KM: Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype. Gastroenterology 1999;117:140-148.
6. Ward SM, Harney SC, Bayguinov JR, McLaren GJ, Sanders KM: Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis. J Physiol 1997;505:241-258.
7. Ward SM, Burns AJ, Torihashi S, Sanders KM: Mutation of the proto-oncogene c-Kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 1994;480:91-97.
8. Torihashi S, Ward SM, Nishikawa S, Nishi K, Kobayashi S, Sanders KM: c-Kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 1995;280:97-111.
9. Maeda H, Yamagata A, Nishikawa S, Yoshinaga K, Kobayashi S, Nishi K: Requirement of c-kit for development of intestinal pacemaker system. Development 1992;116:369-375.
10. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A: W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995;373:347-349.
11. Fujita A, Okishio Y, Takeuchi T, Hata F: Roles of interstitial cells of Cajal in regulation of motility of the mouse intestine. Folia Pharmacol Jpn 2004;123:170-178.
12. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD: Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001;344:1052-1056.
13. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-480.
14. Manley PW, Cowan-Jacob SW, Buchdunger E, Fabbro D, Fendrich G, Furet P, Meyer T, Zimmermann J: Imatinib: a selective tyrosine kinase inhibitor. Eur J Cancer 2002;38(suppl 5):S19-S27.
15. Nakaki T, Otsuka Y, Nakayama M, Kato R: Endothelium-accelerated hyporesponsiveness of norepinephrine-elicited contraction of rat aorta in the presence of bacterial lipopolysaccharide. Eur J Pharmacol 1992;219:311-318.
16. Hennig GW, Hirst GD, Park KJ, Smith CB, Sanders KM, Ward SM, Smith TK: Propagation of pacemaker activity in the guinea-pig antrum. J Physiol 2004;556:585-599.
17. Postorino A, Mancinelli R, Racanicchi C, Adamo EB, Marini R: Spontaneous electromechanical activity in the rat duodenum in vitro. Arch Int Physiol Biochim 1990;98:35-40.
18. Buchdunger E, O'Reilly T, Wood J: Pharmacology of imatinib (STI571). Eur J Cancer 2002;38(suppl 5):S28-S36.
19. Nakamura E, Kito Y, Fukuta H, Yanai Y, Hashitani H, Yamamoto Y, Suzuki H: Cellular mechanism of the generation of spontaneous activity in gastric muscle. Folia Pharmacol Jpn 2004;123:141-148.
20. Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003;21:4342-4349.
21. Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ: Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000;96:925-932.
22. Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD: STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications. Oncogene 2001;20:5054-5058.