Double E1B 19kDa- and E1B 55kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect

Gene Therapy

Volumn 16, Issue 9, 2009, Pages 1111-1121

  Kim, J ^a   Kim, P H ^a   Yoo, J Y ^a   Yoon, A R ^a   Choi, H J ^a,b   Seong, J ^b   Kim, I W ^a   Kim, J H ^a,b   Yun, C O ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYTOCHROME C; E1B PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; ONCOLYTIC VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INDUCTION; VIRAL GENE DELIVERY SYSTEM; ADENOVIRUS; ANIMAL; BAGG ALBINO MOUSE; DRUG SCREENING; EVALUATION; FEMALE; GENETICS; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NUDE MOUSE; ONCOLYTIC VIROTHERAPY; PATHOLOGY; UTERINE CERVIX TUMOR;

ADENOVIRIDAE;

ADENOVIRIDAE; ADENOVIRUS E1B PROTEINS; ANIMALS; APOPTOSIS; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70249121760     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.72     Document Type: Article

References (37)

1. O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A et al. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004; 6: 611-623.
2. Dilley J, Reddy S, Ko D, Nguyen N, Rojas G, Working P et al. Oncolytic adenovirus CG7870 in combination with radiation demonstrates synergistic enhancements of antitumor efficacy without loss of specificity. Cancer Gene Ther 2005; 12: 715-722.
3. Idema S, Lamfers ML, van Beusechem VW, Noske DP, Heukelom S, Moeniralm S et al. AdDelta24 and the p53-expressing variant AdDelta24-p53 achieve potent antitumor activity in glioma when combined with radiotherapy. J Gene Med 2007; 9: 1046-1056.
4. Freytag SO, Barton KN, Brown SL, Narra V, Zhang Y, Tyson D et al. Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer. Mol Ther 2007; 15: 1600-1606.
5. Geoerger B, Grill J, Opolon P, Morizet J, Aubert G, Lecluse Y et al Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts. Br J Cancer 2003; 89: 577-584.
6. Rogulski KR, Freytag SO, Zhang K, Gilbert JD, Paielli DL, Kim JH et al. In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy. Cancer Res 2000; 60 1193-1196.
7. Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M et al. ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab 2003; 88: 5027-5032.
8. Freytag SO, Rogulski KR, Paielli DL, Gilbert JD, Kim JH. A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy. Hum Gene Ther 1998; 9: 1323-1333.
9. Yu DC, Chen Y, Dilley J, Li Y, Embry M, Zhang H et al. Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel. Cancer Res 2001; 61: 517-525.
10. Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J et al. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res 2002; 62: 5736-5742.
11. Chen Y, DeWeese T, Dilley J, Zhang Y, Li Y, Ramesh N et al. CV706, a prostate cancer-specific adenovirus variant, in combination with radiotherapy produces synergistic antitumor efficacy without increasing toxicity. Cancer Res 2001; 61: 5453-5460.
12. Freytag SO, Stricker H, Pegg J, Paielli D, Pradhan DG, Peabody J et al. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res 2003; 63: 7497-7506.
13. Boyd JM, Malstorm S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B et al. Adenovirus E1B 19kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 1994; 79: 341-351.
14. Chiou SK, Tseng CC, Rao L, White E. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J Virol 1994; 68: 6553-6566.
15. Huang DC, Cory S, Strasser A. Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene 1997; 14: 405-414.
16. Yoon AR, Kim JH, Lee YS, Kim H, Yoo JY, Sohn JH et al. Markedly enhanced cytolysis by E1B-19kD-deleted oncolytic adenovirus in combination with cisplatin. Hum Gene Ther 2006; 17: 379-390.
17. Kim J, Cho JY, Kim JH, Jung KC, Yun CO. Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy. Cancer Gene Ther 2002; 9: 725-736.
18. Belikova NA, Jiang J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J et al. Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys 2007; 69: 176-186.
19. Billis W, Fuks Z, Kolesnick R. Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells. Recent Prog Horm Res 1998; 53: 85-92; discussion 93.
20. Vladimirov Iu A, Klebanov GI, Borisenko GG, Osipov AN. [Molecular and cellular mechanisms of the low intensity laser radiation effect]. Biofizika 2004; 49: 339-350.
21. Mason KA, Neal R, Hunter N, Ariga H, Ang K, Milas L. CpG oligodeoxynucleotides are potent enhancers of radio- and chemoresponses of murine tumors. Radiother Oncol 2006; 80: 192-198.
22. Milas L, Fujii T, Hunter N, Elshaikh M, Mason K, Plunkett W et al. Enhancement of tumor radioresponse in vivo by gemcitabine. Cancer Res 1999; 59: 107-114.
23. Li Y, Yu DC, Chen Y, Amin P, Zhang H, Nguyen N et al. A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin. Cancer Res 2001; 61: 6428-6436.
24. Portella G, Scala S, Vitagliano D, Vecchio G, Fusco A. ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines. J Clin Endocrinol Metab 2002; 87 2525-2531.
25. Khuri FR, Nemunaitis J, Ganly I, Arseneau J, Tannock IF, Romel L et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 2000; 6: 879-885.
26. Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis. Oncogene 2003; 22: 5897-5906.
27. Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002; 2: 103-112.
28. Yun CO, Kim E, Koo T, Kim H, Lee YS, Kim JH. ADPoverexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis. Cancer Gene Ther 2005; 12: 61-71.
29. Kim JH, Lee YS, Kim H, Huang JH, Yoon AR, Yun CO. Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy. J Natl Cancer Inst 2006; 98: 1482-1493.
30. Chu RL, Post DE, Khuri FR, Van Meir EG. Use of replicating oncolytic adenoviruses in combination therapy for cancer. Clin Cancer Res 2004; 10: 5299-5312.
31. Kim J, Kim JH, Choi KJ, Kim PH, Yun CO. E1A- and E1B-double mutant replicating adenovirus elicits enhanced oncolytic and antitumor effects. Hum Gene Ther 2007; 18: 773-786.
32. Zhang M, Li S, Li J, Ensminger WD, Lawrence TS. Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts. Mol Ther 2003; 8: 21-28.
33. Qian J, Yang J, Dragovic AF, Abu-Isa E, Lawrence TS, Zhang M. Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2. Cancer Res 2005; 65: 5493-5497.
34. Simons JW, Marshall FF. The future of gene therapy in the treatment of urologic malignancies. Urol Clin North Am 1998; 25: 23-38.
35. Jereczek-Fossa BA, Marsiglia HR, Orecchia R. Radiotherapyrelated fatigue. Crit Rev Oncol Hematol 2002; 41: 317-325.
36. Jereczek-Fossa BA, Marsiglia HR, Orecchia R. Radiotherapy-related fatigue: How to assess and how to treat the symptom. A commentary. Tumori 2001; 87: 147-151.
37. Post DE, Khuri FR, Simons JW, Van Meir EG. Replicative oncolytic adenoviruses in multimodal cancer regimens. Hum Gene Ther 2003; 14: 933-946.