Anticonvulsant effects of the selective melatonin receptor agonist ramelteon

Epilepsy and Behavior

Volumn 16, Issue 1, 2009, Pages 52-57

  Fenoglio Simeone, Kristina ^a   Mazarati, Andrey ^b   Sefidvash Hockley, Sepideh ^c   Shin, Don ^b   Wilke, Julianne ^c   Milligan, Heather ^c   Sankar, Raman ^b   Rho, Jong M ^c   Maganti, Rama ^c  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Circadian rhythms; Epilepsy; Melatonin; Melatonin receptor; Ramelteon

Indexed keywords

MELATONIN RECEPTOR; POTASSIUM CHANNEL KV1.1; RAMELTEON;

ACTIMETRY; AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG TARGETING; ELECTROENCEPHALOGRAPHY; EPILEPSY; HIPPOCAMPUS; KINDLING; MALE; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PERIODICITY; PHYSICAL ACTIVITY; RAT; RECEPTOR UPREGULATION; REST; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALS; ANTICONVULSANTS; CIRCADIAN RHYTHM; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; INDENES; KINDLING, NEUROLOGIC; KV1.1 POTASSIUM CHANNEL; MALE; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; RATS; RATS, WISTAR; RECEPTORS, MELATONIN; SEIZURES;

EID: 70249113320     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.07.022     Document Type: Article

References (26)

1. Kwan P., and Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 342 (2000) 314-319
2. Dubocovih M.L. Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med 8 Suppl. 3 (2007) 34-42
3. Solmaz I, Gürkanlar D, Gökçil Z, Göksoy C, Ozkan M, Erdoǧan E. Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures. Neurol Res 2009 [Epub ahead of print].
4. Mevissen M., and Ebert U. Anticonvulsant effects of melatonin in amygdale-kindled rats. Neurosci Lett 257 (1998) 13-16
5. Tahsili-Fahadan P., Yahyavi-Firouz-Abadi N., Riazi K., Ghahremani M.H., and Dehpour A.R. Effect of acute and chronic photo-period modulation on pentylenetetrazol-induced clonic seizure threshold in mice. Epilepsy Res 82 (2008) 64-69
6. Janjoppi L., Silva de Lacerda A.F., Scorza F.A., Amado D., Cavalheiro E.A., and Arida R.M. Influence of pinealectomy on the amygdale kindling development in rats. Neurosci Lett 392 (2006) 150-153
7. Lothman E.W., Hatlelid J.M., Zorumski C.F., Conry J.A., Moon P.F., and Perlin J.B. Kindling with rapidly recurring hippocampal seizures. Brain Res 360 (1985) 83-91
8. Lothman E.W., and Williamson J.M. Rapid kindling with recurrent hippocampal seizures. Epilepsy Res 14 (1993) 209-220
9. Mazarati A., Shin D., Auvin S., and Sankar R. Age-dependent effects of topiramate on the acquisition and the retention of rapid kindling. Epilepsia 48 (2007) 765-773
10. Mazarati A., Wu J., Shin D., Kwon Y.S., and Sankar R. Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study. Epilepsia 49 (2008) 1777-1786
11. Mazarati A, Shin D, Sankar R. Bumetanide inhibits rapid kindling in neonatal rats. Epilepsia 2009 [Epub ahead of print]. doi: 10.1111/j.1528-1167.2009.02048.x.
12. Smart S.L., Lopantsev V., Zhang C.L., et al. Deletion of Kv1.1 potassium channel causes epilepsy in mice. Neuron 20 (1998) 809-819
13. Zuberi S.M., Eunson L.H., Spauschus A., et al. A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associated with episodic ataxia type-1 and sometimes with partial epilepsy. Brain 122 (1999) 817-825
14. Rho J.M., Szot P., Tempel B.L., and Schwartzkroin P.A. Developmental seizure susceptibility of kv1.1 potassium channel knock out mice. Dev Neurosci 21 (1999) 320-327
15. Fenoglio-Simeone KA, Wilke JC, Milligan HL, Allen CN, Rho JM, Maganti RM. Ketogenic diet treatment abolishes seizure periodicity and improves diurnal rhythmicity in epileptic Knca1-null mice. Epilepsia 2009 [Epub ahead of print]. doi: 10.1111/j.1528-1167.2009.02163.x.
16. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32 (1972) 281-294
17. Cavalheiro E.A., Naffah-Mazzacoratti M.G., Mello L.E., and Leite J.P. The pilocarpine model of seizures. In: Pitkanen A., Schwartzkroin P.A., and Moshe S.L. (Eds). Models of seizures and epilepsy (2006), Elsevier, Amsterdam 433-448
18. McIntyre D.C. The rapid kindling model of seizures. In: Pitkanen A., Schwartzkroin P.A., and Moshe S.L. (Eds). Models of seizures and epilepsy (2006), Elsevier, Amsterdam 352-364
19. Mazarati A., Shin D., Rogawski M., and Sankar R. Modification of rapid kindling epileptogenesis by ganaxolone and bumetanide [abstract]. Epilepsia 49 Suppl. 7 (2008) 369
20. De Smedt T., Vonck K., Raedt R., et al. Rapid kindling in preclinical antiepileptic drug development: the effect of levetiracetam. Epilepsy Res 67 (2005) 109-116
21. Morgan P.J., Barrett P., Howell H.E., and Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int 24 (1994) 101-146
22. Musshoff U., Riewenherm D., Berger E., Fauteck J.D., and Speckmann E.J. Melatonin receptors in rat hippocampus: molecular and functional investigations. Hippocampus 12 (2002) 165-173
23. Ray M., Mediratta P.K., Reeta Kh., Mahajan P., and Sharma K.K. Receptors mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. Methods Find Exp Clin Pharmacol 26 (2004) 177-181
24. Karim A., Tolbert D., and Cao C. Disposition kinetics and tolerance of escalating single doses of ramelteon, a high affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia. J Clin Pharmacol 46 (2006) 140-148
25. Miyamoto M., Nishikawa H., Doken Y., Hirai K., Uchikawa O., and Ohkawa S. The sleep promoting action of ramelteon (TAK-375) in freely moving cats. Sleep 27 (2004) 1319-1325
26. Yukuhiro N., Kimura H., Nishikawa H., Ohkawa S., Yoshikubo S., and Miyamoto M. Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. Brain Res 1027 (2004) 59-66